Asherman syndrome
disease diseaseOn this page
Also known as Asherman's Syndromeintrauterine adhesionsintrauterine synechiaeuterine synechiae
Summary
Asherman syndrome (MONDO:0015299) is a disease and 43 clinical trials. Top therapeutic interventions include estradiol valerate, hyaluronic acid, and dydrogesterone. A subtype of female reproductive system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: 1-5 / 10 000 (Europe) [Orphanet-validated]
- Phenotypes (HPO): 11
- Clinical trials: 43
Clinical features
Epidemiology
Prevalence records
1 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 44 | Europe | Validated |
Signs & symptoms
Clinical features (HPO)
11 HPO clinical features (Orphanet curated; top 11 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0000140 | Abnormality of the menstrual cycle | Frequent (30-79%) |
| HP:0000868 | Decreased fertility in females | Frequent (30-79%) |
| HP:0000876 | Oligomenorrhea | Frequent (30-79%) |
| HP:0000789 | Infertility | Occasional (5-29%) |
| HP:0000869 | Secondary amenorrhea | Occasional (5-29%) |
| HP:0002574 | Episodic abdominal pain | Occasional (5-29%) |
| HP:0005268 | Spontaneous abortion | Occasional (5-29%) |
| HP:0100607 | Dysmenorrhea | Occasional (5-29%) |
| HP:0100608 | Metrorrhagia | Occasional (5-29%) |
| HP:0031035 | Chronic infection | Very rare (<1-4%) |
| HP:0100767 | Abnormality of the placenta | Very rare (<1-4%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | Asherman syndrome |
| Mondo ID | MONDO:0015299 |
| Orphanet | 137686 |
| ICD-10-CM | N85.6 |
| ICD-11 | 2022431339 |
| SNOMED CT | 48236007 |
| UMLS | C0156372 |
| MedGen | 57629 |
| GARD | 0005853 |
| MedDRA | 10022821, 10053868 |
| NORD | 811 |
| Is cancer (heuristic) | no |
Also known as: Asherman syndrome · Asherman’s Syndrome · Asherman’s syndrome · intrauterine adhesions · intrauterine synechiae · uterine synechiae
Disease family
This is a subtype of female reproductive system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › Asherman syndrome
Related subtypes (33): ectopic pregnancy, pelvic inflammatory disease, endosalpingiosis, vaginal disorder, prolapse of female genital organ, Allen-Masters syndrome, fallopian tube disorder, vulvar disease, uterine disorder, gynatresia, Bartholin duct cyst, ovarian disorder, hymen, imperforate, preterm premature rupture of the membranes, mammary-digital-nail syndrome, uterine cervical aplasia and agenesis, longitudinal vaginal septum, transverse vaginal septum, polycystic ovaries-urethral sphincter dysfunction syndrome, granulomatous mastitis, vaginal atresia, mullerian aplasia, vulvovaginal gingival syndrome, isolated partial vaginal agenesis, female infertility, female reproductive system neoplasm, polyp of vulva, vulval varices, vulvodynia, menstrual cycle-dependent periodic fever, Bartholin’s gland disease, delayed puberty, self-limited, menstrual disorder
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 43.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 28 |
| PHASE4 | 5 |
| PHASE1/PHASE2 | 4 |
| PHASE2 | 3 |
| PHASE1 | 2 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04671914 | PHASE4 | RECRUITING | Prevalence of Intrauterine Adhesions After D&C With or Without Antiadhesion Gel After Abortion in Second Trimester. |
| NCT01632202 | PHASE4 | TERMINATED | Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy |
| NCT02144987 | PHASE4 | COMPLETED | Bone Marrow Stem Cell Treatment for Asherman’s Syndrome and Endometrial Atrophy |
| NCT02204358 | PHASE4 | UNKNOWN | Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells |
| NCT03620929 | PHASE4 | UNKNOWN | Estrogen in the Prevention of Adhesion Reformation |
| NCT06896747 | PHASE1/PHASE2 | RECRUITING | Evaluating Mechanically Engineered Stem Cell Exosomes for Treating Endometrial Injury: A Clinical Study |
| NCT07034963 | PHASE1/PHASE2 | ACTIVE_NOT_RECRUITING | Study on the Effective Dose and Safety of Esketamine in Hysteroscopic Surgery Under Monitored Anesthesia Care |
| NCT02726971 | PHASE1/PHASE2 | COMPLETED | Comparison of Different Doses of Oestrogen Therapy for Preventing Intrauterine Adhesion |
| NCT02825849 | PHASE2 | TERMINATED | Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair |
| NCT03166189 | PHASE2 | COMPLETED | Autologous Bone Marrow-derived Mesenchymal Stem Cells for Atrophic Endometrium in Patients With Repeated IVF Failures |
| NCT04432467 | PHASE1/PHASE2 | COMPLETED | Fertility Restoration Using Autologous Mesenchymal Stem Cells |
| NCT05095597 | PHASE2 | COMPLETED | Umbilical Cord Plasma for Treating Endometrial Pathologies (Thin Endometrium / Asherman’s Syndrome/ Endometria Atrophy) |
| NCT07230600 | PHASE1 | RECRUITING | AD-SVF Therapy for Refractory Endometrial Infertility |
| NCT03223454 | PHASE1 | UNKNOWN | Human Amniotic Epithelial Cells for Asherman’s Syndrome |
| NCT05343572 | EARLY_PHASE1 | RECRUITING | Bone Marrow Derived Stem Cells Mobilization for Treatment of Abnormal Endometrium |
| NCT04963179 | Not specified | ACTIVE_NOT_RECRUITING | PREvention of Intrauterine Adhesion After Adhesiolysis With Novel Tri-block deGradable Polymer Film. |
| NCT06450301 | Not specified | RECRUITING | Senescent Endometrial Cells in Patients with Thin Endometrial Lining |
| NCT06608407 | Not specified | ENROLLING_BY_INVITATION | Platelet Rich Plasma in the Prevention of Adhesion Reformation |
| NCT07074795 | Not specified | ACTIVE_NOT_RECRUITING | Use of Nitrous Oxide During Office Hysteroscopy |
| NCT07160764 | Not specified | NOT_YET_RECRUITING | Safety and Performance of the Semical Adhesion Barrier Gel for Prevention of Intra-uterine Adhesion |
| NCT07176143 | Not specified | NOT_YET_RECRUITING | hBMSC Uterine Artery Infusion for Severe IUA-Related Infertility |
| NCT07416578 | Not specified | ACTIVE_NOT_RECRUITING | Clinical Study on the Effect of Umbilical Cord Mesenchymal Stem Cell Exosomes on Endometrial Repair of Intrauterine Adhesions |
| NCT07536971 | Not specified | NOT_YET_RECRUITING | Clinical Study of i-PRF Intrauterine Perfusion for Endometrial Regeneration and Repair in Moderate to Severe Intrauterine Adhesions |
| NCT07611474 | Not specified | RECRUITING | To Evaluate the Safety and Effectiveness of Intrauterine Adhesion Preventer in the Prevention and Treatment of Intrauterine Adhesions, a Prospective, Multicenter, Randomized Controlled Clinical Trial |
| NCT01377779 | Not specified | COMPLETED | Efficiency of Intercoat (Oxiplex/AP Gel)in Decreasing Intrauterine Adhesions |
| NCT01637974 | Not specified | UNKNOWN | Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery |
| NCT02132104 | Not specified | UNKNOWN | Efficiency of Amnion Graft to Prevent Intrauterine Adhesions After Hysteroscopic Surgery |
| NCT02313415 | Not specified | COMPLETED | Treatment of Infertility by Collagen Scaffold Loaded With Umbilical Cord Derived Mesenchyma Stem Cells |
| NCT02404454 | Not specified | UNKNOWN | Prevention of Intrauterine Adhesions After Hysteroscopic Metroplasty With Autocross-linked Hyaluronic Acid Gel |
| NCT02496052 | Not specified | UNKNOWN | The Efficacy and Safety of the Dried Biological Amnion Graft in Patients With Intrauterine Adhesions |
| NCT02680366 | Not specified | COMPLETED | Treatment of Severe Asherman Syndrome by Collagen Scaffold Loaded With Autologous Bone Marrow Mononuclear Cells |
| NCT02708277 | Not specified | COMPLETED | Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Severe Intrauterine Adhesions |
| NCT02744807 | Not specified | COMPLETED | Role of Chronic Endometritis in Postoperative Recurrence of Severe Intrauterine Adhesions |
| NCT02746679 | Not specified | COMPLETED | Impact of Mindfulness Based Stress Reduction on Anxiety, Depression and QOL in Women With Intrauterine Adhesion. |
| NCT02867202 | Not specified | COMPLETED | Adjuvant Therapy for Intrauterine Adhesions Between Two Groups |
| NCT03249415 | Not specified | COMPLETED | Use of PRP in Endometrial Reconstruction |
| NCT03665649 | Not specified | UNKNOWN | Pre-clinical Endometrial Tissular Renovation Study |
| NCT03731689 | Not specified | UNKNOWN | Treatment of Intrauterine Adhesions and Its Distribution of Genital Tract Flora |
| NCT04424160 | Not specified | COMPLETED | Effects of Platelet Rich Plasma on Endometrium |
| NCT04638855 | Not specified | COMPLETED | The Efficacy and Safety of Medicurtain® in Patients With Hysteroscopy (Pivotal Study) |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ESTRADIOL VALERATE | 4 | 2 |
| HYALURONIC ACID | 4 | 2 |
| DYDROGESTERONE | 4 | 1 |