Astroviridae infectious disease

Summary

Astroviridae infectious disease (MONDO:0005658) is a disease with 2 GWAS associations across 1 studies. A subtype of primary viral infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• GWAS associations: 2

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	Astroviridae infectious disease
Mondo ID	MONDO:0005658
MeSH	D019350
UMLS	C0376550
MedGen	84000
Is cancer (heuristic)	no

Data availability: 2 GWAS associations (1 study).

Disease family

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › viral infectious disease › primary viral infectious disease › Astroviridae infectious disease

Related subtypes (31): plantar wart, monkeypox, smallpox, rubella, human papilloma virus infection, Rotavirus infection, Arenaviridae infectious disease, Caliciviridae infectious disease, cowpox, Flaviviridae infectious disease, Hepadnaviridae infectious disease, Herpesviridae infectious disease, influenza, Mononegavirales infectious disease, Nidovirales infectious disease, phlebotomus fever, Picornaviridae infectious disease, polyomavirus infectious disease, Togaviridae infectious disease, viral encephalitis, viral hepatitis, viral pneumonia, viral exanthem, deltaretrovirus infections, Bunyaviridae infectious disease, viral sexually transmitted disease, lentivirus infection, viral myocarditis, viral pericarditis, adenoviridae infectious disease, aleutian mink disease, human

Genetics & variants

GWAS landscape

2 GWAS associations across 1 studies. Top hits map to 1 distinct genes (as reported by GWAS).

Top associations by p-value

rsID	p-value	Gene	Risk allele	Odds ratio
rs75437404	9e-09	RPLP0P4 - LORICRIN	?	2.71
rs75935441	1e-08	PRLHR	?	4.17

Top studies (by case count)

Study	Lead author	Year	Cases	Controls	Title
GCST90446496	Chen L	2024	177	0	Genetic Susceptibility to Astrovirus Diarrhea in Bangladeshi Infants.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

Tier	Variants
Tier 1: coding	0
Tier 2: splice/UTR	1
Tier 3: regulatory	0
Tier 4: intronic/intergenic	1

MAF distribution

Bucket	Variants
common (>=0.05)	2
low_freq (0.01-0.05)	0
rare (<0.01)	0
unknown	0

Functional consequences

Consequence	Count
intergenic_variant	1
3_prime_UTR_variant	1

Top variants

rsID	Chr	Pos	Alleles	MAF	Consequence	Gene	p-value	Tier
rs75437404	1	153244341	T>A,C,G	0.05	intergenic_variant	RPLP0P4 - LORICRIN	9e-09	Tier 4: intronic/intergenic
rs75935441	10	118590592	T>A,C	0.05	3_prime_UTR_variant	PRLHR	1e-08	Tier 2: splice/UTR

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.