Autoimmune pancreatitis
disease diseaseOn this page
Also known as AIPlymphoplasmocytic sclerosing pancreatitis
Summary
Autoimmune pancreatitis (MONDO:0015175) is a disease and 19 clinical trials. Top therapeutic interventions include rituximab. A subtype of autoimmune disorder of endocrine system — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 19
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | autoimmune pancreatitis |
| Mondo ID | MONDO:0015175 |
| MeSH | D000081012 |
| Orphanet | 103919 |
| DOID | DOID:0040091 |
| ICD-11 | 2057951941 |
| SNOMED CT | 448542008 |
| UMLS | C2609129 |
| MedGen | 750633 |
| GARD | 0010911 |
| MedDRA | 10069002 |
| Is cancer (heuristic) | no |
Also known as: AIP · lymphoplasmocytic sclerosing pancreatitis
Disease family
This is a subtype of autoimmune disorder of endocrine system. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › endocrine system disorder › autoimmune disorder of endocrine system › autoimmune pancreatitis
Related subtypes (12): type 1 diabetes mellitus, autoimmune thyroid disease, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, autoimmune hepatitis, autoimmune polyendocrinopathy, autoimmune hypoparathyroidism, insulin autoimmune syndrome, IgG4-related sclerosing cholangitis, lymphocytic hypophysitis, autoimmune oophoritis, autoimmune primary ovarian failure
Subtypes (2): autoimmune pancreatitis type 1, autoimmune pancreatitis type 2
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 19.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 16 |
| PHASE1/PHASE2 | 1 |
| PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01584388 | PHASE1/PHASE2 | COMPLETED | Rituximab in IgG4-RD: A Phase 1-2 Trial |
| NCT02766842 | PHASE2 | WITHDRAWN | Evaluation of a New EUS Guided Biopsy Needle (SharkCore) Comparing to Standard EUS Needle (ProCore) |
| NCT02705638 | PHASE1 | COMPLETED | Treatment of IgG4-Related Disease With Revlimid and Rituximab |
| NCT06753318 | Not specified | NOT_YET_RECRUITING | Validation of Joint-AI in Diagnosing Pancreatic Solid Lesions |
| NCT07536841 | Not specified | RECRUITING | Validation of the Odesa Criteria 2026 for Autoimmune Pancreatitis |
| NCT00588367 | Not specified | COMPLETED | CT Pancreas Perfusion |
| NCT01774513 | Not specified | UNKNOWN | EUS-guided Procore-biopsy in Diagnosing Autoimmune Pancreatitis |
| NCT01845467 | Not specified | WITHDRAWN | Efficacy of Secretin MRCP in the Diagnosis and Follow up of Auto Immune Pancreatitis |
| NCT02797665 | Not specified | UNKNOWN | Treatment of Obstructive Jaundice in Autoimmune Pancreatitis and/or Immunoglobulin G4-related Sclerosing Cholangitis by Corticosteroids |
| NCT03241797 | Not specified | COMPLETED | Evaluation of EUS-guided FNA for Diagnosing Autoimmune Pancreatitis |
| NCT03753815 | Not specified | UNKNOWN | Diagnostic Yield of FNA Needle and FNB Needle for Autoimmune Pancreatitis |
| NCT04397731 | Not specified | COMPLETED | Prospective Study on the Role of Eus-fnb in the Diagnosis of Autoimmune Pancreatitis |
| NCT04834505 | Not specified | COMPLETED | To Differentiate Focal Autoimmune Pancreatitis From Pancreatic Cancer by Endoscopic Ultrasound |
| NCT05171517 | Not specified | COMPLETED | Study on Microflora Characteristics of Pancreatic Solid Lesions Via Endoscopic Ultrasound-guided Fine Needle Aspiration/Biopsy |
| NCT05476978 | Not specified | COMPLETED | Artificial Intelligence in EUS for Diagnosing Pancreatic Solid Lesions |
| NCT05565066 | Not specified | COMPLETED | A Real-world Comparison of FNB and FNA in IHC-required Lesions. |
| NCT06358001 | Not specified | COMPLETED | EchoTip AcuCore Post-Market Clinical Study |
| NCT06369909 | Not specified | UNKNOWN | Study on AI-assisted Multimodal Diagnosis System of Autoimmune Pancreatitis |
| NCT06699667 | Not specified | COMPLETED | CT Findings in Surgically Treated Focal Pancreatic Disease- A Retrospective Study |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| RITUXIMAB | 4 | 2 |
Related Atlas pages
- Drugs: Rituximab