◎ Sugi Atlas

Atlas / Disease / Autonomic neuropathy

Autonomic neuropathy

disease
On this page

Also known as autonomic nervous system peripheral neuropathyautonomic peripheral neuropathyperipheral neuropathy of autonomic nervous system

Summary

Autonomic neuropathy (MONDO:0001300) is a disease and 16 clinical trials. Top therapeutic interventions include iobenguane and isoxaflutole. A subtype of autonomic nervous system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Clinical trials: 16

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical nameautonomic neuropathy
Mondo IDMONDO:0001300
DOIDDOID:0060054, DOID:11504
NCITC27033
SNOMED CT277879009
UMLSC0259749
MedGen82621
Anatomy (UBERON)UBERON:0002410
Is cancer (heuristic)no

Also known as: autonomic nervous system peripheral neuropathy · autonomic peripheral neuropathy · peripheral neuropathy of autonomic nervous system

Disease family

This is a subtype of autonomic nervous system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › autonomic nervous system disorder › autonomic neuropathy

Related subtypes (12): idiopathic peripheral autonomic neuropathy, autonomic nervous system neoplasm, Frey syndrome, harlequin syndrome, chronic hiccup, pure autonomic failure, baroreflex failure, autonomic dysreflexia, dysautonomia, sympathetic nervous system disorder, parasympathetic nervous system disorder, central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease

Subtypes (2): Horner syndrome, diabetic autonomic neuropathy

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 16.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified16

Top trials by phase / activity

NCTPhaseStatusTitle
NCT04310644Not specifiedRECRUITINGAutonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry
NCT00466778Not specifiedCOMPLETEDAutonomic Nervous System Dysfunction and Peripheral Neuropathy in a Cohort of Asymptomatic Juvenile Diabetic Patients (Type I): A Case-Controlled Study
NCT00866801Not specifiedCOMPLETEDCoronary Blood Flow Regulation During General Anesthesia
NCT01160887Not specifiedCOMPLETEDDiabetes Peripheral Neuropathy and Small-fibre Nerve Damage: A Comparative Study
NCT01822431Not specifiedUNKNOWNA Comparison Between Pupillometry, Heart Rate Variability and Metaiodobenzylguanidine Scintigraphy for the Diagnosis of Early Diabetic Autonomic Neuropathy in Type 1 Diabetes
NCT02608424Not specifiedCOMPLETEDEffects of Feet Mechanical Stimulation on Cardiovascular Autonomic Profile and Inflammation in Parkinson’s Disease
NCT02633891Not specifiedCOMPLETEDMetabolic Syndrome and Fall Risk
NCT02715713Not specifiedWITHDRAWNAutonomic Manifestations of Testosterone Deficiency in Men
NCT03094910Not specifiedCOMPLETEDInvestigation of the Rewarming og the Fingers After Cooling and the Autonomic Nervous System in Raynaud’s Phenomenon
NCT03660618Not specifiedTERMINATEDLSFG-SKIN, Laser Speckle Flowgraphy
NCT04208295Not specifiedUNKNOWN24-hour Blood Pressure Dynamics and Autonomic Adrenergic Regulation in Type 2 Diabetics
NCT05043636Not specifiedUNKNOWNDiabetic Neuropathy Screening Study 1.1 + Substudy 1.2-1.3-1.4
NCT05200676Not specifiedCOMPLETEDCardiac Arrhythmias in Greenland
NCT05299918Not specifiedCOMPLETEDDiabetic Neuropathy Rapid Screening Test in Turkish Patients With Type 2 Diabetes: Sudoscan
NCT05315739Not specifiedCOMPLETEDVagus Nerve Stimulation for Systemic Lupus Erythematous
NCT05993871Not specifiedCOMPLETEDDiabetic Small Fiber Neuropathy: Clinical, Electrophysiological and Neurosonographic Study

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
IOBENGUANE42
ISOXAFLUTOLE21

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 21

This page pulls from 21 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogenccgwasgwas_studyhgncmedgenmeshmimmondomondochildmondoparentncitorphanetsctiduberonumls