Autosomal recessive omodysplasia

Summary

Autosomal recessive omodysplasia (MONDO:0009779) is a disease caused by GPC6 (GenCC Strong), with 2 cohort genes.

At a glance

• Prevalence: <1 / 1 000 000 (Worldwide) [Orphanet-validated]
• Causal gene: GPC6 (GenCC Strong)
• Cohort genes: 2
• ClinVar variants: 132
• Phenotypes (HPO): 24

Clinical features

Epidemiology

Prevalence records

2 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Cases/families		23	Worldwide	Validated
Point prevalence	<1 / 1 000 000		Worldwide	Validated

Signs & symptoms

Clinical features (HPO)

24 HPO clinical features (Orphanet curated; top 24 by frequency):

HPO ID	Term	Frequency
HP:0000343	Long philtrum	Very frequent (80-99%)
HP:0000358	Posteriorly rotated ears	Very frequent (80-99%)
HP:0000369	Low-set ears	Very frequent (80-99%)
HP:0000463	Anteverted nares	Very frequent (80-99%)
HP:0000944	Abnormal metaphysis morphology	Very frequent (80-99%)
HP:0002007	Frontal bossing	Very frequent (80-99%)
HP:0002818	Abnormal morphology of the radius	Very frequent (80-99%)
HP:0003042	Elbow dislocation	Very frequent (80-99%)
HP:0004322	Short stature	Very frequent (80-99%)
HP:0005025	Hypoplastic distal humeri	Very frequent (80-99%)
HP:0005280	Depressed nasal bridge	Very frequent (80-99%)
HP:0008905	Rhizomelia	Very frequent (80-99%)
HP:0000028	Cryptorchidism	Frequent (30-79%)
HP:0000347	Micrognathia	Frequent (30-79%)
HP:0002823	Abnormality of femur morphology	Frequent (30-79%)
HP:0002983	Micromelia	Frequent (30-79%)
HP:0003027	Mesomelia	Frequent (30-79%)
HP:0001059	Pterygium	Occasional (5-29%)
HP:0001249	Intellectual disability	Occasional (5-29%)
HP:0001363	Craniosynostosis	Occasional (5-29%)
HP:0003196	Short nose	Occasional (5-29%)
HP:0010880	Increased nuchal translucency	Occasional (5-29%)
HP:0030680	Abnormal cardiovascular system morphology	Occasional (5-29%)
HP:0100790	Hernia	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	autosomal recessive omodysplasia
Mondo ID	MONDO:0009779
OMIM	258315
Orphanet	93329
DOID	DOID:0080844
ICD-11	350802889
SNOMED CT	725166005
UMLS	C1850318
MedGen	340513
GARD	0004076
Is cancer (heuristic)	no

Also known as: autosomal recessive omodysplasia · micromelic dysplasia congenita with dislocation of radius · micromelic dysplasia-dislocation of radius syndrome · OMOD1 · omodysplasia 1 · omodysplasia autosomal recessive · omodysplasia generalised form · omodysplasia generalized form · omodysplasia type 1 · omodysplasia, autosomal recessive · omodysplasia, generalised form

Data availability: 132 ClinVar variants · 5 GenCC gene-disease records.

Disease family

Classification path: disease › human disease › disease by etiologic mechanism › disease of genetic or genomic mechanism › hereditary disease › autosomal genetic disease › autosomal recessive disease › autosomal recessive omodysplasia

Related subtypes (218): immunodeficiency-centromeric instability-facial anomalies syndrome, hypercalcemia, infantile, Ochoa syndrome, autosomal recessive Ehlers-Danlos syndrome, vascular type, hydrolethalus syndrome, 3-M syndrome, isolated hyperchlorhidrosis, dacryocystitis-osteopoikilosis syndrome, Hutchinson-Gilford progeria syndrome, achalasia microcephaly syndrome, acrorenal syndrome, autosomal recessive, beta-ketothiolase deficiency, autosomal recessive Alport syndrome, Alstrom syndrome, microphthalmia with limb anomalies, camptodactyly-arthropathy-coxa vara-pericarditis syndrome, Behr syndrome, bifid nose, autosomal recessive, Bloom syndrome, Bowen-Conradi syndrome, camptodactyly with fibrous tissue hyperplasia and skeletal dysplasia, heart defects-limb shortening syndrome, autosomal recessive palmoplantar keratoderma and congenital alopecia, COFS syndrome, craniometaphyseal dysplasia, autosomal recessive, Fraser syndrome, cystic fibrosis, polycystic lipomembranous osteodysplasia with sclerosing leukoencephaly, persistent hyperplastic primary vitreous, autosomal recessive, Donnai-Barrow syndrome, Schöpf-Schulz-Passarge syndrome, cleft lip/palate-ectodermal dysplasia syndrome, Ellis-van Creveld syndrome, Wolcott-Rallison syndrome, autosomal recessive faciodigitogenital syndrome, acromesomelic dysplasia 2B, brittle cornea syndrome, triple-A syndrome, autosomal recessive humeroradial synostosis, multinucleated neurons-anhydramnios-renal dysplasia-cerebellar hypoplasia-hydranencephaly syndrome, hydrocephalus, nonsyndromic, autosomal recessive 1, autosomal recessive hydrocephalus due to congenital stenosis of aqueduct of Sylvius, hypertelorism, microtia, facial clefting syndrome, hypoparathyroidism-retardation-dysmorphism syndrome, Vici syndrome, Johanson-Blizzard syndrome, autosomal recessive Kenny-Caffey syndrome, Papillon-Lefevre disease, Haim-Munk syndrome, Laurence-Moon syndrome, Donohue syndrome, lipase deficiency, combined, autosomal recessive familial Mediterranean fever, thiamine-responsive megaloblastic anemia syndrome, cartilage-hair hypoplasia, Nijmegen breakage syndrome, pseudo-TORCH syndrome, Galloway-Mowat syndrome, mulibrey nanism, myotonia congenita, autosomal recessive, Schwartz-Jampel syndrome, proteosome-associated autoinflammatory syndrome, Netherton syndrome, Niemann-Pick disease type A, oculodentodigital dysplasia, autosomal recessive, odonto-onycho-dermal dysplasia, osteoporosis-pseudoglioma syndrome, Shwachman-Diamond syndrome, phenylketonuria, Bjornstad syndrome, Laron syndrome, autosomal recessive polycystic kidney disease, autosomal recessive inherited pseudoxanthoma elasticum, autosomal recessive multiple pterygium syndrome, rapadilino syndrome, short-rib thoracic dysplasia 9 with or without polydactyly, autosomal recessive Robinow syndrome, Sjogren-Larsson syndrome, scapuloperoneal spinal muscular atrophy, autosomal recessive, spondyloepiphyseal dysplasia tarda, autosomal recessive, inherited threoninemia, Pendred syndrome, autosomal recessive spondylocostal dysostosis, Werner syndrome, ABCD syndrome, Naxos disease, autosomal recessive amelia, human HOXA1 syndromes, sickle cell disease, autosomal recessive proximal renal tubular acidosis, hyper-IgM syndrome type 2, temtamy preaxial brachydactyly syndrome, TH-deficient dopa-responsive dystonia, craniosynostosis syndrome, autosomal recessive, Niemann-Pick disease type B, skin fragility-woolly hair-palmoplantar keratoderma syndrome, CoQ-responsive OXPHOS deficiency, familial adenomatous polyposis 2, Pierson syndrome, palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome, cardiomyopathy-hypotonia-lactic acidosis syndrome, PHARC syndrome, Kahrizi syndrome, cutis laxa with severe pulmonary, gastrointestinal and urinary anomalies, congenital prothrombin deficiency, immunodeficiency 31B, dyskeratosis congenita, autosomal recessive 2, dyskeratosis congenita, autosomal recessive 3, Nestor-Guillermo progeria syndrome, leukoencephalopathy with calcifications and cysts, mitochondrial pyruvate carrier deficiency, branched-chain keto acid dehydrogenase kinase deficiency, dyskeratosis congenita, autosomal recessive 5, hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome, alacrima, achalasia, and intellectual disability syndrome, hyperlipoproteinemia, type 1D, microcephaly and chorioretinopathy 2, congenital stationary night blindness 1G, combined oxidative phosphorylation deficiency 29, hypermanganesemia with dystonia 2, growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy, gnb5-related intellectual disability-cardiac arrhythmia syndrome, autosomal recessive spastic paraplegia type 78, autosomal recessive limb-girdle muscular dystrophy, Bardet-Biedl syndrome, autosomal recessive cerebellar ataxia, neuronopathy, distal hereditary motor, autosomal recessive, UV-sensitive syndrome, Ehlers-Danlos syndrome, kyphoscoliotic type 1, Cockayne syndrome, hyperphenylalaninemia due to tetrahydrobiopterin deficiency, leukoencephalopathy-palmoplantar keratoderma syndrome, autosomal recessive hypohidrotic ectodermal dysplasia, Warburg micro syndrome, autosomal recessive primary microcephaly, autosomal recessive progressive external ophthalmoplegia, Meier-Gorlin syndrome, autosomal recessive sideroblastic anemia, autosomal recessive intermediate Charcot-Marie-Tooth disease, Perrault syndrome, autosomal recessive hypophosphatemic rickets, de Barsy syndrome, leukocyte adhesion deficiency, Senior-Loken syndrome, autosomal recessive spastic ataxia, childhood-onset autosomal recessive myopathy with external ophthalmoplegia, autosomal recessive cerebral atrophy, GM3 synthase deficiency, autosomal recessive distal renal tubular acidosis, pigmentation defects-palmoplantar keratoderma-skin carcinoma syndrome, autosomal recessive brachyolmia, Aicardi-Goutieres syndrome, homocystinuria without methylmalonic aciduria, Niemann-Pick disease type C, nephronophthisis, autosomal recessive osteopetrosis, peroxisome biogenesis disorder, congenital non-bullous ichthyosiform erythroderma, Seckel syndrome, Usher syndrome, autosomal recessive cutis laxa type 1, autosomal recessive cutis laxa type 2, hearing loss, autosomal recessive, microcephaly, growth restriction, and increased sister chromatid exchange 2, encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1, congenital vertebral-cardiac-renal anomalies syndrome, hair defect with photosensitivity and intellectual disability syndrome, autosomal recessive severe congenital neutropenia, severe combined immunodeficiency due to CARMIL2 deficiency, extraoral halitosis due to methanethiol oxidase deficiency, neurodevelopmental disorder with microcephaly, impaired language, epilepsy, and gait abnormalities, mitochondrial complex 2 deficiency, nuclear type 3, mitochondrial complex 2 deficiency, nuclear type 4, mismatch repair cancer syndrome, spondyloepimetaphyseal dysplasia with joint laxity, type 3, Kilquist syndrome, Duane anomaly-myopathy-scoliosis syndrome, autosomal recessive axonal charcot-marie-tooth disease due to copper metabolism defect, immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections-lymphopenia syndrome, optic atrophy-ataxia-peripheral neuropathy-global developmental delay syndrome, congenital myopathy with reduced type 2 muscle fibers, NAD(P)HX dehydratase deficiency, autosomal recessive ocular albinism, ichthyosis linearis circumflexa, eosinophil peroxidase deficiency, hyperphenylalaninemia due to DNAJC12 deficiency, autosomal recessive epidermolytic ichthyosis, Ehlers-Danlos syndrome, classic-like, 2, joint laxity, short stature, and myopia, HELIX syndrome, auditory neuropathy-optic atrophy syndrome, glycosylphosphatidylinositol biosynthesis defect 15, neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures, SCN4A-related myopathy, autosomal recessive, Uner Tan Syndrome, nephropathic cystinosis, Imerslund-Grasbeck syndrome type 1, Imerslund-Grasbeck syndrome type 2, permanent neonatal diabetes mellitus 1, growth hormone insensitivity with immune dysregulation 1, autosomal recessive, Rajab interstitial lung disease with brain calcifications 1, Roberts-SC phocomelia syndrome, neurodevelopmental disorder with microcephaly, impaired language, and gait abnormalities, RPE65-related recessive retinopathy, GUCY2D-related recessive retinopathy, autosomal recessive titinopathy, intellectual disability, autosomal recessive, ALPL-related autosomal recessive hypophosphatasia, spastic paraplegia 18b, autosomal recessive, CEP164-related ciliopathy, RP1-related recessive retinopathy, pseudohypoaldosteronism, type IB2, autosomal recessive, pseudohypoaldosteronism, type IB3, autosomal recessive, spastic paraplegia 30B, autosomal recessive, cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1, brain small vessel disease 2B, autosomal recessive, IMPG1-related recessive retinopathy, PROM1-related recessive retinopathy

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

ClinVar germline variants

132 retrieved; paginated sample, class counts are floors:

85 uncertain significance, 29 benign, 7 pathogenic, 5 likely benign, 4 conflicting classifications of pathogenicity, 2 benign/likely benign

ClinVar	Variant (HGVS)	Gene	Classification	Review
5549	NM_005708.5(GPC6):c.778del (p.Leu260fs)	GPC6	Pathogenic	no assertion criteria provided
5550	NC_000013.11:g.93997007_94063501del66495insATAAATCACTTAGAGATGT	GPC6	Pathogenic	no assertion criteria provided
5551	NC_000013.11:g.94252984_94352299del99316insCTA	GPC6	Pathogenic	no assertion criteria provided
5553	NM_005708.3(GPC6):c.712_877dup	GPC6	Pathogenic	no assertion criteria provided
5552	NM_005708.5(GPC6):c.700C>T (p.Arg234Ter)	GPC6-AS2	Pathogenic	no assertion criteria provided
5554	NM_005708.3(GPC6):c.320_711del	GPC6-AS2	Pathogenic	no assertion criteria provided
5555	NM_005708.3(GPC6):c.320_711del	GPC6-AS2	Pathogenic	no assertion criteria provided
312551	NM_005708.5(GPC6):c.1485A>T (p.Ser495=)	GPC6	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications
312553	NM_005708.5(GPC6):c.1524G>A (p.Thr508=)	GPC6	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications
881581	NM_005708.5(GPC6):c.1289+13C>T	GPC6	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications
882731	NM_005708.5(GPC6):c.1512C>T (p.Asp504=)	GPC6	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications
1806178	NM_005708.5(GPC6):c.1228G>A (p.Glu410Lys)	GPC6	Uncertain significance	criteria provided, single submitter
287156	NM_005708.5(GPC6):c.1129G>A (p.Ala377Thr)	GPC6	Uncertain significance	criteria provided, multiple submitters, no conflicts
3065600	NM_005708.5(GPC6):c.49C>T (p.Leu17Phe)	GPC6	Uncertain significance	criteria provided, single submitter
3065690	NM_005708.5(GPC6):c.1193T>G (p.Val398Gly)	GPC6	Uncertain significance	criteria provided, single submitter
312530	NM_005708.5(GPC6):c.-442C>T	GPC6	Uncertain significance	criteria provided, single submitter
312532	NM_005708.5(GPC6):c.-307T>A	GPC6	Uncertain significance	criteria provided, single submitter
312534	NM_005708.5(GPC6):c.-133G>T	GPC6	Uncertain significance	criteria provided, single submitter
312535	NM_005708.5(GPC6):c.-100G>A	GPC6	Uncertain significance	criteria provided, single submitter
312536	NM_005708.5(GPC6):c.-69C>T	GPC6	Uncertain significance	criteria provided, single submitter
312537	NM_005708.5(GPC6):c.-23G>T	GPC6	Uncertain significance	criteria provided, single submitter
312538	NM_005708.5(GPC6):c.49C>A (p.Leu17Ile)	GPC6	Uncertain significance	criteria provided, multiple submitters, no conflicts
312539	NM_005708.5(GPC6):c.161-4G>T	GPC6	Uncertain significance	criteria provided, single submitter
312540	NM_005708.5(GPC6):c.585C>T (p.Asp195=)	GPC6	Uncertain significance	criteria provided, single submitter
312542	NM_005708.5(GPC6):c.1033A>G (p.Lys345Glu)	GPC6	Uncertain significance	criteria provided, single submitter
312543	NM_005708.5(GPC6):c.1088G>A (p.Arg363His)	GPC6	Uncertain significance	criteria provided, multiple submitters, no conflicts
312544	NM_005708.5(GPC6):c.1137A>C (p.Thr379=)	GPC6	Uncertain significance	criteria provided, single submitter
312545	NM_005708.5(GPC6):c.1162A>G (p.Ile388Val)	GPC6	Uncertain significance	criteria provided, multiple submitters, no conflicts
312546	NM_005708.5(GPC6):c.1216A>G (p.Ile406Val)	GPC6	Uncertain significance	criteria provided, multiple submitters, no conflicts
312552	NM_005708.5(GPC6):c.1496G>A (p.Ser499Asn)	GPC6	Uncertain significance	criteria provided, multiple submitters, no conflicts

Genes & proteins

Mendelian disease overlap and somatic drivers

GenCC: 5 · Orphanet: 1 · OMIM-shared: 0 · Dual-evidence (GWAS+Mendelian): 0

GenCC gene–disease validity (cohort genes)

the Disease column is the GenCC-asserted condition — a cohort gene’s strongest validity may be for a related predisposition syndrome.

Gene	Classification	Inheritance	Disease	Records
GPC6	Strong	Autosomal recessive	autosomal recessive omodysplasia	5

Orphanet rare-disease linkage (cohort genes)

Gene	Orphanet ID	Rare disease
GPC6	Orphanet:93329	Autosomal recessive omodysplasia

Cohort genes → proteins

2 cohort genes, 1 distinct canonical proteins.

Evidence partition

Subset	Genes
multi_evidence	2

Cohort genes (full)

Symbol	HGNC	Ensembl	UniProt	Name	Evidence
GPC6	HGNC:4454	ENSG00000183098	Q9Y625	Glypican-6	gencc,clinvar
GPC6-AS2	HGNC:39910	ENSG00000224394		GPC6 antisense RNA 2	clinvar

Cohort function summary

Lead sentence per gene, UniProt-curated.

Symbol	Protein name	Function (lead sentence)
GPC6	Glypican-6	Cell surface proteoglycan that bears heparan sulfate.

Protein-family classification

Druggable: 0 · Difficult: 0 · Unknown: 2 · Druggable fraction: 0.0

Family distribution

Cohort families vs a genome-wide background (hypergeometric, BH-FDR; fold = observed/expected). Counts kept; sorted by enrichment, so the catch-all Other/Unknown bucket no longer leads.

Family	Genes	Fold	FDR
Other/Unknown	2	1.8×	0.312

Per-gene assignment

Symbol	Family	Druggable?	EC	InterPro (top 3)
GPC6	Other/Unknown	no		Glypican, Glypican_CS
GPC6-AS2	Other/Unknown	no

Expression context

Cohort genes with no expression data: 0.

1 cohort gene are a single-cell marker in ≥1 SCXA experiment.

Breadth distribution (Bgee present_calls)

Bucket	Genes
narrow (1-5 tissues)	0
moderate (6-20)	0
broad (>20)	2
unknown	0

Top tissues across cohort

Tissue	Cohort genes
cartilage tissue	1
tibia	1
vena cava	1
adrenal gland	1
adrenal tissue	1
male germ line stem cell (sensu Vertebrata) in testis	1

Per-gene tissue summary (top 30)

Symbol	Bgee breadth	FANTOM5 breadth	SCXA	Top tissues
GPC6	217	ubiquitous	marker	cartilage tissue, tibia, vena cava
GPC6-AS2	81		yes	male germ line stem cell (sensu Vertebrata) in testis, adrenal tissue, adrenal gland

Protein interactions among cohort

Intra-cohort edges: 0.

Hub genes (top 10 by interactor count)

Symbol	Interactor count
GPC6	1,237
GPC6-AS2	0

Structural data

PDB: 0 · AlphaFold-only: 1 · No structure: 1

AlphaFold-only cohort genes (top 30 by pLDDT)

Symbol	UniProt	pLDDT
GPC6	Q9Y625	82.67

Function

Pathway analysis

Distinct Reactome pathways touched by cohort: 16. Enrichment computed across 2 evidence-associated genes (1 with Reactome annotation).

Pathways by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 1 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

Pathway	Cohort genes	Fold	FDR	Sample cohort genes
Defective EXT2 causes exostoses 2	1	815.7×	0.004	GPC6
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	1	815.7×	0.004	GPC6
Attachment and Entry	1	601.0×	0.004	GPC6
Defective B4GALT7 causes EDS, progeroid type	1	571.0×	0.004	GPC6
Defective B3GAT3 causes JDSSDHD	1	571.0×	0.004	GPC6
Defective B3GALT6 causes EDSP2 and SEMDJL1	1	571.0×	0.004	GPC6
HS-GAG degradation	1	496.5×	0.004	GPC6
Respiratory syncytial virus (RSV) attachment and entry	1	496.5×	0.004	GPC6
Initiation of coagulation cascade	1	475.8×	0.004	GPC6
Glycosaminoglycan-protein linkage region biosynthesis	1	393.8×	0.004	GPC6
HS-GAG biosynthesis	1	346.1×	0.004	GPC6
Dengue Virus Attachment and Entry	1	259.6×	0.005	GPC6
Retinoid metabolism and transport	1	248.3×	0.005	GPC6
Regulation of clotting cascade	1	233.1×	0.005	GPC6
RSV-host interactions	1	156.4×	0.007	GPC6
Dengue Virus-Host Interactions	1	45.7×	0.022	GPC6

GO biological processes by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 1 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

GO term	Cohort genes	Fold	FDR	Sample cohort genes
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	1	887.0×	0.003	GPC6
regulation of signal transduction	1	267.5×	0.006	GPC6
cell migration	1	61.5×	0.016	GPC6

Therapeutics

Drug target analysis

Approved (phase 4): 0 · Phase ≥3: 0 · Phased (≥1): 0 · Undrugged: 2

Druggability breadth: 0 of 2 evidence-associated genes (0%) have a ChEMBL target (buckets above are over the deeply-mined display cohort).

Top cohort targets by molecule count

Symbol	Molecules	Max phase
GPC6	0	0
GPC6-AS2	0	0

Bioactivity and enzyme data

Enzyme cohort genes (≥1 EC): 0.

Pharmacogenomics

Cohort genes with a PharmGKB record: 1; with CPIC/DPWG dosing guidelines: 0.

No cohort gene has a CPIC/DPWG genotype-guided dosing guideline (PharmGKB).

Chemical tractability of cohort targets

0 approved/phased compounds have measured bioactivity against a cohort gene (and aren’t yet in disease-level trials). This is a research / tractability signal, NOT a therapeutic recommendation — a bioactivity row often reflects off-target or screening binding (e.g. promiscuous kinase inhibitors against a cohort kinase), implying no disease mechanism.

Druggability pyramid

Cohort genes binned by druggability tier (high → low):

Tier	Definition	Genes	Symbols
A	Approved (phase 4 drug)	0
B	Phased (≥1) drug, not yet approved	0
C	Druggable family + PDB, no drug	0
D	Druggable family + AlphaFold only, no drug	0
E	Difficult family or no structure, no drug	2	GPC6, GPC6-AS2

Undrugged target profiles

2 cohort genes are undrugged. Ranked by ‘starting-point quality’ (assay depth + drugged-partner adjacency).

Symbol	ChEMBL assays	Drugged partners (top 3)
GPC6	0	—
GPC6-AS2	0	—

Clinical trials & evidence

Clinical trials

Clinical trials: 0.