Avascular necrosis

Summary

Avascular necrosis (MONDO:0018373) is a disease and 139 clinical trials. Top therapeutic interventions include acetaminophen, celecoxib, and desflurane. A subtype of osteonecrosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 139

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	avascular necrosis
Mondo ID	MONDO:0018373
Orphanet	399164
NCIT	C34841
SNOMED CT	397758007
UMLS	C0027543
MedGen	10200
GARD	0021658
Is cancer (heuristic)	no

Also known as: avascular necrosis of bone · AVN

Disease family

This is a subtype of osteonecrosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › osteonecrosis › avascular necrosis

Related subtypes (6): Kummell disease, osteochondrosis, osteonecrosis of genetic origin, idiopathic phalangeal acro-osteolysis, Dieterich disease, osteoradionecrosis

Subtypes (3): dysbaric osteonecrosis, secondary avascular necrosis, primary avascular necrosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 139.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	109
PHASE4	21
PHASE3	4
PHASE2	3
PHASE1/PHASE2	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07240649	PHASE4	NOT_YET_RECRUITING	Outcomes From Hyperbaric Oxygen (HBO2) Treatment for Emerging Indications
NCT00208364	PHASE4	TERMINATED	A Two Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Metal-on-Metal Bearing in Primary Total Hip Replacement
NCT00208377	PHASE4	TERMINATED	A Multi-centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery
NCT00208390	PHASE4	TERMINATED	A Multi-centre Study to Assess the Long-term Performance of the Summit™ Hip in Primary Total Hip Replacement
NCT00208403	PHASE4	TERMINATED	A Randomised Single Centre Study to Compare the Long-term Performance of Acryloc™ and Palacos® R Bone Cements in Primary Total Hip Replacement
NCT00208429	PHASE4	WITHDRAWN	A Multi-centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Polyethylene-on-metal Bearing in Primary Total Hip Replacement
NCT00208442	PHASE4	COMPLETED	A Randomised Single Centre Study to Compare the Long-term Wear Characteristics of Marathon™ and Enduron™ Polyethylene Cup Liners in Primary Total Hip Replacement
NCT00208455	PHASE4	TERMINATED	A Multi-centre Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Replacement
NCT00546598	PHASE4	TERMINATED	Post-approval Study of the DURALOC® Option Ceramic-on-Ceramic Hip Prosthesis System
NCT00715026	PHASE4	TERMINATED	Trilogy AB Acetabular Hip System Post Approval Study
NCT00764673	PHASE4	COMPLETED	The 3DKnee™ System: A Post-Market Study
NCT00872066	PHASE4	COMPLETED	A Study to Assess the Long-term Performance of SmartSet® HV and SmartSet® GHV Bone Cements in Primary Total Hip Replacement
NCT00872222	PHASE4	TERMINATED	A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement
NCT00872547	PHASE4	TERMINATED	Multi-Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Resurfacing and Primary Total Hip Replacement
NCT00872573	PHASE4	TERMINATED	A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stem™ AMT in a Total Primary Hip Replacement
NCT00872794	PHASE4	TERMINATED	A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery
NCT00873444	PHASE4	TERMINATED	A Randomised Study to Compare Metal Ion Release and Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-Metal or a Metal-on-Metal Bearing
NCT01134445	PHASE4	TERMINATED	An Electronic Data Capture Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Replacement
NCT01422564	PHASE4	TERMINATED	Metal on Metal Versus Metal on Highly Crossed Linked Polyethylene Sytem
NCT01635166	PHASE4	TERMINATED	Multi-centre Study to Assess the Long-term Performance of the Deltamotion Cup System in Primary Hip Replacement Surgery
NCT03540030	PHASE4	COMPLETED	Opioid-Free Shoulder Arthroplasty
NCT03040778	PHASE3	ACTIVE_NOT_RECRUITING	Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ)
NCT00208351	PHASE3	TERMINATED	A Randomised Single Centre Study to Compare the Long-term Performance of 4 Designs of the DePuy Ultima LX Stem in Primary Total Hip Replacement
NCT00208468	PHASE3	TERMINATED	A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement
NCT00765362	PHASE3	COMPLETED	Mobile - Bearing Knee Study
NCT06016634	PHASE2	RECRUITING	Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
NCT00412841	PHASE2	TERMINATED	Atorvastatin to Prevent Avascular Necrosis of Bone in Steroid Treated Exacerbated Systemic Lupus Erythematosus
NCT02342977	PHASE2	WITHDRAWN	Effects of Lacosamide on Post-operative Opioid Requirements After a Total Hip Arthroplasty:
NCT02448121	PHASE1/PHASE2	UNKNOWN	Autologous Bone Marrow Stem Cell Transplantation for Osteonecrosis in Sickle Cell Disease
NCT01791738	PHASE1	COMPLETED	Acetabular Shell Positioning Using Patient Specific Instruments
NCT01107340	Not specified	ACTIVE_NOT_RECRUITING	AMIStem Primary Hip System Prospective Post-marketing Multi-centre Surveillance Study
NCT01307384	Not specified	ACTIVE_NOT_RECRUITING	Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study
NCT01480440	Not specified	ACTIVE_NOT_RECRUITING	Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
NCT01700543	Not specified	ACTIVE_NOT_RECRUITING	Sidus(TM) Post Market Clinical Follow-up (PMCF) Study
NCT02199600	Not specified	ACTIVE_NOT_RECRUITING	The Medacta International GMK Sphere Post-Marketing Surveillance Study
NCT03034811	Not specified	ACTIVE_NOT_RECRUITING	Persona Partial Knee Clinical Outcomes Study
NCT03048201	Not specified	RECRUITING	Physica System Total Knee Replacement Registry Study
NCT03266874	Not specified	ACTIVE_NOT_RECRUITING	G7 BiSpherical Acetabular Shell PMCF Study
NCT03312465	Not specified	ACTIVE_NOT_RECRUITING	Anatomical Shoulder Domelock System Study
NCT03343171	Not specified	ACTIVE_NOT_RECRUITING	Continuum Ceramic on Ceramic Bearing Post Market Clinical Follow-Up Study

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ACETAMINOPHEN	4	1
CELECOXIB	4	1
DESFLURANE	4	1
GABAPENTIN	4	1
KETOROLAC TROMETHAMINE	4	1
LACOSAMIDE	4	1
METHYCLOTHIAZIDE	4	1
OXYGEN	4	1
PENTOXIFYLLINE	4	1
ROCURONIUM	4	1
VECURONIUM	4	1
CHEMBL4067090	0	1
ALPHA-TOCOPHEROL	0	1
ALUMINIUM OXIDE	-1	1