axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy

Summary

axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy (MONDO:0016176) is a disease. A subtype of acquired peripheral neuropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 19

Clinical features

Signs & symptoms

Clinical features (HPO)

19 HPO clinical features (Orphanet curated; top 19 by frequency):

HPO ID	Term	Frequency
HP:0002166	Impaired vibration sensation in the lower limbs	Very frequent (80-99%)
HP:0007133	Progressive peripheral neuropathy	Very frequent (80-99%)
HP:0011402	Demyelinating sensory neuropathy	Very frequent (80-99%)
HP:0002936	Distal sensory impairment	Frequent (30-79%)
HP:0003693	Distal amyotrophy	Frequent (30-79%)
HP:0007002	Motor axonal neuropathy	Frequent (30-79%)
HP:0007220	Demyelinating motor neuropathy	Frequent (30-79%)
HP:0007267	Chronic axonal neuropathy	Frequent (30-79%)
HP:0007340	Lower limb muscle weakness	Frequent (30-79%)
HP:0100287	EMG: slow motor conduction	Frequent (30-79%)
HP:0005508	Monoclonal immunoglobulin M proteinemia	Occasional (5-29%)
HP:0003390	Sensory axonal neuropathy	Occasional (5-29%)
HP:0007240	Progressive gait ataxia	Occasional (5-29%)
HP:0012514	Lower limb pain	Occasional (5-29%)
HP:0031006	Acroparesthesia	Occasional (5-29%)
HP:0002665	Lymphoma	Very rare (<1-4%)
HP:0006775	Multiple myeloma	Very rare (<1-4%)
HP:0025346	Increased circulating beta-2-microglobulin level	Very rare (<1-4%)
HP:0100778	Cryoglobulinemia	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy
Mondo ID	MONDO:0016176
Orphanet	209004
UMLS	C6012217
MedGen	1876718
GARD	0020415
Is cancer (heuristic)	no

Disease family

Classification path: disease › human disease › disease by body system or component › nervous system disorder › peripheral nervous system disorder › peripheral neuropathy › acquired peripheral neuropathy › axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy

Related subtypes (11): cranial neuralgia, neuralgic amyotrophy, POEMS syndrome, non-recovering obstetric brachial plexus lesion, anterior cutaneous nerve entrapment syndrome, pudendal neuralgia, polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG, multifocal motor neuropathy, CANOMAD syndrome, simple cryoglobulinemia, radiation-induced plexopathy

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.