Basilar artery occlusion

Summary

Basilar artery occlusion (MONDO:0001715) is a disease and 24 clinical trials. Top therapeutic interventions include tenecteplase and minocycline. A subtype of occlusion precerebral artery — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 24

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	basilar artery occlusion
Mondo ID	MONDO:0001715
DOID	DOID:13446
SNOMED CT	195180004
UMLS	C0265098
MedGen	539076
Anatomy (UBERON)	UBERON:0001633
Is cancer (heuristic)	no

Disease family

This is a subtype of occlusion precerebral artery. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › brain disorder › cerebrovascular disorder › occlusion precerebral artery › basilar artery occlusion

Related subtypes (2): vertebral artery occlusion, carotid artery occlusion

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 24.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	17
PHASE4	2
PHASE3	2
PHASE2/PHASE3	1
PHASE2	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05512910	PHASE4	ACTIVE_NOT_RECRUITING	Minocycline for Acute Ischemic Stroke Undergoing Endovascular Treatment Due to Basilar Artery Occlusion (MIST-B)
NCT07203625	PHASE4	RECRUITING	Tenecteplase Before Interhospital Transfer in Acute Basilar Artery Occlusion at 4.5 to 24 Hours
NCT05105633	PHASE2/PHASE3	RECRUITING	Extending the Time Window for Tenecteplase by Recanalization of Basilar Artery Occlusion in Posterior Circulation Stroke
NCT05827042	PHASE3	RECRUITING	Endovascular Thrombectomy Alone Versus Intravenous Thrombolysis Plus Thrombectomy on Acute Basilar Artery Occlusion
NCT05701956	PHASE3	COMPLETED	Intravenous Tenecteplase Plus EVT Versus EVT Alone on 4.5 to 24 Hours After Basilar Artery Occlusion
NCT05580822	PHASE2	UNKNOWN	Additive Effects of Intra-arterial Tenecteplase for Successful Thrombectomy Due to Acute Basilar Artery Occlusion
NCT06489925	EARLY_PHASE1	NOT_YET_RECRUITING	Cerebrolysin as an Add-On Therapy to Standard Treatment of Basilar Artery Occlusion
NCT05320263	Not specified	RECRUITING	Contact Aspiration Versus Stent Retriever for Recanalisation of Acute Stroke Patients With Basilar Artery Occlusion: The Posterior Circulation ASTER Randomized Trial Protocol
NCT05615038	Not specified	ACTIVE_NOT_RECRUITING	A Comparison of Contact Aspiration Versus Stent Retriever for Acute Basilar Artery Occlusion
NCT06101667	Not specified	RECRUITING	Efficacy and Safety of Endovascular Recanalization for Acute Basilar Artery Occlusion With Extended Time Window (ANGEL-BAO)
NCT06560203	Not specified	RECRUITING	Basilar Artery Occlusion Chinese Endovascular Trial in the Extended Time Window
NCT06843356	Not specified	RECRUITING	Trial of Rescue Endovascular Treatment for Progressive Acute Mild Ischemic Stroke With Basilar Artery Occlusion With Extended Time Window
NCT06924996	Not specified	ENROLLING_BY_INVITATION	Efficacy and Safety of Endovascular Thrombectomy in Acute Ischemic Stroke With Posterior Circulation Large Infarct
NCT07046299	Not specified	NOT_YET_RECRUITING	Basilar Artery Occlusion Chinese Endovascular Trial in Patients With Large Core Infarct
NCT07090941	Not specified	RECRUITING	EVT in Acute Basilar Artery Occlusion With Large Infarction Core
NCT07333950	Not specified	NOT_YET_RECRUITING	The Efficacy and Safety of Endovascular Therapy for Acute Ischemic Stroke Due to Large Core Infarction
NCT07345702	Not specified	NOT_YET_RECRUITING	Basilar Artery Occlusion Chinese Endovascular Registry in Patients With Large-Core Infarct
NCT07390032	Not specified	NOT_YET_RECRUITING	The Efficacy and Safety of Endovascular Treatment for Acute Mild Basilar Artery Occlusion
NCT01717755	Not specified	UNKNOWN	Basilar Artery International Cooperation Study
NCT02737189	Not specified	COMPLETED	Basilar Artery Occlusion Chinese Endovascular Trial
NCT04177615	Not specified	UNKNOWN	Randomized Assessment of Rapid Endovascular Treatment in Basilar Artery Occlusion Stroke in 115 Hospital
NCT04751708	Not specified	COMPLETED	Endovascular Treatment for Acute Basilar Artery Occlusion
NCT05402878	Not specified	UNKNOWN	OUTCOME AND SAFETY OF RECANALIZATION TREATMENTS IN ISCHEMIC STROKE DUE TO ACUTE BASILAR ARTERY OCCLUSION
NCT05631847	Not specified	COMPLETED	Direct Endovascular Treatment Versus Bridging Treatment In Basilar Artery Occlusive Stroke

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
TENECTEPLASE	4	4
MINOCYCLINE	4	1