Benign laryngeal neoplasm

Summary

Benign laryngeal neoplasm (MONDO:0002354) is a cancer (an umbrella term covering 6 Mondo subtypes) and 4 clinical trials. A subtype of respiratory system benign neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 6 Mondo subtypes
• Clinical trials: 4

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	benign laryngeal neoplasm
Mondo ID	MONDO:0002354
DOID	DOID:2598
ICD-10-CM	D14.1
ICD-11	669823967
NCIT	C3601
SNOMED CT	92175003
UMLS	C0153952
MedGen	56325
Anatomy (UBERON)	UBERON:0001737
Is cancer (heuristic)	yes

Also known as: benign laryngeal neoplasm · benign laryngeal tumor · benign laryngeal tumour · benign larynx neoplasm · benign larynx tumor · benign larynx tumour · benign neoplasm of larynx · benign neoplasm of the larynx · benign tumor of larynx · benign tumor of the larynx · benign tumour of larynx · benign tumour of the larynx · laryngeal neoplasm, benign · laryngeal tumor · laryngeal tumour · larynx benign neoplasm · larynx neoplasm

Disease family

This is a subtype of respiratory system benign neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › respiratory system disorder › respiratory system benign neoplasm › benign laryngeal neoplasm

Related subtypes (14): endobronchial lipoma, lung benign neoplasm, paranasal sinus Schneiderian papilloma, benign neoplasm of pleura, benign neoplasm of hypopharynx, benign neoplasm of nasal cavity, benign neoplasm of sphenoidal sinus, benign neoplasm of nasopharynx, benign neoplasm of oropharynx, benign neoplasm of frontal sinus, benign neoplasm of maxillary sinus, benign neoplasm of tonsil, benign neoplasm of ethmoidal sinus, benign neoplasm of trachea

Subtypes (6): laryngeal leiomyoma, larynx squamous papilloma, benign neoplasm of epiglottis, benign neoplasm of glottis, benign neoplasm of subglottis, laryngeal papillomatosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 4.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	3
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00128817	PHASE3	TERMINATED	Concurrent Chemoradiation Versus Surgery With Adjuvant Therapy in Advanced Laryngopharyngeal Cancers
NCT03214835	Not specified	WITHDRAWN	CDx Biopsies for Detection of Laryngopharyngeal Reflux and Laryngeal Lesions
NCT03942380	Not specified	UNKNOWN	Cell-free Tumor DNA in Head and Neck Cancer Patients
NCT05346237	Not specified	COMPLETED	Validation and Cross-cultural Adaptation of Croatian SECEL Questionnaire