Benign neoplasm of brain

Summary

Benign neoplasm of brain (MONDO:0021451) is a cancer (an umbrella term covering 7 Mondo subtypes) and 9 clinical trials. Top therapeutic interventions include pioglitazone. A subtype of central nervous system organ benign neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 7 Mondo subtypes
• Clinical trials: 9

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	benign neoplasm of brain
Mondo ID	MONDO:0021451
EFO	EFO:1000107
NCIT	C4781
SNOMED CT	92030004
UMLS	C0496899
MedGen	99225
Anatomy (UBERON)	UBERON:0000955
Is cancer (heuristic)	yes

Also known as: benign brain neoplasm · benign brain tumor · benign brain tumour · benign neoplasm of the brain · benign tumor of brain · benign tumor of the brain · benign tumour of brain · benign tumour of the brain · brain benign neoplasm · brain neoplasms, benign

Disease family

This is a subtype of central nervous system organ benign neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › benign neoplasm › nervous system benign neoplasm › central nervous system organ benign neoplasm › benign neoplasm of brain

Related subtypes (12): central nervous system chondroma, central nervous system hemangioma, central nervous system leiomyoma, central nervous system lipoma, craniopharyngioma, benign neoplasm of spinal cord, benign neoplasm of meninges, benign neoplasm of peripheral nervous system, myxoid glioneuronal tumor, diffuse leptomeningeal glioneuronal tumor, multinodular and vacuolating neuronal tumor, polymorphous low grade neuroepithelial tumor of the young

Subtypes (7): intracranial hemangioma, pineocytoma, benign neoplasm of pituitary gland, benign neoplasm of cerebrum, benign neoplasm of cerebellum, benign neoplasm of brain stem, benign choroid plexus neoplasm

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 9.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE2	2
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01445691	PHASE2	WITHDRAWN	More Complete Removal of Malignant Brain Tumors by Fluorescence-Guided Surgery
NCT06322342	PHASE2	COMPLETED	Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent
NCT01151670	PHASE1	COMPLETED	Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Treating Patients With Brain Tumors
NCT06506578	Not specified	RECRUITING	Nausea Induced by Radiation of the Dorsal Vagal Complex for Benign Brain Tumors (NausiCAA)
NCT00592865	Not specified	TERMINATED	Risk Factors for Adult-Onset Brain Tumors
NCT04351035	Not specified	COMPLETED	National Wide Cross-sectional Study in Paediatric Central Nervous System Tumours in China – the CNOG-MC001 Registry
NCT04584086	Not specified	COMPLETED	Changes in the MRI Signal in Patients With Benign Tumors of the Brain and Meninges Treated With Proton Therapy: Impact of TEL and the Biological Dose Received
NCT05518942	Not specified	TERMINATED	Effects of SMR Neurofeedback on Insomnia in Patients With Benign Brain Tumors
NCT06098248	Not specified	TERMINATED	Evaluation of cCeLL-Ex Vivo Confocal Microscopy for Real-time Brain Tumor Diagnosis

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PIOGLITAZONE	4	1