Benign neoplasm of pituitary gland

Summary

Benign neoplasm of pituitary gland (MONDO:0021439) is a cancer with 2 GWAS associations across 9 studies. A subtype of benign reproductive system neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• GWAS associations: 2

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	benign neoplasm of pituitary gland
Mondo ID	MONDO:0021439
DOID	DOID:60009
ICD-10-CM	D35.2
ICD-11	1871539651
NCIT	C4782
SNOMED CT	92296004
UMLS	C0496901
MedGen	141679
GARD	0025319
Anatomy (UBERON)	UBERON:0000007
Is cancer (heuristic)	yes

Also known as: benign neoplasm of pituitary · benign neoplasm of the pituitary · benign neoplasm of the pituitary gland · benign pituitary gland neoplasm · benign pituitary gland tumor · benign pituitary gland tumour · benign pituitary neoplasm · benign pituitary tumor · benign pituitary tumour · benign tumor of pituitary · benign tumor of pituitary gland · benign tumor of the pituitary · benign tumor of the pituitary gland · benign tumour of pituitary · benign tumour of pituitary gland · benign tumour of the pituitary · benign tumour of the pituitary gland · pituitary gland benign neoplasm · pituitary neoplasms, benign · pituitary tumor, benign

Data availability: 2 GWAS associations (9 studies).

Disease family

This is a subtype of benign reproductive system neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › benign neoplasm › benign reproductive system neoplasm › benign neoplasm of pituitary gland

Related subtypes (5): benign female reproductive system neoplasm, benign male reproductive system neoplasm, paratesticular lipoma, adrenal rest tumor, sex cord-stromal benign neoplasm

Genetics & variants

GWAS landscape

2 GWAS associations across 9 studies. Top hits map to 0 distinct genes (as reported by GWAS).

Top associations by p-value

rsID	p-value	Gene	Risk allele	Odds ratio
rs374322849	3e-11	LINC01911 - RNU6-692P	C	3
rs147220408	2e-07	RP9P - RPL7AP78	?

Top studies (by case count)

Study	Lead author	Year	Cases	Controls	Title
GCST90477292	Verma A	2024	1,976	448,974	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90477291	Verma A	2024	989	120,785	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90479855	Verma A	2024	989	120,785	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90651924	Liu TY	2025	490	234,488	Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population.
GCST90481562	Verma A	2024	378	59,460	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90435681	Zhou W	2018	310	407,399	Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.
GCST90043611	Jiang L	2021	285	456,063	A generalized linear mixed model association tool for biobank-scale data.
GCST90043936	Jiang L	2021	209	456,139	A generalized linear mixed model association tool for biobank-scale data.
GCST90727173	Kim HI	2026	181	43,845	Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

Tier	Variants
Tier 1: coding	0
Tier 2: splice/UTR	0
Tier 3: regulatory	0
Tier 4: intronic/intergenic	2

MAF distribution

Bucket	Variants
common (>=0.05)	0
low_freq (0.01-0.05)	0
rare (<0.01)	1
unknown	1

Functional consequences

Consequence	Count
intergenic_variant	2

Top variants

rsID	Chr	Pos	Alleles	MAF	Consequence	Gene	p-value	Tier
rs374322849	2	147206551	C>T	0	intergenic_variant	LINC01911 - RNU6-692P	3e-11	Tier 4: intronic/intergenic
rs147220408	7	32947772	GTATC>G		intergenic_variant	RP9P - RPL7AP78	2e-07	Tier 4: intronic/intergenic

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.