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Atlas / Disease / Benign paroxysmal positional vertigo

Benign paroxysmal positional vertigo

disease
On this page

Also known as BPPVBRVfamilial benign recurrent vertigofamilial vestibulopathyvertigo, benign paroxysmal positionalvertigo, benign recurrentvestibulopathy, familial

Summary

Benign paroxysmal positional vertigo (MONDO:8000018) is a disease and 64 clinical trials. Top therapeutic interventions include cholecalciferol, betahistine, and lorazepam. A subtype of peripheral vertigo — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Clinical trials: 64

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical namebenign paroxysmal positional vertigo
Mondo IDMONDO:8000018
MeSHD065635
OMIM193007
DOIDDOID:13941
SNOMED CT111541001
UMLSC0155502
MedGen57837
Is cancer (heuristic)no

Also known as: benign paroxysmal positional vertigo · BPPV · BRV · familial benign recurrent vertigo · familial vestibulopathy · vertigo, benign paroxysmal positional · vertigo, benign recurrent · vestibulopathy, familial

Disease family

This is a subtype of peripheral vertigo. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › auditory system disorder › inner ear disorder › vestibular disorder › peripheral vertigo › benign paroxysmal positional vertigo

Related subtypes (3): endolymphatic hydrops, vertigo, benign recurrent, 2, vertigo, benign recurrent, 1

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 64.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified55
PHASE33
PHASE42
PHASE22
PHASE1/PHASE21
PHASE11

Top trials by phase / activity

NCTPhaseStatusTitle
NCT02031692PHASE4COMPLETEDEfficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in BPPV
NCT07075289PHASE4COMPLETEDComparing Oral Lumbrokinase DLBS1033 and Betahistine Mesylate in Benign Paroxysmal Positional Vertigo
NCT00182273PHASE3COMPLETEDCanalith Repositioning Procedure for BPPV in Primary Care
NCT01366430PHASE3COMPLETEDTreatment of Geotropic Horizontal Canal Benign Paroxysmal Positional Vertigo
NCT02029508PHASE3COMPLETEDThe Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo
NCT02046980PHASE2COMPLETEDTreatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo
NCT04578470PHASE2UNKNOWNBenign Paroxysmal Positional Vertigo (BPPV) in Older Patients
NCT05352555PHASE1/PHASE2COMPLETEDAutomated Robotic Maneuvering System (RMS) vs Manual Reposition Maneuver in Treatment of Benign Paroxysmal Positional Vertigo (BPPV)
NCT05748249PHASE1COMPLETEDEvaluation of the Efficacy of Vertistop® D and Vertistop® L in the Prevention of BPPV Recurrence
NCT05424302Not specifiedRECRUITINGEffect of Peripheral Vestibular Disease Location on Outcomes Following Home-based Virtual Reality Vestibular Therapy
NCT05834452Not specifiedACTIVE_NOT_RECRUITINGTreatment of Posterior Benign Paroxysmal Positional Vertigo With Mechanical Rotational Chair.
NCT05863949Not specifiedNOT_YET_RECRUITINGClinical Trial of Vit D and Calcium for Recurrent BPPV
NCT06001047Not specifiedRECRUITINGHead Acupuncture Treat Residual Symptoms After Canalith Repositioning Procedure for BPPV
NCT06228196Not specifiedRECRUITINGCohort Study of Clinical and Neuroimaging Characteristics for BPPV Patients in China
NCT06314581Not specifiedACTIVE_NOT_RECRUITINGEffect of a Multifaceted Educational Intervention on the Implementation of Evidence-based Practices for Benign Paroxysmal Positional Vertigo in an Emergency Department
NCT06625281Not specifiedRECRUITINGEffects of Epleys Maneuver Versus Semont-Plus Maneuver Combined with Brandt-Daroff Exercises on Dizziness and Quality of Life in Benign Paroxysmal Positional Vertigo
NCT06643702Not specifiedRECRUITINGPrevalence av BPPV Among Elderly in Primary Care
NCT06725966Not specifiedRECRUITINGPersonalized Treatment of Refractory BPPV
NCT06738823Not specifiedRECRUITINGEffect of Wii Fit Training in Comparison to Vestibular Rehabilitation Training on Balance in Patients With Benign Paroxysmal Postional Vertigo
NCT07111000Not specifiedRECRUITINGTesting the Epley Maneuver for Treating Dizziness in the Emergency Department
NCT07267988Not specifiedRECRUITINGAdditional Effects Of Brandt-Daroff Exercises With GANS Maneuver On Dizziness And Quality Of Life In Patients With BPPV
NCT07472998Not specifiedRECRUITINGHeart Rate Variability in Benign Paroxysmal Positional Vertigo
NCT07491965Not specifiedNOT_YET_RECRUITINGAssociation Between Benign Paroxysmal Positional Vertigo and Vitamin D Deficiency .
NCT07576088Not specifiedACTIVE_NOT_RECRUITINGMultimodal Physiotherapy for Balance and Vertigo in BPPV Patients
NCT00641797Not specifiedCOMPLETEDTreating Benign Paroxysmal Positional Vertigo (BPPV) in ED Patients
NCT00978809Not specifiedWITHDRAWNEffects of Physical Treatment on Postural Stability in Benign Paroxysmal Positional Vertigo (BPPV) Patients
NCT01529151Not specifiedCOMPLETEDEffectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in Individuals With Vertigo
NCT01822002Not specifiedUNKNOWNTreatment of Posterior Canal Type of Benign Paroxysmal Positional Vertigo
NCT01905800Not specifiedCOMPLETEDBPPV Treatment in Biaxial Rotational Chair
NCT02475239Not specifiedUNKNOWNEfficacy of Postural Restriction in Treating Benign Paroxysmal Positional Vertigo
NCT02701218Not specifiedUNKNOWNBPPV With CRP: Single Versus Multiple Cycles
NCT02809599Not specifiedCOMPLETEDEvidence Based Best Care Practice for Benign Paroxysmal Positional Vertigo
NCT03161470Not specifiedTERMINATEDEfficacy of a Mechanical Chair for Treatment of Benign Paroxysmal Positional Vertigo (BPPV)
NCT03230513Not specifiedCOMPLETEDComparison of Home-Based Exercise on the Posterior Canal Benign Paroxysmal Positional Vertigo Symptoms
NCT03425786Not specifiedCOMPLETEDBenign Paroxysmal Positional Vertigo (BPPV) Training for Sports Medicine Providers in a Pediatric Concussion Program
NCT03541018Not specifiedCOMPLETEDDifferent Treatments With the TRV Reposition Chair
NCT03643354Not specifiedCOMPLETEDEvaluation of the Prevalence of BPPV and Longterm Effects of Its Therapy Using the Rotundum Device in Retirement Homes
NCT03854084Not specifiedCOMPLETEDCranial Osteopathic Techniques on the Symptoms of Benign Paroxysmal Positional Vertigo
NCT03867019Not specifiedCOMPLETEDThe Cardiac Autonomic Control System Response to Vestibular Stimulation in Subjects With and Without BPPV
NCT03871413Not specifiedCOMPLETEDTRV-chair vs Manual Repositioning Maneuver in Treatment of Benign Paroxysmal Positional Vertigo

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
CHOLECALCIFEROL42
BETAHISTINE41
LORAZEPAM41
MECLIZINE41
BETAHISTINE MESILATE-11

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 19

This page pulls from 19 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogenccgwasgwas_studyhgncmedgenmeshmimmondomondochildmondoparentorphanetsctidumls