Beriberi

Summary

Beriberi (MONDO:0006676) is a disease and 18 clinical trials. Top therapeutic interventions include thiamine ion, magnesium sulfate, and metformin. A subtype of vitamin B deficiency — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 18

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	beriberi
Mondo ID	MONDO:0006676
EFO	EFO:1000837
MeSH	D001602
DOID	DOID:0070313, DOID:13725
ICD-10-CM	E51.1
ICD-11	632832064
NCIT	C34418
SNOMED CT	36656008
UMLS	C0005122
MedGen	543
MedDRA	10004482
Is cancer (heuristic)	no

Also known as: Beri Beri · thiamine deficiency · vitamin B1 deficiency

Disease family

This is a subtype of vitamin B deficiency. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › nutritional disorder › nutritional deficiency disease › vitamin deficiency disorder › vitamin B deficiency › beriberi

Related subtypes (2): pyridoxine deficiency anemia, vitamin B12 deficiency

Subtypes (2): dry beriberi, wet beriberi

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 18.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE4	5
PHASE1	3
PHASE2	2
PHASE2/PHASE3	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01524315	PHASE4	COMPLETED	Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery
NCT02464865	PHASE4	COMPLETED	Thiamin Deficiency in Obese Thai Children
NCT03746106	PHASE4	COMPLETED	The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine
NCT04453761	PHASE4	UNKNOWN	Thiamine Influenced on Substrate Energy Effectiveness in Indonesian Children Undergoing Cardiopulmonary Bypass
NCT04641104	PHASE4	COMPLETED	The Thiamine Administration After Cardiac Surgery Trial
NCT03466528	PHASE2/PHASE3	COMPLETED	Alcohol: Thiamine and or Magnesium 1
NCT03263442	PHASE2	COMPLETED	High Dose Intravenous Thiamine for the Prevention of Delirium in Allogeneic Hematopoietic Stem Cell Transplantation
NCT03550794	PHASE2	COMPLETED	Thiamine as a Renal Protective Agent in Septic Shock
NCT01864057	PHASE1	COMPLETED	Pharmacokinetics of Thiamine in Breastfeeding Mothers and Infants
NCT03122678	PHASE1	WITHDRAWN	Thiamine Supplementation in Patients With Septic Shock
NCT03228030	PHASE1	COMPLETED	Thiamine Supplementation in Heart Failure: a Pilot Randomized Controlled Crossover Trial
NCT06298344	EARLY_PHASE1	COMPLETED	The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease
NCT03554668	Not specified	COMPLETED	Systemic Inflammatory Response: Thiamine and Magnesium Status (Sir TaM Study)
NCT03616288	Not specified	COMPLETED	Trial of Thiamine Supplementation in Cambodia
NCT03626337	Not specified	COMPLETED	Thiamine Responsive Disorders (TRD) Among Infants in Lao PDR
NCT05390086	Not specified	COMPLETED	Further Development and Assessment of Tools to Measure Risk Factors for and Treatment of Thiamine Deficiency Disorders
NCT05480943	Not specified	COMPLETED	Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic Veterans
NCT05663164	Not specified	COMPLETED	Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS)

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
THIAMINE ION	4	22
MAGNESIUM SULFATE	4	1
METFORMIN	4	1
TRIMETHOPRIM	4	1