Bile duct cyst
diseaseOn this page
Also known as bile duct cystscholedochal cystcholedochal cystscholedochocelecongenital cystic dilatation of the biliary tract
Summary
Bile duct cyst (MONDO:0018805) is a disease and 14 clinical trials. Top therapeutic interventions include etomidate, midazolam, and propofol. A subtype of bile duct disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: 1-9 / 100 000 (Worldwide) [Orphanet-validated]
- Clinical trials: 14
Clinical features
Epidemiology
Prevalence records
1 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Prevalence at birth | 1-9 / 100 000 | 1 | Worldwide | Validated |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | bile duct cyst |
| Mondo ID | MONDO:0018805 |
| MeSH | D015529 |
| OMIM | 603003 |
| Orphanet | 480501 |
| DOID | DOID:899 |
| ICD-10-CM | Q44.4 |
| ICD-11 | 819487805 |
| SNOMED CT | 397868007 |
| UMLS | C0008340 |
| MedGen | 3037 |
| GARD | 0021973 |
| Is cancer (heuristic) | no |
Also known as: bile duct cysts · choledochal cyst · choledochal cysts · choledochocele · congenital cystic dilatation of the biliary tract
Disease family
This is a subtype of bile duct disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › hepatobiliary disorder › biliary tract disorder › bile duct disorder › bile duct cyst
Related subtypes (6): perforation of bile duct, cholestasis, common bile duct disorder, non-neoplastic bile duct disorder, bile duct neoplasm, fibrosis of bile duct
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 14.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 12 |
| PHASE4 | 1 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02013986 | PHASE4 | UNKNOWN | Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children |
| NCT06111872 | PHASE2 | COMPLETED | Ketamine-midazolam as a Sedative Agent in Endoscopic Retrograde Cholangiopancreatography. |
| NCT05620485 | Not specified | NOT_YET_RECRUITING | Timing of Operation in Children With a Prenatal Diagnosis of Choledochal Cyst |
| NCT06881004 | Not specified | RECRUITING | Biliary Dilatation National Special Disease Cohort in China |
| NCT07036848 | Not specified | RECRUITING | Efficacy and Safety of Surgical Treatment for Type IVa CBD |
| NCT07152496 | Not specified | NOT_YET_RECRUITING | Host-Microbe Interactions in Biliary Dilatation |
| NCT07530354 | Not specified | RECRUITING | A Longitudinal Cohort Study on the Changes of Physiological Mechanisms in Children After Biliary Tract Reconstruction |
| NCT02801500 | Not specified | UNKNOWN | Superior Bilioenteric Anastomosis by Magnetic Compressive Technique |
| NCT03774589 | Not specified | UNKNOWN | Bilioenteric Anastomosis by Magnetic Compressive Technique |
| NCT04319302 | Not specified | COMPLETED | Isolated Vascularized Gastric Tube Biliary Enteric Drainage: A Paediatric Case Series Experience. |
| NCT05181332 | Not specified | UNKNOWN | Predictive Models of Hepatic Decompensation and Survival Outcomes in Pediatric Patients With Cirrhosis |
| NCT06418490 | Not specified | UNKNOWN | The Application of Digital Intelligent Diagnostic and Therapeutic Technology in Biliary Dilation Diagnosis |
| NCT06716762 | Not specified | COMPLETED | Open vs. Laparoscopic Surgery for Pediatric Choledochal Cyst |
| NCT07028164 | Not specified | COMPLETED | Clinical Features and Prognosis of Asymptomatic Biliary Dilatation |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ETOMIDATE | 4 | 1 |
| MIDAZOLAM | 4 | 1 |
| PROPOFOL | 4 | 1 |
| S-ETOMIDATE | -1 | 1 |