Biliary dyskinesia

Summary

Biliary dyskinesia (MONDO:0005667) is a disease and 11 clinical trials. A subtype of duodenal disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 11

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	biliary dyskinesia
Mondo ID	MONDO:0005667
EFO	EFO:0007169
MeSH	D001657
DOID	DOID:4140
SNOMED CT	197432008
UMLS	C0005416
MedGen	2627
Anatomy (UBERON)	UBERON:0004915
Is cancer (heuristic)	no

Data availability: 1 HPO phenotype.

Disease family

This is a subtype of duodenal disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › small intestine disorder › duodenal disorder › biliary dyskinesia

Related subtypes (5): duodenal obstruction, duodenitis, duodenal ulcer, duodenogastric reflux, tumor of duodenum

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated or in trials for this disease

No drug has an approved disease-direct ChEMBL indication for this disease.

2 drugs in clinical trials for this disease (phase 2–3, investigational): efficacy not established — a trial record, not an indication.

Drug	Highest phase
Duloxetine	Phase 3
Amitriptyline	Phase 2

Clinical trials & evidence

Clinical trials

Clinical trials: 11.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE1	3
PHASE3	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07595003	PHASE3	RECRUITING	Efficacy, Safety, and Tolerability of 4-MUST, 128 mg Tablets in Chronic Cholecystitis and Biliary Dyskinesia
NCT06842966	PHASE2	RECRUITING	Efficacy, Safety, and Tolerability of 4-MUST Tablets in Chronic Cholecystitis and Biliary Dyskinesia
NCT07421011	PHASE1	RECRUITING	Pharmacokinetics, Bioequivalence, and Safety Study of Trimedat® 76,95 mg Orally Disintegrating Tablets and Trimedat® 100 mg Tablets in Healthy Volunteers.
NCT07594977	PHASE1	RECRUITING	Food-Effect, Single and Multiple Dose Pharmacokinetics, Safety and Tolerability Study of 4-MUST, 128 mg, Tablets in Healthy Volunteers
NCT00815438	PHASE1	WITHDRAWN	Transvaginal Cholecystectomy Using Endoscopic Assistance
NCT00737295	Not specified	TERMINATED	Ultrasound for Diagnosis of Biliary Dyskinesia
NCT00981604	Not specified	COMPLETED	Single Incision Laparoscopic Surgery (SILS) Versus Laparoscopic Cholecystectomy
NCT00984100	Not specified	COMPLETED	Natural Orifice Translumenal Endoscopic Surgery (NOTES) Transvaginal Cholecystectomy
NCT01195285	Not specified	TERMINATED	Single-Incision Laparoscopic Cholecystectomy Versus Traditional Laparoscopic Cholecystectomy
NCT04915651	Not specified	UNKNOWN	Gallbladder Cryoablation in High-Risk Patients
NCT05775133	Not specified	UNKNOWN	Feasibility and Utility of Artificial Intelligence (AI) / Machine Learning (ML) - Driven Advanced Intraoperative Visualization and Identification of Critical Anatomic Structures and Procedural Phases in Laparoscopic Cholecystectomy