Binge eating disorder
disease diseaseOn this page
Also known as binge eating
Summary
Binge eating disorder (MONDO:0005582) is a disease with 6 cohort genes (19 GWAS associations across 9 studies) and 250 clinical trials. Top therapeutic interventions include lisdexamfetamine, solriamfetol, and bupropion.
At a glance
- Cohort genes: 6
- GWAS associations: 19
- Clinical trials: 250
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | binge eating disorder |
| Mondo ID | MONDO:0005582 |
| EFO | EFO:0005924 |
| MeSH | D002032 |
| ICD-10-CM | F50.81 |
| ICD-11 | 1673294767 |
| NCIT | C97162 |
| SNOMED CT | 439960005 |
| UMLS | C0596170 |
| MedGen | 154543 |
| Is cancer (heuristic) | no |
Also known as: binge eating · binge eating disorder
Data availability: 19 GWAS associations (9 studies).
Disease family
Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › eating disorder › binge eating disorder
Related subtypes (5): rumination disorder, pica disease, anorexia nervosa, bulimia nervosa, avoidant/restrictive food intake disorder
Genetics & variants
GWAS landscape
19 GWAS associations across 9 studies. Top hits map to 9 distinct genes (as reported by GWAS).
Top associations by p-value
| rsID | p-value | Gene | Risk allele | Odds ratio |
|---|---|---|---|---|
| rs17789218 | 5e-10 | PRDX2P4 - SIM1 | C | 0.01 |
| rs79220007 | 9e-10 | HFE, H2BC4 | C | 0.02 |
| rs111940429 | 1e-08 | LINC01789 - LINC01885 | T | 2.86 |
| rs2275046 | 1e-08 | LRP11 | G | 0.01 |
| rs726170 | 3e-08 | ARHGAP8, PRR5-ARHGAP8 | T | 1.92 |
| rs17810023 | 9e-08 | RPL17P25 - RPSAP72 | T | 3.85 |
| rs7904579 | 1e-07 | CUBN | G | 1.56 |
| rs7337127 | 3e-07 | ATP6V1G1P7 - RPL7P45 | T | 1.75 |
| rs145763646 | 3e-07 | SLC25A26 | A | 2.08 |
| rs7412 | 4e-07 | APOE | T | 0.02 |
| rs1950038 | 7e-07 | LIN28AP1 - CACYBPP2 | T | 1.6 |
| rs6006893 | 9e-07 | ARHGAP8, PRR5-ARHGAP8 | ? | 1.99 |
| rs10198175 | 1e-06 | LINC02850 - APOB | ? | 1.92 |
| rs73057489 | 1e-06 | RPL7P40 - PSMC1P8 | C | 2 |
| rs182107583 | 1e-06 | MMADHC-DT | C | 3.23 |
| rs76087671 | 1e-06 | LINC01721 - GAPDHP53 | T | 2.33 |
| rs13233490 | 4e-06 | NXPH1 - GAPDHP68 | ? | 4.89 |
Top studies (by case count)
| Study | Lead author | Year | Cases | Controls | Title |
|---|---|---|---|---|---|
| GCST90078638 | Backman JD | 2021 | 604 | 43,660 | Exome sequencing and analysis of 454,787 UK Biobank participants. |
| GCST90082624 | Backman JD | 2021 | 604 | 43,660 | Exome sequencing and analysis of 454,787 UK Biobank participants. |
| GCST005386 | McElroy SL | 2018 | 398 | 1,811 | Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8. |
| GCST005387 | McElroy SL | 2018 | 398 | 1,231 | Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8. |
| GCST002419 | Winham SJ | 2014 | 206 | 1,034 | Bipolar disorder with comorbid binge eating history: a genome-wide association study implicates APOB. |
| GCST002420 | Winham SJ | 2014 | 206 | 0 | Bipolar disorder with comorbid binge eating history: a genome-wide association study implicates APOB. |
| GCST90328136 | Burstein D | 2023 | 0 | 0 | Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism. |
| GCST90328137 | Burstein D | 2023 | 0 | 0 | Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism. |
| GCST90328138 | Burstein D | 2023 | 0 | 0 | Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism. |
Variant details and genetic-evidence tiers
Tier distribution (top 50 variants)
| Tier | Variants |
|---|---|
| Tier 1: coding | 1 |
| Tier 2: splice/UTR | 1 |
| Tier 3: regulatory | 0 |
| Tier 4: intronic/intergenic | 15 |
MAF distribution
| Bucket | Variants |
|---|---|
| common (>=0.05) | 14 |
| low_freq (0.01-0.05) | 3 |
| rare (<0.01) | 0 |
| unknown | 0 |
Functional consequences
| Consequence | Count |
|---|---|
| intron_variant | 11 |
| intergenic_variant | 4 |
| 3_prime_UTR_variant | 1 |
| missense_variant | 1 |
Top variants
| rsID | Chr | Pos | Alleles | MAF | Consequence | Gene | p-value | Tier |
|---|---|---|---|---|---|---|---|---|
| rs17789218 | 6 | 100152221 | T>A,C | 0.25 | intron_variant | PRDX2P4 - SIM1 | 5e-10 | Tier 4: intronic/intergenic |
| rs79220007 | 6 | 26098246 | T>C | 0.06 | 3_prime_UTR_variant | HFE, H2BC4 | 9e-10 | Tier 2: splice/UTR |
| rs111940429 | 2 | 107366232 | C>A,T | 0.04 | intron_variant | LINC01789 - LINC01885 | 1e-08 | Tier 4: intronic/intergenic |
| rs2275046 | 6 | 149835865 | A>C,G,T | 0.36 | intron_variant | LRP11 | 1e-08 | Tier 4: intronic/intergenic |
| rs726170 | 22 | 44855931 | C>T | 0.12 | intron_variant | ARHGAP8, PRR5-ARHGAP8 | 3e-08 | Tier 4: intronic/intergenic |
| rs17810023 | 6 | 80443056 | C>T | 0.02 | intron_variant | RPL17P25 - RPSAP72 | 9e-08 | Tier 4: intronic/intergenic |
| rs7904579 | 10 | 17089754 | G>A,C | 0.37 | intron_variant | CUBN | 1e-07 | Tier 4: intronic/intergenic |
| rs7337127 | 13 | 104623579 | C>A,G,T | 0.15 | intron_variant | ATP6V1G1P7 - RPL7P45 | 3e-07 | Tier 4: intronic/intergenic |
| rs145763646 | 3 | 66173478 | G>A,T | 0.1 | intron_variant | SLC25A26 | 3e-07 | Tier 4: intronic/intergenic |
| rs7412 | 19 | 44908822 | C>T | 0.08 | missense_variant | APOE | 4e-07 | Tier 1: coding |
| rs1950038 | 2 | 183579642 | T>A,C | 0.3 | intergenic_variant | LIN28AP1 - CACYBPP2 | 7e-07 | Tier 4: intronic/intergenic |
| rs6006893 | 22 | 44858015 | C>T | 0.05 | intron_variant | ARHGAP8, PRR5-ARHGAP8 | 9e-07 | Tier 4: intronic/intergenic |
| rs10198175 | 2 | 20934123 | A>C,G,T | 0.05 | intergenic_variant | LINC02850 - APOB | 1e-06 | Tier 4: intronic/intergenic |
| rs73057489 | 12 | 17370820 | A>C | 0.07 | intergenic_variant | RPL7P40 - PSMC1P8 | 1e-06 | Tier 4: intronic/intergenic |
| rs182107583 | 2 | 149675023 | A>C | 0.04 | intron_variant | MMADHC-DT | 1e-06 | Tier 4: intronic/intergenic |
| rs76087671 | 20 | 24330541 | C>A,G,T | 0.05 | intron_variant | LINC01721 - GAPDHP53 | 1e-06 | Tier 4: intronic/intergenic |
| rs13233490 | 7 | 9030639 | G>C | 0.05 | intergenic_variant | NXPH1 - GAPDHP68 | 4e-06 | Tier 4: intronic/intergenic |
Genes & proteins
Mendelian disease overlap and somatic drivers
GenCC: 0 · Orphanet: 3 · OMIM-shared: 0 · Dual-evidence (GWAS+Mendelian): 0
Orphanet rare-disease linkage (cohort genes)
| Gene | Orphanet ID | Rare disease |
|---|---|---|
| SLC25A26 | Orphanet:466784 | Neonatal severe cardiopulmonary failure due to mitochondrial methylation defect |
| CUBN | Orphanet:35858 | Imerslund-Gräsbeck syndrome |
| APOB | Orphanet:391665 | Homozygous familial hypercholesterolemia |
Cohort genes → proteins
6 cohort genes, 5 distinct canonical proteins.
Evidence partition
| Subset | Genes |
|---|---|
| gwas_only | 6 |
Cohort genes (full)
| Symbol | HGNC | Ensembl | UniProt | Name | Evidence |
|---|---|---|---|---|---|
| SLC25A26 | HGNC:20661 | ENSG00000144741 | Q70HW3 | Mitochondrial S-adenosylmethionine carrier protein | gwas |
| CUBN | HGNC:2548 | ENSG00000107611 | O60494 | Cubilin | gwas |
| PRR5 | HGNC:31682 | ENSG00000186654 | P85299 | Proline-rich protein 5 | gwas |
| PER3P1 | HGNC:54525 | ENSG00000271077 | PER3 pseudogene 1 | gwas | |
| APOB | HGNC:603 | ENSG00000084674 | P04114 | Apolipoprotein B-100 | gwas |
| ARHGAP8 | HGNC:677 | ENSG00000241484 | P85298 | Rho GTPase-activating protein 8 | gwas |
Cohort function summary
Lead sentence per gene, UniProt-curated.
| Symbol | Protein name | Function (lead sentence) |
|---|---|---|
| SLC25A26 | Mitochondrial S-adenosylmethionine carrier protein | Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L-homocysteine antiporter. |
| CUBN | Cubilin | Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. |
| PRR5 | Proline-rich protein 5 | Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream… |
| APOB | Apolipoprotein B-100 | Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). |
| ARHGAP8 | Rho GTPase-activating protein 8 | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. |
Protein-family classification
Druggable: 0 · Difficult: 0 · Unknown: 6 · Druggable fraction: 0.0
Family distribution
Cohort families vs a genome-wide background (hypergeometric, BH-FDR; fold = observed/expected). Counts kept; sorted by enrichment, so the catch-all Other/Unknown bucket no longer leads.
| Family | Genes | Fold | FDR |
|---|---|---|---|
| Other/Unknown | 6 | 1.8× | 0.030 |
Per-gene assignment
| Symbol | Family | Druggable? | EC | InterPro (top 3) |
|---|---|---|---|---|
| SLC25A26 | Other/Unknown | no | MCP_transmembrane, MCP_dom_sf | |
| CUBN | Other/Unknown | no | EGF-type_Asp/Asn_hydroxyl_site, EGF, CUB_dom | |
| PRR5 | Other/Unknown | no | Bit61/PRR5, Cullin_repeat-like_dom_sf | |
| PER3P1 | Other/Unknown | no | ||
| APOB | Other/Unknown | no | Vitellogenin_N, Lipid_transpt_open_b-sht, Lipovitellin_superhlx_dom | |
| ARHGAP8 | Other/Unknown | no | RhoGAP_dom, CRAL-TRIO_dom, Rho_GTPase_activation_prot |
Expression context
Cohort genes with no expression data: 0.
5 cohort genes are a single-cell marker in ≥1 SCXA experiment.
Breadth distribution (Bgee present_calls)
| Bucket | Genes |
|---|---|
| narrow (1-5 tissues) | 0 |
| moderate (6-20) | 1 |
| broad (>20) | 5 |
| unknown | 0 |
Top tissues across cohort
| Tissue | Cohort genes |
|---|---|
| apex of heart | 1 |
| gastrocnemius | 1 |
| muscle of leg | 1 |
| adult organism | 1 |
| kidney epithelium | 1 |
| nephron tubule | 1 |
| adenohypophysis | 1 |
| granulocyte | 1 |
| spleen | 1 |
| male germ line stem cell (sensu Vertebrata) in testis | 1 |
| smooth muscle tissue | 1 |
| sural nerve | 1 |
| ileal mucosa | 1 |
| jejunal mucosa | 1 |
| liver | 1 |
| left lobe of thyroid gland | 1 |
| metanephros cortex | 1 |
| right uterine tube | 1 |
Per-gene tissue summary (top 30)
| Symbol | Bgee breadth | FANTOM5 breadth | SCXA | Top tissues |
|---|---|---|---|---|
| SLC25A26 | 134 | ubiquitous | marker | gastrocnemius, muscle of leg, apex of heart |
| CUBN | 188 | broad | marker | adult organism, nephron tubule, kidney epithelium |
| PRR5 | 240 | broad | marker | spleen, adenohypophysis, granulocyte |
| PER3P1 | 7 | yes | male germ line stem cell (sensu Vertebrata) in testis, sural nerve, smooth muscle tissue | |
| APOB | 116 | broad | marker | jejunal mucosa, liver, ileal mucosa |
| ARHGAP8 | 179 | broad | marker | right uterine tube, metanephros cortex, left lobe of thyroid gland |
Protein interactions among cohort
Intra-cohort edges: 1.
Hub genes (top 10 by interactor count)
| Symbol | Interactor count |
|---|---|
| APOB | 5,244 |
| CUBN | 1,193 |
| SLC25A26 | 705 |
| PRR5 | 656 |
| ARHGAP8 | 498 |
| PER3P1 | 0 |
Intra-cohort edges
| A | B | Sources |
|---|---|---|
| ARHGAP8 | PRR5 | string_interaction |
Structural data
PDB: 2 · AlphaFold-only: 3 · No structure: 1
Cohort genes with PDB structures (top 30)
| Symbol | UniProt | PDB entries |
|---|---|---|
| APOB | P04114 | 8 |
| CUBN | O60494 | 2 |
AlphaFold-only cohort genes (top 30 by pLDDT)
| Symbol | UniProt | pLDDT |
|---|---|---|
| SLC25A26 | Q70HW3 | 88.04 |
| ARHGAP8 | P85298 | 76.51 |
| PRR5 | P85299 | 69.59 |
Function
Pathway analysis
Distinct Reactome pathways touched by cohort: 58. Enrichment computed across 6 evidence-associated genes (5 with Reactome annotation).
Pathways by enrichment
Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 5 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.
| Pathway | Cohort genes | Fold | FDR | Sample cohort genes |
|---|---|---|---|---|
| Defective AMN causes MGA1 | 1 | 761.3× | 0.017 | CUBN |
| Defective CUBN causes MGA1 | 1 | 761.3× | 0.017 | CUBN |
| Scavenging by Class H Receptors | 1 | 571.0× | 0.017 | APOB |
| VLDL assembly | 1 | 456.8× | 0.017 | APOB |
| HDL clearance | 1 | 456.8× | 0.017 | CUBN |
| Chylomicron clearance | 1 | 456.8× | 0.017 | APOB |
| Scavenging by Class F Receptors | 1 | 380.7× | 0.017 | APOB |
| LDL remodeling | 1 | 380.7× | 0.017 | APOB |
| VLDL clearance | 1 | 380.7× | 0.017 | APOB |
| Chylomicron assembly | 1 | 228.4× | 0.021 | APOB |
| Chylomicron remodeling | 1 | 228.4× | 0.021 | APOB |
| Uptake of dietary cobalamins into enterocytes | 1 | 228.4× | 0.021 | CUBN |
| Scavenging by Class B Receptors | 1 | 207.6× | 0.021 | APOB |
| Vitamin D (calciferol) metabolism | 1 | 175.7× | 0.024 | CUBN |
| SLC-mediated transport of organic cations | 1 | 152.3× | 0.024 | SLC25A26 |
| Plasma lipoprotein assembly | 1 | 142.8× | 0.024 | APOB |
| Dengue virus modulates apoptosis | 1 | 142.8× | 0.024 | PRR5 |
| Platelet sensitization by LDL | 1 | 134.3× | 0.024 | APOB |
| Scavenging by Class A Receptors | 1 | 120.2× | 0.025 | APOB |
| Binding and Uptake of Ligands by Scavenger Receptors | 1 | 108.8× | 0.025 | APOB |
| LDL clearance | 1 | 108.8× | 0.025 | APOB |
| Regulation of TLR by endogenous ligand | 1 | 99.3× | 0.025 | APOB |
| Plasma lipoprotein remodeling | 1 | 95.2× | 0.025 | APOB |
| Plasma lipoprotein clearance | 1 | 95.2× | 0.025 | APOB |
| Constitutive Signaling by AKT1 E17K in Cancer | 1 | 84.6× | 0.027 | PRR5 |
| VEGFR2 mediated vascular permeability | 1 | 81.6× | 0.027 | PRR5 |
| CD28 dependent PI3K/Akt signaling | 1 | 78.8× | 0.027 | PRR5 |
| Metabolism of fat-soluble vitamins | 1 | 76.1× | 0.027 | APOB |
| Transport of small molecules | 2 | 10.1× | 0.029 | SLC25A26, APOB |
| Regulation of TP53 Degradation | 1 | 58.6× | 0.033 | PRR5 |
GO biological processes by enrichment
Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 5 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.
| GO term | Cohort genes | Fold | FDR | Sample cohort genes |
|---|---|---|---|---|
| lipoprotein transport | 2 | 396.5× | 4e-04 | CUBN, APOB |
| S-adenosyl-L-methionine transport | 1 | 3370.4× | 0.003 | SLC25A26 |
| macromolecule methylation | 1 | 3370.4× | 0.003 | SLC25A26 |
| mitochondrial S-adenosyl-L-methionine transmembrane transport | 1 | 3370.4× | 0.003 | SLC25A26 |
| cholesterol metabolic process | 2 | 78.4× | 0.003 | CUBN, APOB |
| establishment of localization in cell | 2 | 64.2× | 0.003 | CUBN, APOB |
| negative regulation of endocytic recycling | 1 | 1123.5× | 0.006 | ARHGAP8 |
| triglyceride mobilization | 1 | 842.6× | 0.007 | APOB |
| cellular response to lipoprotein particle stimulus | 1 | 674.1× | 0.008 | APOB |
| lipoprotein biosynthetic process | 1 | 561.7× | 0.008 | APOB |
| positive regulation of cholesterol storage | 1 | 481.5× | 0.008 | APOB |
| lipoprotein catabolic process | 1 | 481.5× | 0.008 | APOB |
| cobalamin transport | 1 | 374.5× | 0.010 | CUBN |
| cobalamin metabolic process | 1 | 306.4× | 0.010 | CUBN |
| TORC2 signaling | 1 | 306.4× | 0.010 | PRR5 |
| regulation of cholesterol biosynthetic process | 1 | 306.4× | 0.010 | APOB |
| positive regulation of lipid storage | 1 | 280.9× | 0.010 | APOB |
| very-low-density lipoprotein particle assembly | 1 | 240.7× | 0.011 | APOB |
| low-density lipoprotein particle remodeling | 1 | 210.7× | 0.012 | APOB |
| low-density lipoprotein particle clearance | 1 | 198.3× | 0.012 | APOB |
| positive regulation of macrophage derived foam cell differentiation | 1 | 168.5× | 0.013 | APOB |
| triglyceride catabolic process | 1 | 160.5× | 0.013 | APOB |
| cholesterol transport | 1 | 146.5× | 0.014 | APOB |
| artery morphogenesis | 1 | 134.8× | 0.014 | APOB |
| tissue homeostasis | 1 | 112.3× | 0.017 | CUBN |
| cholesterol efflux | 1 | 105.3× | 0.017 | APOB |
| cellular response to nutrient levels | 1 | 93.6× | 0.019 | PRR5 |
| fertilization | 1 | 62.4× | 0.027 | APOB |
| receptor-mediated endocytosis | 1 | 44.4× | 0.036 | CUBN |
| phosphatidylinositol 3-kinase/protein kinase B signal transduction | 1 | 42.1× | 0.037 | PRR5 |
Therapeutics
Drugs indicated or in trials for this disease
No drug has an approved disease-direct ChEMBL indication for this disease.
3 drugs in clinical trials for this disease (phase 2–3, investigational): efficacy not established — a trial record, not an indication.
| Drug | Highest phase |
|---|---|
| Topiramate | Phase 3 |
| Drospirenone | Phase 2 |
| Ethinyl Estradiol | Phase 2 |
Drug target analysis
Approved (phase 4): 0 · Phase ≥3: 0 · Phased (≥1): 0 · Undrugged: 6
Druggability breadth: 1 of 6 evidence-associated genes (17%) have a ChEMBL target (buckets above are over the deeply-mined display cohort).
Top cohort targets by molecule count
| Symbol | Molecules | Max phase |
|---|---|---|
| SLC25A26 | 0 | 0 |
| CUBN | 0 | 0 |
| PRR5 | 0 | 0 |
| PER3P1 | 0 | 0 |
| APOB | 0 | 0 |
| ARHGAP8 | 0 | 0 |
Bioactivity and enzyme data
Enzyme cohort genes (≥1 EC): 0.
Cohort genes with ChEMBL bioactivity (full, sorted by assay count)
| Symbol | Assays | Type breakdown |
|---|---|---|
| APOB | 1 | Binding:1 |
Pharmacogenomics
Cohort genes with a PharmGKB record: 5; with CPIC/DPWG dosing guidelines: 0.
No cohort gene has a CPIC/DPWG genotype-guided dosing guideline (PharmGKB).
Chemical tractability of cohort targets
0 approved/phased compounds have measured bioactivity against a cohort gene (and aren’t yet in disease-level trials). This is a research / tractability signal, NOT a therapeutic recommendation — a bioactivity row often reflects off-target or screening binding (e.g. promiscuous kinase inhibitors against a cohort kinase), implying no disease mechanism.
Druggability pyramid
Cohort genes binned by druggability tier (high → low):
| Tier | Definition | Genes | Symbols |
|---|---|---|---|
| A | Approved (phase 4 drug) | 0 | |
| B | Phased (≥1) drug, not yet approved | 0 | |
| C | Druggable family + PDB, no drug | 0 | |
| D | Druggable family + AlphaFold only, no drug | 0 | |
| E | Difficult family or no structure, no drug | 6 | SLC25A26, CUBN, PRR5, PER3P1, APOB, ARHGAP8 |
Undrugged target profiles
6 cohort genes are undrugged. Ranked by ‘starting-point quality’ (assay depth + drugged-partner adjacency).
| Symbol | ChEMBL assays | Drugged partners (top 3) |
|---|---|---|
| SLC25A26 | 0 | — |
| CUBN | 0 | — |
| PRR5 | 0 | — |
| PER3P1 | 0 | — |
| APOB | 1 | — |
| ARHGAP8 | 0 | — |
Clinical trials & evidence
Clinical trials
Clinical trials: 250.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 183 |
| PHASE2 | 18 |
| PHASE3 | 17 |
| PHASE2/PHASE3 | 14 |
| PHASE4 | 7 |
| PHASE1/PHASE2 | 4 |
| PHASE1 | 4 |
| EARLY_PHASE1 | 3 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00327834 | PHASE4 | COMPLETED | Atomoxetine in the Treatment of Binge Eating Disorder |
| NCT00330655 | PHASE4 | COMPLETED | An Open-Label Trial of Memantine in the Treatment of Binge Eating Disorder |
| NCT00516919 | PHASE4 | COMPLETED | Study of Behavioral Weight Loss Therapy for Obesity and Binge Eating in Monolingual Hispanic Persons |
| NCT00537810 | PHASE4 | COMPLETED | Treatment of Binge Eating in Obese Patients in Primary Care |
| NCT00607789 | PHASE4 | COMPLETED | Study of Duloxetine vs Placebo in Treatment of Binge Eating Disorder With Depression |
| NCT04602936 | PHASE4 | UNKNOWN | Solriamfetol in Binge Eating Disorder |
| NCT05560529 | PHASE4 | COMPLETED | Dialectical Behavioral Therapy As A Therapeutic Tool In Patients With Binge Eating Disorder |
| NCT06413433 | PHASE3 | RECRUITING | Elucidating TAAR-1, Dopamine, and Norepinephrine in Binge Eating Disorder Using Solriamfetol |
| NCT06878976 | PHASE3 | ENROLLING_BY_INVITATION | Open-Label Safety Study of Solriamfetol in Subjects With Binge Eating Disorder |
| NCT00032760 | PHASE2/PHASE3 | COMPLETED | Meditation-Based Treatment for Binge Eating Disorder |
| NCT00210808 | PHASE2/PHASE3 | COMPLETED | A Study of the Effectiveness and Safety of Topiramate in the Treatment of Moderate to Severe Binge-eating Disorder Associated With Obesity |
| NCT00277641 | PHASE3 | COMPLETED | Lamotrigine in the Treatment of Binge Eating Disorder Associated With Obesity |
| NCT00307619 | PHASE3 | COMPLETED | An Efficacy and Tolerability Study for Topiramate in Obese Patients With Binge Eating Disorder. |
| NCT00402584 | PHASE3 | COMPLETED | A Study to Examine the Efficacy and Safety of Meridia® (Sibutramine Hydrochloride) in Binge-Eating Disorder |
| NCT00414167 | PHASE2/PHASE3 | COMPLETED | Craving, Binge Eating and Obesity |
| NCT00511940 | PHASE2/PHASE3 | COMPLETED | Acamprosate in the Treatment of Binge-Eating Disorder |
| NCT00514995 | PHASE2/PHASE3 | COMPLETED | Sodium Oxybate in the Treatment of Binge Eating Disorder |
| NCT01010789 | PHASE3 | COMPLETED | Armodafinil in Binge Eating Disorder (BED) |
| NCT01090713 | PHASE3 | COMPLETED | Efficacy Study of Lisdexamfetamine to Treat Binge Eating Disorder |
| NCT01106053 | PHASE3 | WITHDRAWN | Pramipexole for Binge Eating Disorder |
| NCT01567670 | PHASE2/PHASE3 | UNKNOWN | Clinical Trial on Binge Eating Disorder, Treatment With Naloxone Spray |
| NCT01657019 | PHASE3 | COMPLETED | Open Label Extension in Adults With Binge Eating Disorder (BED) |
| NCT01693237 | PHASE2/PHASE3 | UNKNOWN | Improving Patient Outcome in Group Therapy for Eating Disorders |
| NCT01718483 | PHASE3 | COMPLETED | SPD489 in Adults Aged 18-55 Years With Moderate to Severe Binge Eating Disorder |
| NCT01718509 | PHASE3 | COMPLETED | SPD489 in Adults Aged 18-55 Years With Moderate to Severe Binge Eating Disorder |
| NCT02009163 | PHASE3 | COMPLETED | Evaluate the Maintenance of Efficacy of SPD489 in Adults Aged 18-55 Years With Moderate to Severe Binge Eating Disorder |
| NCT02564588 | PHASE2/PHASE3 | COMPLETED | Dasotraline Binge Eating Disorder Study |
| NCT02684279 | PHASE3 | COMPLETED | Dasotraline Binge Eating Disorder Extension Study |
| NCT03045341 | PHASE2/PHASE3 | COMPLETED | Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Acute Treatment |
| NCT03047005 | PHASE2/PHASE3 | COMPLETED | Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Maintenance Therapy |
| NCT03063606 | PHASE2/PHASE3 | COMPLETED | Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Specialist Treatment |
| NCT03107026 | PHASE3 | COMPLETED | A Study to Evaluate a Drug (Dasotraline) on the Safety, Effectiveness and How Well the Body Tolerates it, in Adults With Moderate to Severe Binge Eating Disorder |
| NCT03279731 | PHASE3 | TERMINATED | Binge Eating Liraglutide Intervention |
| NCT03539900 | PHASE2/PHASE3 | COMPLETED | Efficacy and Mechanisms of Naltrexone+Bupropion for Binge Eating Disorder |
| NCT03717493 | PHASE2/PHASE3 | COMPLETED | Deficits in Emotion Regulation Skills as a Maintaining Factor in Binge Eating Disorder |
| NCT03924193 | PHASE3 | COMPLETED | Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Acute Treatment |
| NCT03926052 | PHASE3 | COMPLETED | Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Maintenance Treatment |
| NCT03946111 | PHASE2/PHASE3 | COMPLETED | Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Medication Change for Non-Responders |
| NCT05664516 | PHASE2 | RECRUITING | A Study of the Effects of Oxytocin in Adults With Binge-eating Disorder |
| NCT06817863 | PHASE1/PHASE2 | RECRUITING | A Self-Guided Mobile Intervention for Adults With Binge Eating and Obesity |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| LISDEXAMFETAMINE | 4 | 9 |
| SOLRIAMFETOL | 4 | 9 |
| BUPROPION | 4 | 7 |
| ATOMOXETINE | 4 | 3 |
| OXYBATE | 4 | 3 |
| PHENTERMINE | 4 | 3 |
| SIBUTRAMINE | 4 | 3 |
| ORLISTAT | 4 | 2 |
| TOPIRAMATE | 4 | 2 |
| ACAMPROSATE | 4 | 1 |
| ARMODAFINIL | 4 | 1 |
| DULOXETINE | 4 | 1 |
| LAMOTRIGINE | 4 | 1 |
| MEMANTINE | 4 | 1 |
| NALOXONE | 4 | 1 |
| PRAMIPEXOLE | 4 | 1 |
| VORTIOXETINE | 4 | 1 |
| DASOTRALINE | 3 | 3 |
| CENTANAFADINE | 3 | 1 |
| DEXPRAMIPEXOLE | 3 | 1 |
| GHRELIN | 3 | 1 |
| MIDOMAFETAMINE | 3 | 1 |
| GLP-1 | 2 | 1 |
| CHROMIUM PICOLINATE | 1 | 1 |
| GLUCAGON-LIKE PEPTIDE 1 | 1 | 1 |
| CHEMBL4227980 | 0 | 3 |
| CHEMBL425281 | 0 | 1 |
| CHEMBL5410324 | 0 | 1 |
| CHEMBL1201343 | 0 | 1 |
| CHEMBL4227573 | 0 | 1 |
Related Atlas pages
- Cohort genes: SLC25A26, CUBN, PRR5, APOB, ARHGAP8
- Drugs: Lisdexamfetamine, Solriamfetol, Bupropion, Atomoxetine, Oxybate, Phentermine, Sibutramine, Orlistat, Topiramate, Acamprosate, Armodafinil, Duloxetine, Lamotrigine, Memantine, Naloxone, Pramipexole, Vortioxetine, Dasotraline, Centanafadine, Dexpramipexole, Ghrelin, Midomafetamine