Binocular vision disease
disease diseaseOn this page
Also known as binocular vision disordersimultaneous visual perception without fusion
Summary
Binocular vision disease (MONDO:0001564) is a disease with 1 GWAS associations across 2 studies and 10 clinical trials. A subtype of vision disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- GWAS associations: 1
- Clinical trials: 10
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | binocular vision disease |
| Mondo ID | MONDO:0001564 |
| EFO | EFO:0009535 |
| DOID | DOID:12667 |
| NCIT | C34422 |
| SNOMED CT | 83275001 |
| UMLS | C0005461 |
| MedGen | 571 |
| Is cancer (heuristic) | no |
Also known as: binocular vision disorder · simultaneous visual perception without fusion
Data availability: 1 GWAS association (2 studies).
Disease family
This is a subtype of vision disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › perceptual disorders › vision disorder › binocular vision disease
Related subtypes (6): visual agnosia, amblyopia, color vision disorder, visual pathway disorder, blindness (disorder), Alice in Wonderland syndrome
Subtypes (1): abnormal retinal correspondence
Genetics & variants
GWAS landscape
1 GWAS associations across 2 studies. Top hits map to 0 distinct genes (as reported by GWAS).
Top associations by p-value
| rsID | p-value | Gene | Risk allele | Odds ratio |
|---|---|---|---|---|
| rs559355187 | 5e-07 | RPS23 - ATP6AP1L | ? |
Top studies (by case count)
| Study | Lead author | Year | Cases | Controls | Title |
|---|---|---|---|---|---|
| GCST90652141 | Liu TY | 2025 | 1,067 | 213,222 | Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population. |
| GCST90473448 | UK Biobank Whole-Genome Sequencing Consortium | 2025 | 242 | 458,198 | Whole-genome sequencing of 490,640 UK Biobank participants. |
Variant details and genetic-evidence tiers
Tier distribution (top 50 variants)
| Tier | Variants |
|---|---|
| Tier 1: coding | 0 |
| Tier 2: splice/UTR | 0 |
| Tier 3: regulatory | 0 |
| Tier 4: intronic/intergenic | 1 |
MAF distribution
| Bucket | Variants |
|---|---|
| common (>=0.05) | 0 |
| low_freq (0.01-0.05) | 0 |
| rare (<0.01) | 0 |
| unknown | 1 |
Functional consequences
| Consequence | Count |
|---|---|
| intergenic_variant | 1 |
Top variants
| rsID | Chr | Pos | Alleles | MAF | Consequence | Gene | p-value | Tier |
|---|---|---|---|---|---|---|---|---|
| rs559355187 | 5 | 82292368 | TGAAA>T | intergenic_variant | RPS23 - ATP6AP1L | 5e-07 | Tier 4: intronic/intergenic |
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 10.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 9 |
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00338611 | PHASE3 | UNKNOWN | Convergence Insufficiency Treatment Trial (CITT) |
| NCT02651389 | Not specified | COMPLETED | Evaluation of Tests Performance on a New Digital Orthoptic Platform |
| NCT03592615 | Not specified | COMPLETED | Binocular Vision Anomalies After Cataract and Refractive Surgery |
| NCT03603301 | Not specified | UNKNOWN | Vision in Children Born to Opioid-dependent Methadone-maintained Mothers |
| NCT04086524 | Not specified | COMPLETED | A Patch Free Treatment for Young Children With Amblyopia |
| NCT05070767 | Not specified | COMPLETED | Neurolens Headache Study |
| NCT05087563 | Not specified | TERMINATED | Neurolens Convergence Insufficiency Study |
| NCT05208658 | Not specified | UNKNOWN | Characteristics of the Vergence Responses of Binocularly Normal Subjects After a Vision Therapy Protocol |
| NCT05522595 | Not specified | UNKNOWN | Performance and Safety Evaluation of the S360 Medical Device Software. |
| NCT05633212 | Not specified | UNKNOWN | Binocular Vision Alternations and fMRI Activation After ICL Implantation for High Myopia |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.