Borderline epithelial tumor of ovary

Summary

Borderline epithelial tumor of ovary (MONDO:0016093) is a cancer and 6 clinical trials. Top therapeutic interventions include selumetinib, belinostat, and ucn-01. A subtype of ovarian epithelial tumor — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 6

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	borderline epithelial tumor of ovary
Mondo ID	MONDO:0016093
EFO	EFO:1000140
Orphanet	206473
NCIT	C4783
SNOMED CT	764791008
UMLS	C3665489
MedGen	777110
GARD	0009363
Is cancer (heuristic)	yes

Also known as: borderline epithelial neoplasm of ovary · borderline epithelial neoplasm of the ovary · borderline epithelial tumor of ovary · borderline epithelial tumor of the ovary · borderline epithelial tumour of the ovary · borderline ovarian epithelial neoplasm · borderline ovarian epithelial tumor · borderline ovarian epithelial tumour · borderline ovarian surface epithelial-stromal tumor · borderline ovarian surface epithelial-stromal tumour · epithelial neoplasm of ovary of borderline malignancy · epithelial neoplasm of the ovary of borderline malignancy · epithelial ovarian neoplasm of borderline malignancy · epithelial ovarian tumor of borderline malignancy · epithelial ovarian tumour of borderline malignancy · epithelial tumor of ovary of borderline malignancy · epithelial tumor of the ovary of borderline malignancy · epithelial tumour of ovary of borderline malignancy · epithelial tumour of the ovary of borderline malignancy · low malignant potential ovarian tumor (+10 more)

Disease family

This is a subtype of ovarian epithelial tumor. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › epithelial neoplasm › ovarian epithelial tumor › borderline epithelial tumor of ovary

Related subtypes (10): ovarian Brenner tumor, ovarian squamous cell neoplasm, ovarian mucinous neoplasm, ovarian seromucinous tumor, ovarian papillary tumor, ovarian mucinous adenofibroma, ovarian adenoma benign, malignant epithelial tumor of ovary, ovarian clear cell tumor, ovarian serous tumor

Subtypes (1): borderline ovarian serous tumor

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 6.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	2
PHASE1	2
Not specified	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00301756	PHASE2	COMPLETED	Belinostat in Treating Patients With Advanced Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer or Ovarian Low Malignant Potential Tumors
NCT00551070	PHASE2	COMPLETED	Selumetinib Sulfate in Treating Woman With Recurrent Low-Grade Ovarian Cancer or Peritoneum Cancer
NCT00031681	PHASE1	COMPLETED	7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)
NCT02520115	PHASE1	COMPLETED	Folate Receptor in Diagnosing Ovarian Cancer Using Serum Samples From Patients With Newly Diagnosed Pelvic Mass or Previously Diagnosed Ovarian Cancer
NCT00897442	Not specified	COMPLETED	Collecting Tumor Samples From Patients With Gynecological Tumors
NCT03742388	Not specified	UNKNOWN	A Genomic Analysis of Evolution of Epithelia Ovarian Tumors

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
SELUMETINIB	4	2
BELINOSTAT	4	1
UCN-01	2	1
CHEMBL4463209	0	1
CHEMBL1236539	0	1