Bowel dysfunction
disease diseaseOn this page
Also known as disease of lower digestive tractlower digestive tract disease
Summary
Bowel dysfunction (MONDO:0004880) is a disease and 41 clinical trials. Top therapeutic interventions include alvimopan, neostigmine, and sugammadex. A subtype of intestinal disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 41
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | bowel dysfunction |
| Mondo ID | MONDO:0004880 |
| DOID | DOID:9779 |
| SNOMED CT | 235594008 |
| UMLS | C2004461 |
| MedGen | 384468 |
| Is cancer (heuristic) | no |
Also known as: disease of lower digestive tract · lower digestive tract disease
Disease family
This is a subtype of intestinal disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › bowel dysfunction
Related subtypes (57): intestinal atresia, steatorrhea, angiodysplasia of intestine, endometriosis of intestine, hypertrophic pyloric stenosis, mucocele of appendix, gastroenteritis, diverticulitis, intestinal obstruction, postgastrectomy syndrome, chronic intestinal vascular insufficiency, irritable bowel syndrome, Whipple disease, inflammatory bowel disease, intestinal polyp, necrotizing enterocolitis, intestinal perforation, neurogenic bowel, pneumatosis cystoides intestinalis, volvulus of midgut, abetalipoproteinemia, aplasia cutis congenita-intestinal lymphangiectasia syndrome, trichohepatoenteric syndrome, protein-losing enteropathy, chronic diarrhea with villous atrophy, Satoyoshi syndrome, glucose-galactose malabsorption, congenital diarrhea 7 with exudative enteropathy, chronic atrial and intestinal dysrhythmia, congenital enterocyte heparan sulfate deficiency, short bowel syndrome, intractable diarrhea-choanal atresia-eye anomalies syndrome, solitary rectal ulcer syndrome, NK-cell enteropathy, chronic intestinal failure, intestinal lymphangiectasia, refractory celiac disease, eosinophilic gastrointestinal disease, cryptogenic multifocal ulcerous stenosing enteritis, chronic enteropathy associated with SLCO2A1 gene, cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder, malakoplakia, malabsorption syndrome, ischemic bowel disorder, intestinal neoplasm, intestinal motility disease, 4-hydroxyphenylacetic aciduria, parasitic intestinal disorder, Aeromonas hydrophila intestinal disease, large intestine disorder, small intestine disorder, primary desmosis coli, isolated mesenteric vein thrombosis, collagenous sprue, visceral leiomyopathy, African degenerative, intestinal dysmotility syndrome, intestinal fistula
Subtypes (1): constipation disorder
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 41.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 31 |
| PHASE3 | 3 |
| PHASE2 | 3 |
| PHASE4 | 2 |
| PHASE1/PHASE2 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01312259 | PHASE4 | UNKNOWN | Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome |
| NCT04546672 | PHASE4 | COMPLETED | Sugammadex To IMprove Bowel Function |
| NCT00241722 | PHASE3 | COMPLETED | Long-Term Safety Evaluation Of Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain |
| NCT00256932 | PHASE3 | COMPLETED | Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain |
| NCT00259922 | PHASE3 | COMPLETED | Alvimopan For The Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain |
| NCT00101998 | PHASE2 | COMPLETED | Study Of Alvimopan Drug For Treatment Of Constipation Due To Prescription Pain Medication |
| NCT00135577 | PHASE2 | COMPLETED | Study 767905/008 Extension Study: Alvimopan for Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain Subjects |
| NCT01367574 | PHASE2 | COMPLETED | Methylnaltrexone in Patients With Opioid-Induced Bowel Dysfunction |
| NCT02838849 | PHASE1/PHASE2 | COMPLETED | Fiber and Water Improve Bowel Habit in Humans |
| NCT04507945 | PHASE1/PHASE2 | UNKNOWN | Stablishment of Prevention and Treatment System for Intestinal Dysfunction |
| NCT04893876 | Not specified | NOT_YET_RECRUITING | The OPERa Study: Evaluating QoL After Rectal Cancer Surgery |
| NCT05380856 | Not specified | RECRUITING | Sacral Neuromodulation for Neurogenic Lower Urinary Tract, Bowel and Sexual Dysfunction |
| NCT06288464 | Not specified | RECRUITING | Enteral Feeding of Fibre to Improve Microbiota |
| NCT06311110 | Not specified | RECRUITING | Impaired Toilet Training, LUTS and Bowel Dysfunction in Children With DCD |
| NCT06315179 | Not specified | RECRUITING | Seattle Spatial Transcriptomic Research in Inflammatory Bowel Disease Evaluation (STRIDE) |
| NCT06524362 | Not specified | NOT_YET_RECRUITING | Effect of Pelvic Rehabilitation After Low Anterior Resection for Cancer Rectum. - A Randomised Controlled Trial |
| NCT06587841 | Not specified | RECRUITING | Noninvasive Spinal Cord Stimulation for Early SCI |
| NCT01618292 | Not specified | COMPLETED | Cohort Study of Bowel Function Following Robotic-assisted Laparoscopic Sacrocolpopexy |
| NCT02013505 | Not specified | TERMINATED | A Validated Educational Video Intervention Improves the Quality of Bowel Preparation for Colonoscopy |
| NCT03009747 | Not specified | UNKNOWN | A Prospective Multi-Center Research on Bowel Dysfunction After Sphincter Preservative Surgery |
| NCT03028636 | Not specified | COMPLETED | LIBERATE - PRO: Eclipse™ System Registry |
| NCT03761147 | Not specified | COMPLETED | Gastrointestinal Activation Post-elective CS (Cesarean Section) :A Comparison of Paula Method to Standard Care |
| NCT03779256 | Not specified | COMPLETED | Bowel ENDOmetriosis; Evaluation of Diagnostics and Quality of Life |
| NCT03841513 | Not specified | COMPLETED | Minimally Invasive Burch Colposuspension to Reduce Occult Stress Incontinence |
| NCT03885999 | Not specified | COMPLETED | Studies in Patients With Low Anterior Resection Syndrome (LARS) |
| NCT04134104 | Not specified | COMPLETED | Incidence of The Bowel, Bladder, and Sexual Dysfunction Following Surgery for Colorectal Malignancy |
| NCT04205058 | Not specified | UNKNOWN | Coffee After Pancreatic Surgery |
| NCT04299867 | Not specified | COMPLETED | Perioperative Tissue Penetration of Antimicrobials in Infants |
| NCT04319991 | Not specified | UNKNOWN | The Clinical Evaluation of Probiotics Product in Patients With Various Functional Bowel Disorders and Helicobacter Pylori Infection |
| NCT04490642 | Not specified | UNKNOWN | Linguistic Validation of the Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ) for 5-12 Years Old in Korean |
| NCT04579731 | Not specified | COMPLETED | Development of Fecal Scoring for the Management of Fecal Impaction With Regards to Lower Urinary Tract Dysfunction |
| NCT04914975 | Not specified | COMPLETED | The Effect of NMES on Bowel Management in People With Chronic SCI |
| NCT05239481 | Not specified | UNKNOWN | Design and Clinical Application of Colonoscopy Position Identification Sheet |
| NCT05351138 | Not specified | COMPLETED | Comparison of Transcutaneous Electrical Nerve Stimulation and Manual Therapy in Children With Cerebral Palsy |
| NCT05644912 | Not specified | COMPLETED | Exploratory Investigation on a Novel Catheter |
| NCT05655845 | Not specified | UNKNOWN | Risk Factors for Bowel Dysfunction at Preschool and Early Childhood Age in Children With Hirschsprung Disease |
| NCT05716230 | Not specified | UNKNOWN | Bowel Function and Associated Risk Factors for Bowel Dysfunciton in Patients With Anorectal Malformation |
| NCT05880446 | Not specified | COMPLETED | PROstate CAncer Radiotherapy - Bowel Quality of Life (PROCAR-BQ) |
| NCT06252714 | Not specified | COMPLETED | Impact of Defecation Posture on Ease of Bowel Movements in Patients With a Rectocele |
| NCT06377280 | Not specified | COMPLETED | En Evaluation of Navina Mini, a New Low-volume Transanal Irrigation Device. |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ALVIMOPAN | 4 | 5 |
| NEOSTIGMINE | 4 | 4 |
| SUGAMMADEX | 4 | 3 |
| LACTITOL | 4 | 1 |
| CHEMBL5412674 | 0 | 1 |
Related Atlas pages
- Drugs: Alvimopan, Neostigmine, Sugammadex, Lactitol