Brain stem glioma
diseaseOn this page
Also known as brain stem neuroglial neoplasmbrain stem neuroglial tumorbrain stem neuroglial tumourbrainstem gliomabrainstem malignant gliomabrainstem neuroglial neoplasmbrainstem neuroglial tumorbrainstem neuroglial tumourdiffuse brainstem gliomaglioma of brain stemglioma of brainstemglioma of the brain stemglioma of the brainstemmalignant glioma of brainstem
Summary
Brain stem glioma (MONDO:0002911) is a cancer (an umbrella term covering 5 Mondo subtypes) and 28 clinical trials. Top therapeutic interventions include bevacizumab, mebendazole, and temozolomide. A subtype of brainstem cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 5 Mondo subtypes
- Clinical trials: 28
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | brain stem glioma |
| Mondo ID | MONDO:0002911 |
| EFO | EFO:1000142 |
| DOID | DOID:4202 |
| NCIT | C8501 |
| SNOMED CT | 444545003 |
| UMLS | C0677865 |
| MedGen | 195650 |
| GARD | 0023297 |
| Anatomy (UBERON) | UBERON:0002298 |
| Is cancer (heuristic) | yes |
Also known as: brain stem glioma · brain stem neuroglial neoplasm · brain stem neuroglial tumor · brain stem neuroglial tumour · brainstem glioma · brainstem malignant glioma · brainstem neuroglial neoplasm · brainstem neuroglial tumor · brainstem neuroglial tumour · diffuse brainstem glioma · glioma of brain stem · glioma of brainstem · glioma of the brain stem · glioma of the brainstem · malignant glioma of brainstem
Disease family
An umbrella term covering 5 Mondo subtypes.
Classification path: disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › nervous system cancer › central nervous system cancer › brain cancer › infratentorial cancer › brainstem cancer › brain stem glioma
Related subtypes (1): childhood brain stem neoplasm
Subtypes (5): adult brainstem glioma, brain stem astrocytic neoplasm, brain stem ependymoma, childhood brain stem glioma, brain stem glioblastoma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 28.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE1 | 9 |
| PHASE2 | 6 |
| Not specified | 6 |
| PHASE1/PHASE2 | 3 |
| PHASE3 | 2 |
| PHASE2/PHASE3 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02864888 | PHASE3 | NOT_YET_RECRUITING | Effect of Antineoplaston Therapy on the QT/QTc Interval In Subjects With Diffuse, Intrinsic, Brainstem Glioma |
| NCT02887040 | PHASE3 | NOT_YET_RECRUITING | Study of Antineoplaston Therapy + Radiation vs. Radiation Only in Diffuse, Intrinsic, Brainstem Glioma |
| NCT01236560 | PHASE2/PHASE3 | COMPLETED | Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade Glioma |
| NCT00840047 | PHASE2 | ACTIVE_NOT_RECRUITING | Methionine PET/CT Studies In Patients With Cancer |
| NCT00003459 | PHASE2 | COMPLETED | Antineoplaston Therapy in Treating Patients With Brain Stem Glioma |
| NCT00879437 | PHASE2 | COMPLETED | Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma |
| NCT01095094 | PHASE2 | TERMINATED | Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma |
| NCT01118377 | PHASE2 | COMPLETED | A Study of Capecitabine (Xeloda®) and Concomitant Radiation Therapy in Children With Newly Diagnosed Brainstem Gliomas |
| NCT01514201 | PHASE1/PHASE2 | COMPLETED | Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas |
| NCT01756989 | PHASE2 | COMPLETED | ANGIOCOMB Antiangiogenic Therapy for Pediatric Patients With Diffuse Brain Stem and Thalamic Tumors |
| NCT01837862 | PHASE1/PHASE2 | COMPLETED | A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas |
| NCT01884740 | PHASE1/PHASE2 | TERMINATED | Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 |
| NCT04196413 | PHASE1 | RECRUITING | GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas (DIPG) & Spinal Diffuse Midline Glioma(DMG) |
| NCT00576641 | PHASE1 | COMPLETED | Immunotherapy for Patients With Brain Stem Glioma and Glioblastoma |
| NCT01082926 | PHASE1 | COMPLETED | Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 |
| NCT01316809 | PHASE1 | COMPLETED | AZD8055 for Adults With Recurrent Gliomas |
| NCT01502917 | PHASE1 | COMPLETED | Convection-Enhanced Delivery of 124I-Omburtamab for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy |
| NCT03178032 | PHASE1 | COMPLETED | Oncolytic Adenovirus, DNX-2401, for Naive Diffuse Intrinsic Pontine Gliomas |
| NCT03355794 | PHASE1 | COMPLETED | A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) |
| NCT03392545 | PHASE1 | UNKNOWN | Combination of Immunization and Radiotherapy for Malignant Gliomas (InSituVac1) |
| NCT03396575 | PHASE1 | TERMINATED | Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I) |
| NCT02976441 | EARLY_PHASE1 | WITHDRAWN | Autologous Stem Cell Collection and Reinfusion in Newly Diagnosed High Grade Gliomas |
| NCT01106794 | Not specified | RECRUITING | Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma |
| NCT07608003 | Not specified | RECRUITING | Multicenter Prospective Study on MRI AI Model for Midline Glioma Subtyping and Prognosis: |
| NCT01117155 | Not specified | WITHDRAWN | A Pilot Study Evaluating 18F-L-Thymidine (FLT) PET Imaging in Children With Gliomas |
| NCT03666507 | Not specified | COMPLETED | Vegetative Monitoring During Brainstem-associated Surgery |
| NCT05934630 | Not specified | TERMINATED | Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors |
| NCT06439849 | Not specified | NO_LONGER_AVAILABLE | Single Patient Compassionate Use / Expanded Access L-S-Gboxin (Lyophilized Form of S-Gboxin) for the Treatment of Diffuse Midline Glioma |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| BEVACIZUMAB | 4 | 4 |
| MEBENDAZOLE | 4 | 1 |
| TEMOZOLOMIDE | 4 | 1 |
| VALPROIC ACID | 4 | 1 |
| VORINOSTAT | 4 | 1 |
| ANTINEOPLASTON A10 | 3 | 2 |
| VELIPARIB | 3 | 2 |
| METHIONINE | 3 | 1 |
| TASADENOTUREV | 2 | 1 |
| AZD-8055 | 1 | 1 |
| CHEMBL4228794 | 0 | 1 |
| CHEMBL4248195 | 0 | 1 |
| CHEMBL1234268 | 0 | 1 |
| CHEMBL4787699 | 0 | 1 |
| RACEMETHIONINE | -1 | 1 |