Brainstem neoplasm
diseaseOn this page
Also known as Brain stem neoplasmbrain stem tumorbrain stem tumourbrainstem neoplasm (disease)brainstem tumorbrainstem tumourneoplasm of brain stemneoplasm of brainstemneoplasm of the brain stemneoplasm of the brainstemtumor of brain stemtumor of brainstemtumor of the brain stemtumor of the brainstemtumour of brain stemtumour of brainstemtumour of the brain stemtumour of the brainstem
Summary
Brainstem neoplasm (MONDO:0021228) is a cancer and 8 clinical trials. Top therapeutic interventions include imetelstat sodium, temsirolimus, and entinostat. A subtype of brain neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 8
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | brainstem neoplasm |
| Mondo ID | MONDO:0021228 |
| EFO | EFO:1001767 |
| Orphanet | 36414 |
| NCIT | C4869 |
| UMLS | C0677866 |
| MedGen | 146207 |
| Anatomy (UBERON) | UBERON:0002298 |
| Is cancer (heuristic) | yes |
Also known as: Brain stem neoplasm · brain stem tumor · brain stem tumour · brainstem neoplasm (disease) · brainstem tumor · brainstem tumour · neoplasm of brain stem · neoplasm of brainstem · neoplasm of the brain stem · neoplasm of the brainstem · tumor of brain stem · tumor of brainstem · tumor of the brain stem · tumor of the brainstem · tumour of brain stem · tumour of brainstem · tumour of the brain stem · tumour of the brainstem
Disease family
This is a subtype of brain neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › brain disorder › brain neoplasm › brainstem neoplasm
Related subtypes (16): brain cancer, cerebellopontine angle tumor, olfactory nerve neoplasm, cerebellar neoplasm, childhood brain meningioma, olfactory groove meningioma, dysembryoplastic neuroepithelial tumor, hypothalamic neoplasm, optic pathway glioma, choroid plexus neoplasm, pineal body neoplasm, neoplasm of cerebral hemisphere, benign neoplasm of brain, primary brain neoplasm, optic tract meningioma, infratentorial neoplasm
Subtypes (4): brain stem medulloblastoma, brainstem cancer, benign neoplasm of brain stem, adult brain stem neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Carboplatin, Thalidomide.
Clinical trials & evidence
Clinical trials
Clinical trials: 8.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE1 | 4 |
| Not specified | 3 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01836549 | PHASE2 | TERMINATED | Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors |
| NCT01058850 | PHASE1 | TERMINATED | Phase I Rindopepimut After Conventional Radiation in Children w/ Diffuse Intrinsic Pontine Gliomas |
| NCT01182883 | PHASE1 | WITHDRAWN | A Phase I Study of IMC-A12 in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors |
| NCT01975116 | PHASE1 | COMPLETED | p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors |
| NCT02780804 | PHASE1 | COMPLETED | Entinostat in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors |
| NCT06516471 | Not specified | NOT_YET_RECRUITING | The Evolution of Neuroendoscopy Guided by Head-mounted Mixed Reality Technique Navigation System in Neurosurgery |
| NCT03666507 | Not specified | COMPLETED | Vegetative Monitoring During Brainstem-associated Surgery |
| NCT04028479 | Not specified | COMPLETED | The Registry of Oncology Outcomes Associated With Testing and Treatment |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| IMETELSTAT SODIUM | 4 | 1 |
| TEMSIROLIMUS | 4 | 1 |
| ENTINOSTAT | 3 | 1 |
| RINDOPEPIMUT | 3 | 1 |
| CIXUTUMUMAB | 2 | 1 |
Related Atlas pages
- Drugs: Imetelstat, Temsirolimus, Entinostat, Rindopepimut