BRCA1-related cancer predisposition

Summary

BRCA1-related cancer predisposition (MONDO:0700268) is a cancer caused by BRCA1 (GenCC Definitive), with 1 cohort gene (1 CIViC-evidence somatic driver; 441 ClinVar predisposition records).

At a glance

• Classification: Cancer
• Causal gene: BRCA1 (GenCC Definitive)
• Cohort genes: 1
• ClinVar variants: 441

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	BRCA1-related cancer predisposition
Mondo ID	MONDO:0700268
GARD	0026408
Is cancer (heuristic)	yes

Data availability: 441 ClinVar variants · 75 ClinGen variant curations · 1 GenCC gene-disease record.

Disease family

An umbrella term covering 2 Mondo subtypes.

Classification path: disease › human disease › disease by etiologic mechanism › disease of genetic or genomic mechanism › hereditary disease › hereditary neoplastic syndrome › BRCA1-related cancer predisposition

Related subtypes (116): mosaic variegated aneuploidy syndrome, tuberous sclerosis, hereditary breast ovarian cancer syndrome, hereditary multiple osteochondromas, nevoid basal cell carcinoma syndrome, leukemia, chronic lymphocytic, susceptibility to, 2, blue rubber bleb nevus, cherubism, Beckwith-Wiedemann syndrome, multiple self-healing squamous epithelioma, erythroleukemia, familial, susceptibility to, goiter, multinodular 1, with or without Sertoli-Leydig cell tumors, hyperparathyroidism 2 with jaw tumors, Kaposi sarcoma, susceptibility to, hereditary leiomyomatosis and renal cell cancer, susceptibility to uveal melanoma, melanoma and neural system tumor syndrome, nasopharyngeal carcinoma, susceptibility to, 2, WAGR syndrome, neuroblastoma, susceptibility to, 1, Rothmund-Thomson syndrome, mismatch repair cancer syndrome 1, Wiskott-Aldrich syndrome, N syndrome, hereditary thrombocytopenia and hematologic cancer predisposition syndrome, prostate cancer/brain cancer susceptibility, Brooke-Spiegler syndrome, pancreatic cancer, susceptibility to, 1, Carney-Stratakis syndrome, nasopharyngeal carcinoma, susceptibility to, 1, ovarian cancer, susceptibility to, 1, colorectal cancer, susceptibility to, 1, lung cancer susceptibility 1, leukemia, chronic lymphocytic, susceptibility to, 1, Kostmann syndrome, colorectal cancer, susceptibility to, 2, colorectal cancer, susceptibility to, 3, colorectal cancer, susceptibility to, 5, colorectal cancer, susceptibility to, 6, colorectal cancer, susceptibility to, 7, leukemia, chronic lymphocytic, susceptibility to, 3, leukemia, chronic lymphocytic, susceptibility to, 4, leukemia, chronic lymphocytic, susceptibility to, 5, lung cancer susceptibility 3, colorectal cancer, susceptibility to, 8, colorectal cancer, susceptibility to, 9, colorectal cancer, susceptibility to, 10, colorectal cancer, susceptibility to, 11, lung cancer susceptibility 4, neuroblastoma, susceptibility to, 3, neuroblastoma, susceptibility to, 4, neuroblastoma, susceptibility to, 5, neuroblastoma, susceptibility to, 6, leukemia, acute lymphocytic, susceptibility to, 1, leukemia, acute lymphocytic, susceptibility to, 2, lung cancer susceptibility 5, BAP1-related tumor predisposition syndrome, familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome, Maffucci syndrome, basal cell carcinoma, susceptibility to, 7, colorectal cancer, susceptibility to, 12, leukemia, acute lymphoblastic, susceptibility to, 3, cholangiocarcinoma, susceptibility to, progeroid features-hepatocellular carcinoma predisposition syndrome, neuroblastoma, susceptibility to, 7, DDX41-related hematologic malignancy predisposition syndrome, nasopharyngeal carcinoma, susceptibility to, 3, familial isolated hyperparathyroidism, intestinal polyposis syndrome, dyskeratosis congenita, familial rhabdoid tumor, multiple endocrine neoplasia, hereditary pheochromocytoma-paraganglioma, PTEN hamartoma tumor syndrome, familial multiple fibrofolliculoma, hereditary retinoblastoma, familial atypical multiple mole melanoma syndrome, hereditary nonpolyposis colon cancer, Li-Fraumeni syndrome, Cobb syndrome, neurofibromatosis, susceptibility to familial cutaneous melanoma, pancreatic cancer, susceptibility to, 5, leukemia, acute myeloid, susceptibility to, diffuse gastric and lobular breast cancer syndrome with or without cleft lip and/or palate, glioma susceptibility, hemangioma, capillary infantile, susceptibility to, CDH1-related diffuse gastric and lobular breast cancer syndrome, NTHL1-deficiency tumor predisposition syndrome, SAMD9-related spectrum and myeloid neoplasm risk, neuroblastoma, susceptibility to, 2, BARD1-related cancer predisposition, BRCA2-related cancer predisposition, ATM-related cancer predisposition, CHEK2-related cancer predisposition, PALB2-related cancer predisposition, RAD51C-related cancer predisposition, RAD51D-related cancer predisposition, Li-fraumeni-like syndrome, breast cancer, familial, susceptibility to, 1, breast cancer, familial, susceptibility to, 2, breast cancer, familial, susceptibility to, 3, colorectal cancer, susceptibility to, 4, colorectal cancer, susceptibility to, on chromosome 15, ovarian cancer, familial, susceptibility to, 1, ovarian cancer, familial, susceptibility to, 2, ovarian cancer, familial, susceptibility to, 3, inherited hematologic cancer-predisposing syndrome, mosaic neurofibromatosis/schwannomatosis, tumor predisposition syndrome 2, prostate cancer, hereditary, X-linked 3, follicular lymphoma, susceptibility to, GPR161-related medulloblastoma predisposition, SAMD9L-related spectrum and myeloid neoplasm risk, HAVCR2-related cancer predisposition, EGLN1-related erythrocytosis and pheochromocytoma/paraganglioma predisposition

Subtypes (2): breast-ovarian cancer, familial, susceptibility to, 1, pancreatic cancer, susceptibility to, 4

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

ClinVar germline variants

441 retrieved; paginated sample, class counts are floors:

155 conflicting classifications of pathogenicity, 77 pathogenic, 59 uncertain significance, 58 likely benign, 49 benign, 33 likely pathogenic, 6 benign/likely benign, 4 pathogenic/likely pathogenic

ClinVar	Variant (HGVS)	Gene	Classification	Review
125465	NM_007294.4(BRCA1):c.882del (p.Asp295fs)	BRCA1	Pathogenic	reviewed by expert panel
125519	NM_007294.4(BRCA1):c.80+4A>T	BRCA1	Pathogenic	reviewed by expert panel
125725	NM_007294.4(BRCA1):c.4676-1G>A	BRCA1	Pathogenic	reviewed by expert panel
125777	NM_007294.4(BRCA1):c.5152+6T>C	BRCA1	Pathogenic	reviewed by expert panel
17661	NM_007294.4(BRCA1):c.181T>G (p.Cys61Gly)	BRCA1	Pathogenic	reviewed by expert panel
17662	NM_007294.4(BRCA1):c.68_69del (p.Glu23fs)	BRCA1	Pathogenic	reviewed by expert panel
17665	NM_007294.4(BRCA1):c.1175_1214del (p.Leu392fs)	BRCA1	Pathogenic	reviewed by expert panel
17671	NM_007294.4(BRCA1):c.3607C>T (p.Arg1203Ter)	BRCA1	Pathogenic	reviewed by expert panel
17672	NM_007294.4(BRCA1):c.3748G>T (p.Glu1250Ter)	BRCA1	Pathogenic	reviewed by expert panel
17674	NM_007294.4(BRCA1):c.4065_4068del (p.Asn1355fs)	BRCA1	Pathogenic	reviewed by expert panel
17675	NM_007294.4(BRCA1):c.4327C>T (p.Arg1443Ter)	BRCA1	Pathogenic	reviewed by expert panel
17677	NM_007294.4(BRCA1):c.5266dup (p.Gln1756fs)	BRCA1	Pathogenic	reviewed by expert panel
17684	NM_007294.4(BRCA1):c.3481_3491del (p.Glu1161fs)	BRCA1	Pathogenic	reviewed by expert panel
17693	NM_007294.4(BRCA1):c.211A>G (p.Arg71Gly)	BRCA1	Pathogenic	reviewed by expert panel
17694	NM_007294.4(BRCA1):c.5324T>G (p.Met1775Arg)	BRCA1	Pathogenic	reviewed by expert panel
230548	NM_007294.4(BRCA1):c.3294del (p.Pro1099fs)	BRCA1	Pathogenic	reviewed by expert panel
233241	NM_007294.4(BRCA1):c.2101A>T (p.Lys701Ter)	BRCA1	Pathogenic	reviewed by expert panel
246362	NM_007294.4(BRCA1):c.442-22_442-13del	BRCA1	Pathogenic	reviewed by expert panel
267530	NM_007294.4(BRCA1):c.4186-1787_4358-1668dup	BRCA1	Pathogenic	reviewed by expert panel
267601	NM_007294.4(BRCA1):c.5333-36_5406+400del	BRCA1	Pathogenic	reviewed by expert panel
3226100	NM_007294.4(BRCA1):c.137_141delinsAATTTATAGATTT (p.Phe46_Cys47delinsTer)	BRCA1	Pathogenic	criteria provided, multiple submitters, no conflicts
3386218	NM_007294.4(BRCA1):c.442-814_2022del	BRCA1	Pathogenic	criteria provided, single submitter
37404	NM_007294.4(BRCA1):c.135-1G>T	BRCA1	Pathogenic	reviewed by expert panel
37426	NM_007294.4(BRCA1):c.1687C>T (p.Gln563Ter)	BRCA1	Pathogenic	reviewed by expert panel
37435	NM_007294.4(BRCA1):c.1953_1956del (p.Lys653fs)	BRCA1	Pathogenic	reviewed by expert panel
37438	NM_007294.4(BRCA1):c.1961del (p.Lys654fs)	BRCA1	Pathogenic	reviewed by expert panel
37449	NM_007294.4(BRCA1):c.213-11T>G	BRCA1	Pathogenic	criteria provided, multiple submitters, no conflicts
37451	NM_007294.4(BRCA1):c.2138C>G (p.Ser713Ter)	BRCA1	Pathogenic	reviewed by expert panel
37466	NM_007294.4(BRCA1):c.2411_2412del (p.Gln804fs)	BRCA1	Pathogenic	reviewed by expert panel
37469	NM_007294.4(BRCA1):c.2433del (p.Lys812fs)	BRCA1	Pathogenic	reviewed by expert panel

Genes & proteins

Mendelian disease overlap and somatic drivers

GenCC: 11 · Orphanet: 9 · OMIM-shared: 0 · Dual-evidence (GWAS+Mendelian): 0

Somatic driver evidence (intOGen + CIViC, cohort fanout)

Gene	intOGen role	Cancer types	CIViC
BRCA1	LoF	BLCA,BRCA,MEL,OVT	CIViC #6

GenCC gene–disease validity (cohort genes)

the Disease column is the GenCC-asserted condition — a cohort gene’s strongest validity may be for a related predisposition syndrome.

Gene	Classification	Inheritance	Disease	Records
BRCA1	Definitive	Autosomal dominant	BRCA1-related cancer predisposition	11

Orphanet rare-disease linkage (cohort genes)

Gene	Orphanet ID	Rare disease
BRCA1	Orphanet:1331	Familial prostate cancer
BRCA1	Orphanet:1333	Familial pancreatic carcinoma
BRCA1	Orphanet:145	Hereditary breast and/or ovarian cancer syndrome
BRCA1	Orphanet:168829	Primary peritoneal carcinoma
BRCA1	Orphanet:227535	Hereditary breast cancer
BRCA1	Orphanet:667662	Breast implant-associated anaplastic large cell lymphoma
BRCA1	Orphanet:694963	Inflammatory breast cancer
BRCA1	Orphanet:70567	Cholangiocarcinoma
BRCA1	Orphanet:84	Fanconi anemia

Cohort genes → proteins

1 cohort genes, 1 distinct canonical proteins.

Evidence partition

Subset	Genes
multi_evidence	1

Cohort genes (full)

Symbol	HGNC	Ensembl	UniProt	Name	Evidence
BRCA1	HGNC:1100	ENSG00000012048	P38398	Breast cancer type 1 susceptibility protein	gencc,clinvar

Cohort function summary

Lead sentence per gene, UniProt-curated.

Symbol	Protein name	Function (lead sentence)
BRCA1	Breast cancer type 1 susceptibility protein	E3 ubiquitin-protein ligase that specifically mediates the formation of ‘Lys-6’-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage.

Protein-family classification

Druggable: 0 · Difficult: 1 · Unknown: 0 · Druggable fraction: 0.0

Family distribution

Cohort families vs a genome-wide background (hypergeometric, BH-FDR; fold = observed/expected). Counts kept; sorted by enrichment, so the catch-all Other/Unknown bucket no longer leads.

Family	Genes	Fold	FDR
Transcription factor	1	8.3×	0.121

Per-gene assignment

Symbol	Family	Druggable?	EC	InterPro (top 3)
BRCA1	Transcription factor	no	2.3.2.27	BRCT_dom, Znf_RING, BRCA1

Expression context

Cohort genes with no expression data: 0.

1 cohort gene are a single-cell marker in ≥1 SCXA experiment.

Breadth distribution (Bgee present_calls)

Bucket	Genes
narrow (1-5 tissues)	0
moderate (6-20)	0
broad (>20)	1
unknown	0

Top tissues across cohort

Tissue	Cohort genes
male germ line stem cell (sensu Vertebrata) in testis	1
primordial germ cell in gonad	1
ventricular zone	1

Per-gene tissue summary (top 30)

Symbol	Bgee breadth	FANTOM5 breadth	SCXA	Top tissues
BRCA1	208	ubiquitous	marker	ventricular zone, male germ line stem cell (sensu Vertebrata) in testis, primordial germ cell in gonad

Protein interactions among cohort

Intra-cohort edges: 0.

Hub genes (top 10 by interactor count)

Symbol	Interactor count
BRCA1	9,064

Structural data

PDB: 1 · AlphaFold-only: 0 · No structure: 0

Cohort genes with PDB structures (top 30)

Symbol	UniProt	PDB entries
BRCA1	P38398	33

Function

Pathway analysis

Distinct Reactome pathways touched by cohort: 59. Enrichment computed across 1 evidence-associated genes (1 with Reactome annotation).

Pathways by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 1 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

Pathway	Cohort genes	Fold	FDR	Sample cohort genes
Defective DNA double strand break response due to BRCA1 loss of function	1	5710.0×	0.005	BRCA1
Defective DNA double strand break response due to BARD1 loss of function	1	5710.0×	0.005	BRCA1
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	1	1631.4×	0.009	BRCA1
Defective homologous recombination repair (HRR) due to PALB2 loss of function	1	951.7×	0.009	BRCA1
Diseases of DNA Double-Strand Break Repair	1	815.7×	0.009	BRCA1
Defective homologous recombination repair (HRR) due to BRCA2 loss of function	1	815.7×	0.009	BRCA1
Resolution of D-Loop Structures	1	634.4×	0.009	BRCA1
Diseases of DNA repair	1	571.0×	0.009	BRCA1
DNA Double Strand Break Response	1	475.8×	0.009	BRCA1
Impaired BRCA2 binding to PALB2	1	456.8×	0.009	BRCA1
Defective homologous recombination repair (HRR) due to BRCA1 loss of function	1	423.0×	0.009	BRCA1
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	1	423.0×	0.009	BRCA1
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	1	423.0×	0.009	BRCA1
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	1	393.8×	0.009	BRCA1
Homologous DNA Pairing and Strand Exchange	1	380.7×	0.009	BRCA1
Homology Directed Repair	1	308.6×	0.009	BRCA1
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	1	308.6×	0.009	BRCA1
Impaired BRCA2 binding to RAD51	1	308.6×	0.009	BRCA1
Metalloprotease DUBs	1	300.5×	0.009	BRCA1
Resolution of D-loop Structures through Holliday Junction Intermediates	1	300.5×	0.009	BRCA1
HDR through Single Strand Annealing (SSA)	1	292.8×	0.009	BRCA1
Transcriptional Regulation by E2F6	1	292.8×	0.009	BRCA1
Meiosis	1	285.5×	0.009	BRCA1
Presynaptic phase of homologous DNA pairing and strand exchange	1	271.9×	0.009	BRCA1
DNA Double-Strand Break Repair	1	248.3×	0.010	BRCA1
Reproduction	1	190.3×	0.011	BRCA1
HDR through Homologous Recombination (HRR)	1	190.3×	0.011	BRCA1
TP53 Regulates Transcription of DNA Repair Genes	1	181.3×	0.011	BRCA1
MITF-M-dependent gene expression	1	181.3×	0.011	BRCA1
SUMO E3 ligases SUMOylate target proteins	1	178.4×	0.011	BRCA1

GO biological processes by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 1 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

GO term	Cohort genes	Fold	FDR	Sample cohort genes
cellular response to indole-3-methanol	1	3370.4×	0.004	BRCA1
chordate embryonic development	1	2808.7×	0.004	BRCA1
negative regulation of centriole replication	1	2407.4×	0.004	BRCA1
DNA strand resection involved in replication fork processing	1	2106.5×	0.004	BRCA1
DNA damage tolerance	1	1685.2×	0.004	BRCA1
homologous recombination	1	1404.3×	0.004	BRCA1
negative regulation of intracellular estrogen receptor signaling pathway	1	1123.5×	0.004	BRCA1
regulation of DNA damage checkpoint	1	1123.5×	0.004	BRCA1
negative regulation of gene expression via chromosomal CpG island methylation	1	1053.2×	0.004	BRCA1
protein K6-linked ubiquitination	1	991.3×	0.004	BRCA1
random inactivation of X chromosome	1	936.2×	0.004	BRCA1
negative regulation of reactive oxygen species metabolic process	1	936.2×	0.004	BRCA1
negative regulation of fatty acid biosynthetic process	1	887.0×	0.004	BRCA1
mitotic G2/M transition checkpoint	1	802.5×	0.004	BRCA1
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	1	581.1×	0.005	BRCA1
positive regulation of vascular endothelial growth factor production	1	495.6×	0.005	BRCA1
mitotic G2 DNA damage checkpoint signaling	1	443.5×	0.005	BRCA1
response to ionizing radiation	1	411.0×	0.005	BRCA1
cellular response to ionizing radiation	1	411.0×	0.005	BRCA1
positive regulation of DNA repair	1	358.6×	0.006	BRCA1
fatty acid biosynthetic process	1	351.1×	0.006	BRCA1
centrosome cycle	1	337.0×	0.006	BRCA1
intrinsic apoptotic signaling pathway in response to DNA damage	1	324.1×	0.006	BRCA1
negative regulation of cell cycle	1	290.6×	0.006	BRCA1
regulation of DNA repair	1	276.3×	0.006	BRCA1
protein autoubiquitination	1	234.1×	0.007	BRCA1
double-strand break repair	1	203.0×	0.008	BRCA1
chromosome segregation	1	173.7×	0.009	BRCA1
cellular response to tumor necrosis factor	1	163.6×	0.009	BRCA1
double-strand break repair via homologous recombination	1	156.0×	0.009	BRCA1

Therapeutics

Drug target analysis

Approved (phase 4): 1 · Phase ≥3: 1 · Phased (≥1): 1 · Undrugged: 0

Druggability breadth: 1 of 1 evidence-associated genes (100%) have a ChEMBL target (buckets above are over the deeply-mined display cohort).

Genes with an approved drug

The molecule shown is one approved compound that hits the gene — not necessarily a drug of choice or one indicated for this disease.

Symbol	Example approved molecule
BRCA1	RIBOFLAVIN

Top cohort targets by molecule count

Symbol	Molecules	Max phase
BRCA1	12	4

Drugs targeting cohort genes (top 30)

Molecule	Max phase	Targets in cohort
RIBOFLAVIN	4	BRCA1
DAUNORUBICIN HYDROCHLORIDE	4	BRCA1
TOPOTECAN HYDROCHLORIDE	4	BRCA1
DAUNORUBICIN	4	BRCA1
DOXORUBICIN HYDROCHLORIDE	4	BRCA1
MESALAMINE	4	BRCA1
DIPYRIDAMOLE	4	BRCA1
CURCUMIN	3	BRCA1
SURAMIN	3	BRCA1
SURAMIN HEXASODIUM	3	BRCA1
SODIUM TANSHINONE IIA SULFONATE	2	BRCA1
HOMIDIUM BROMIDE	2	BRCA1

Bioactivity and enzyme data

Enzyme cohort genes (≥1 EC): 1.

Cohort genes with ChEMBL bioactivity (full, sorted by assay count)

Symbol	Assays	Type breakdown
BRCA1	13	Binding:9, Functional:4

Cohort enzymes (BRENDA EC)

Symbol	EC numbers	Names
BRCA1	2.3.2.27	RING-type E3 ubiquitin transferase

Pharmacogenomics

Cohort genes with a PharmGKB record: 1; with CPIC/DPWG dosing guidelines: 0.

No cohort gene has a CPIC/DPWG genotype-guided dosing guideline (PharmGKB).

Drug repurposing candidates

12 approved/phased drugs hit cohort targets but don’t yet appear in disease-level clinical trials. Target-inhibition rationale is strongest for cancer driver genes; a bioactivity hit is a screening signal, not a treatment claim.

Compound	Max phase	Cohort target (bioactivity)
RIBOFLAVIN	4	BRCA1
DAUNORUBICIN HYDROCHLORIDE	4	BRCA1
TOPOTECAN HYDROCHLORIDE	4	BRCA1
DAUNORUBICIN	4	BRCA1
DOXORUBICIN HYDROCHLORIDE	4	BRCA1
MESALAMINE	4	BRCA1
DIPYRIDAMOLE	4	BRCA1
CURCUMIN	3	BRCA1
SURAMIN	3	BRCA1
SURAMIN HEXASODIUM	3	BRCA1
SODIUM TANSHINONE IIA SULFONATE	2	BRCA1
HOMIDIUM BROMIDE	2	BRCA1

Druggability pyramid

Cohort genes binned by druggability tier (high → low):

Tier	Definition	Genes	Symbols
A	Approved (phase 4 drug)	1	BRCA1
B	Phased (≥1) drug, not yet approved	0
C	Druggable family + PDB, no drug	0
D	Druggable family + AlphaFold only, no drug	0
E	Difficult family or no structure, no drug	0

Undrugged target profiles

0 cohort genes are undrugged. Ranked by ‘starting-point quality’ (assay depth + drugged-partner adjacency).

Clinical trials & evidence

Clinical trials

Clinical trials: 0.