Breast fibroadenoma

Summary

Breast fibroadenoma (MONDO:0002056) is a disease and 22 clinical trials. Top therapeutic interventions include tamoxifen. A subtype of breast benign neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 22

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	breast fibroadenoma
Mondo ID	MONDO:0002056
MeSH	D018226
DOID	DOID:1618
ICD-11	143326763
NCIT	C3744
SNOMED CT	254847007
UMLS	C0178421
MedGen	64231
Is cancer (heuristic)	no

Also known as: breast fibroadenoma · FA · fibroadenoma · fibroadenoma of breast · fibroadenoma of the breast · fibroadenoma, benign · juvenile fibroadenoma (morphologic abnormality)

Disease family

This is a subtype of breast benign neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › benign neoplasm › thoracic benign neoplasm › breast benign neoplasm › breast fibroadenoma

Related subtypes (14): breast lipoma, breast cyst, benign eccrine breast spiradenoma, breast leiomyoma, breast adenoma, breast myofibroblastoma, benign breast adenomyoepithelioma, breast hemangioma, multiple fibroadenoma of the breast, benign breast phyllodes tumor, intraductal breast papilloma, benign neoplasm of male breast, diabetic mastopathy, lymphocytic mastitis

Subtypes (3): breast pericanalicular fibroadenoma, breast intracanalicular fibroadenoma, breast giant fibroadenoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 22.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	18
PHASE4	1
PHASE3	1
PHASE2	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00999921	PHASE4	COMPLETED	Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast Cancer
NCT00147108	PHASE3	TERMINATED	MR Guided Focused Ultrasound Surgery in the Treatment of Breast Fibroadenomas
NCT03715413	PHASE2	COMPLETED	Analgesic Efficacy of Pulsed Radiofrequency in Non-cyclic Mastalgia
NCT04341129	EARLY_PHASE1	COMPLETED	Abbreviated MRI Protocol: Initial Experience With Dotarem® (Gadoterate Meglumine)
NCT05219695	Not specified	RECRUITING	Medical Imaging and Thermal Treatment for Breast Tumors Using Harmonic Motion Imaging (HMI)
NCT06779656	Not specified	NOT_YET_RECRUITING	Regional Anesthesia Techniques in Breast Surgery
NCT07505797	Not specified	RECRUITING	ATUSA Ultrasound Diagnostic Imaging for Breast Lesions Evaluation (AUDIBLE)
NCT00910312	Not specified	COMPLETED	ICE-SENSE™ Cryotherapy for Breast Fibroadenoma Trial
NCT01331954	Not specified	UNKNOWN	Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)
NCT01422629	Not specified	COMPLETED	High Intensity Focused Ultrasound (HIFU) to Treat Breast Fibroadenoma
NCT02011919	Not specified	COMPLETED	Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)
NCT02078011	Not specified	COMPLETED	Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound
NCT02139683	Not specified	COMPLETED	Feasibility Study Assessing the Treatment of Fibroadenomata With a Circumferential Sonication Treatment With HIFU
NCT02488655	Not specified	COMPLETED	Treatment of Breast Fibroadenoma With FastScan HIFU
NCT03022695	Not specified	COMPLETED	Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)
NCT03044054	Not specified	COMPLETED	Treatment of Breast Fibroadenoma Targeted Tissue With HIFU
NCT03470051	Not specified	COMPLETED	Case Collection Study in the Evaluation of Doubling Time Rates in Non-Suspicious Breast Masses Using QT Ultrasound Technology
NCT03742401	Not specified	TERMINATED	Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)
NCT03868475	Not specified	WITHDRAWN	Comparing Vacuum-Assisted Percutaneous Excision to Open Surgical Excision for Borderline or High-Risk Breast Lesions
NCT04297007	Not specified	COMPLETED	Pectoral Nerve Block Type-II and Rhomboid Intercostal Block for Pain Management Following Mastectomy Surgery
NCT06016790	Not specified	COMPLETED	Exploring a Breast Cancer Early Screening Model Based on cfDNA
NCT06026176	Not specified	COMPLETED	Pattern of Clinical Presentation of Different Breast Disease in Surgical Opd at BPKIHS

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
TAMOXIFEN	4	4