Bronchopneumonia

Summary

Bronchopneumonia (MONDO:0005682) is a disease with 8 GWAS associations across 8 studies and 3 clinical trials. A subtype of pneumonia — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• GWAS associations: 8
• Clinical trials: 3

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	bronchopneumonia
Mondo ID	MONDO:0005682
EFO	EFO:0007184
MeSH	D001996
DOID	DOID:12375
ICD-11	57624587
NCIT	C26710
SNOMED CT	396285007
UMLS	C0006285
MedGen	2737
Is cancer (heuristic)	no

Also known as: bronchial pneumonia · chest infection - unspecified bronchopneumonia · lobular pneumonia

Data availability: 8 GWAS associations (8 studies).

Disease family

This is a subtype of pneumonia. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › respiratory system disorder › respiratory tract infectious disorder › pneumonia › bronchopneumonia

Related subtypes (10): pleuropneumonia, idiopathic interstitial pneumonia, bacterial pneumonia, contagious pleuropneumonia, eosinophilic pneumonia, recurrent pneumonia, viral pneumonia, pneumocystosis, acute fibrinous and organizing pneumonia, bronchiolocentric pattern of interstitial pneumonia

Genetics & variants

GWAS landscape

8 GWAS associations across 8 studies. Top hits map to 3 distinct genes (as reported by GWAS).

Top associations by p-value

rsID	p-value	Gene	Risk allele	Odds ratio
rs374750913	4e-13	MIR646HG - LINC01718	C	4.11
rs113763611	2e-12	GALNT17	A	4.34
rs188795859	6e-12	FGGY	C	3.17
rs148899520	1e-11	H2ACP1 - SERTM1	C	1.22
rs576101144	2e-11	RAP1BP2 - EZRP1	C	1.61
rs557643483	2e-11	AKR1C6P - U8	C	3.29
rs567562675	4e-11	CBLB	C	2.55
rs75650345	3e-07	BTC - HSPE1P23	?

Top studies (by case count)

Study	Lead author	Year	Cases	Controls	Title
GCST90652031	Liu TY	2025	3,091	198,125	Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population.
GCST90478124	Verma A	2024	1,330	446,327	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90080095	Backman JD	2021	1,056	386,874	Exome sequencing and analysis of 454,787 UK Biobank participants.
GCST90084081	Backman JD	2021	1,056	386,874	Exome sequencing and analysis of 454,787 UK Biobank participants.
GCST90436215	Zhou W	2018	375	398,538	Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.
GCST90044061	Jiang L	2021	297	456,051	A generalized linear mixed model association tool for biobank-scale data.
GCST90480244	Verma A	2024	282	120,865	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90482075	Verma A	2024	282	120,865	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

Tier	Variants
Tier 1: coding	0
Tier 2: splice/UTR	0
Tier 3: regulatory	0
Tier 4: intronic/intergenic	8

MAF distribution

Bucket	Variants
common (>=0.05)	0
low_freq (0.01-0.05)	0
rare (<0.01)	7
unknown	1

Functional consequences

Consequence	Count
intergenic_variant	4
intron_variant	4

Top variants

rsID	Chr	Pos	Alleles	MAF	Consequence	Gene	p-value	Tier
rs374750913	20	61067291	C>A,T	0	intergenic_variant	MIR646HG - LINC01718	4e-13	Tier 4: intronic/intergenic
rs113763611	7	71150260	A>G	0.001	intron_variant	GALNT17	2e-12	Tier 4: intronic/intergenic
rs188795859	1	59364157	C>T	0.001	intron_variant	FGGY	6e-12	Tier 4: intronic/intergenic
rs148899520	13	36508674	C>T	0.006	intergenic_variant	H2ACP1 - SERTM1	1e-11	Tier 4: intronic/intergenic
rs576101144	3	104118339	C>T	0.002	intergenic_variant	RAP1BP2 - EZRP1	2e-11	Tier 4: intronic/intergenic
rs557643483	10	4914337	C>T	0	intron_variant	AKR1C6P - U8	2e-11	Tier 4: intronic/intergenic
rs567562675	3	105709567	C>A	0.001	intron_variant	CBLB	4e-11	Tier 4: intronic/intergenic
rs75650345	4	74811780	G>A		intergenic_variant	BTC - HSPE1P23	3e-07	Tier 4: intronic/intergenic

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	2
PHASE4	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01492387	PHASE4	UNKNOWN	Duration of Antibiotic Therapy in Community - Acquired Pneumonia
NCT06211985	Not specified	COMPLETED	Copeptin: Disease Severity Indicator
NCT06542120	Not specified	UNKNOWN	Research on Body Voice AI Recognition System for Children’s Health Management