Brucellosis
diseaseOn this page
Also known as Cyprus feverRock feverundulant fever
Summary
Brucellosis (MONDO:0005683) is a disease and 8 clinical trials. A subtype of primary bacterial infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: <1 / 1 000 000 (Europe) [Orphanet-validated]
- Phenotypes (HPO): 77
- Clinical trials: 8
Clinical features
Epidemiology
Prevalence records
25 prevalence record(s), Orphanet, top 20 (validated / broadest geography first):
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Annual incidence | <1 / 1 000 000 | 0.09 | Europe | Validated |
| Annual incidence | <1 / 1 000 000 | 0.03 | France | Validated |
| Annual incidence | <1 / 1 000 000 | 0.04 | Austria | Validated |
| Annual incidence | <1 / 1 000 000 | 0.05 | Germany | Validated |
| Annual incidence | 1-9 / 100 000 | 1.13 | Greece | Validated |
| Annual incidence | <1 / 1 000 000 | 0.03 | Ireland | Validated |
| Annual incidence | 1-9 / 1 000 000 | 0.22 | Italy | Validated |
| Annual incidence | <1 / 1 000 000 | 0.01 | Lithuania | Validated |
| Annual incidence | <1 / 1 000 000 | 0.03 | Luxembourg | Validated |
| Annual incidence | <1 / 1 000 000 | 0.05 | Malta | Validated |
| Annual incidence | <1 / 1 000 000 | 0.05 | Norway | Validated |
| Annual incidence | 1-9 / 1 000 000 | 0.35 | Portugal | Validated |
| Annual incidence | 1-9 / 1 000 000 | 0.12 | Spain | Validated |
| Annual incidence | 1-9 / 1 000 000 | 0.15 | Sweden | Validated |
| Annual incidence | <1 / 1 000 000 | 0.02 | United Kingdom | Validated |
| Annual incidence | <1 / 1 000 000 | 0.01 | Romania | Validated |
| Annual incidence | <1 / 1 000 000 | 0.02 | Slovakia | Validated |
| Annual incidence | <1 / 1 000 000 | 0.02 | Slovenia | Validated |
| Annual incidence | <1 / 1 000 000 | 0.02 | Netherlands | Validated |
| Annual incidence | <1 / 1 000 000 | 0.01 | Poland | Validated |
Signs & symptoms
Clinical features (HPO)
77 HPO clinical features (Orphanet curated; top 50 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0001392 | Abnormality of the liver | Very frequent (80-99%) |
| HP:0000975 | Hyperhidrosis | Frequent (30-79%) |
| HP:0001369 | Arthritis | Frequent (30-79%) |
| HP:0001744 | Splenomegaly | Frequent (30-79%) |
| HP:0001824 | Weight loss | Frequent (30-79%) |
| HP:0001882 | Leukopenia | Frequent (30-79%) |
| HP:0001903 | Anemia | Frequent (30-79%) |
| HP:0001945 | Fever | Frequent (30-79%) |
| HP:0002018 | Nausea | Frequent (30-79%) |
| HP:0002039 | Anorexia | Frequent (30-79%) |
| HP:0002240 | Hepatomegaly | Frequent (30-79%) |
| HP:0002829 | Arthralgia | Frequent (30-79%) |
| HP:0003095 | Septic arthritis | Frequent (30-79%) |
| HP:0003237 | Increased circulating IgG level | Frequent (30-79%) |
| HP:0003565 | Elevated erythrocyte sedimentation rate | Frequent (30-79%) |
| HP:0011024 | Abnormality of the gastrointestinal tract | Frequent (30-79%) |
| HP:0011227 | Elevated circulating C-reactive protein concentration | Frequent (30-79%) |
| HP:0012378 | Fatigue | Frequent (30-79%) |
| HP:0025155 | Abnormality of hepatobiliary system physiology | Frequent (30-79%) |
| HP:0025406 | Asthenia | Frequent (30-79%) |
| HP:0000031 | Epididymitis | Occasional (5-29%) |
| HP:0000099 | Glomerulonephritis | Occasional (5-29%) |
| HP:0000119 | Abnormality of the genitourinary system | Occasional (5-29%) |
| HP:0000707 | Abnormality of the nervous system | Occasional (5-29%) |
| HP:0000716 | Depression | Occasional (5-29%) |
| HP:0000951 | Abnormality of the skin | Occasional (5-29%) |
| HP:0000979 | Purpura | Occasional (5-29%) |
| HP:0001508 | Failure to thrive | Occasional (5-29%) |
| HP:0001518 | Small for gestational age | Occasional (5-29%) |
| HP:0001622 | Premature birth | Occasional (5-29%) |
| HP:0001873 | Thrombocytopenia | Occasional (5-29%) |
| HP:0001971 | Hypersplenism | Occasional (5-29%) |
| HP:0001974 | Leukocytosis | Occasional (5-29%) |
| HP:0002011 | Morphological central nervous system abnormality | Occasional (5-29%) |
| HP:0002013 | Vomiting | Occasional (5-29%) |
| HP:0002027 | Abdominal pain | Occasional (5-29%) |
| HP:0002090 | Pneumonia | Occasional (5-29%) |
| HP:0002202 | Pleural effusion | Occasional (5-29%) |
| HP:0002315 | Headache | Occasional (5-29%) |
| HP:0002716 | Lymphadenopathy | Occasional (5-29%) |
| HP:0002754 | Osteomyelitis | Occasional (5-29%) |
| HP:0002923 | Rheumatoid factor positive | Occasional (5-29%) |
| HP:0003496 | Increased circulating IgM level | Occasional (5-29%) |
| HP:0005086 | Knee osteoarthritis | Occasional (5-29%) |
| HP:0005268 | Spontaneous abortion | Occasional (5-29%) |
| HP:0005561 | Abnormality of bone marrow cell morphology | Occasional (5-29%) |
| HP:0008843 | Hip osteoarthritis | Occasional (5-29%) |
| HP:0009830 | Peripheral neuropathy | Occasional (5-29%) |
| HP:0012252 | Abnormal respiratory system morphology | Occasional (5-29%) |
| HP:0012317 | Sacroiliac arthritis | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | brucellosis |
| Mondo ID | MONDO:0005683 |
| EFO | EFO:0007185 |
| MeSH | D002006 |
| Orphanet | 1304 |
| DOID | DOID:11077 |
| ICD-10-CM | A23 |
| ICD-11 | 730510331 |
| NCIT | C84602 |
| SNOMED CT | 75702008 |
| UMLS | C0006309 |
| MedGen | 674 |
| GARD | 0005966 |
| MedDRA | 10006500 |
| NORD | 877 |
| Is cancer (heuristic) | no |
Also known as: Cyprus fever · Rock fever · undulant fever
Disease family
This is a subtype of primary bacterial infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › primary bacterial infectious disease › brucellosis
Related subtypes (36): Buruli ulcer disease, sennetsu fever, salmonellosis, pinta disease, chancroid, gonorrhea, anthrax infection, leprosy, botulism, diphtheria, tetanus, bartonellosis, campylobacteriosis, glanders, granuloma inguinale, legionellosis, leptospirosis, listeriosis, Mycobacterium avium complex disease, ornithosis, rhinoscleroma, staphyloenterotoxemia, syphilis, cholera, ehrlichiosis, melioidosis, tuberculosis, tularemia, plague, Q fever, shigellosis, Lyme disease, relapsing fever, spirillary rat-bite fever, streptobacillary rat-bite fever, Borrelia miyamotoi disease
Subtypes (4): Brucella suis brucellosis, Brucella canis brucellosis, Brucella melitensis brucellosis, Brucella abortus brucellosis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 8.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 8 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06859619 | Not specified | NOT_YET_RECRUITING | Serological Measurement of Montpellier Professionals’ Contacts with Infectious Agents Responsible for Animal-borne Diseases |
| NCT07358910 | Not specified | RECRUITING | Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective |
| NCT01766830 | Not specified | COMPLETED | Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) |
| NCT04301752 | Not specified | COMPLETED | Cognitive Impairment and Neuropsychiatric Manifestations of Neurobrucellosis |
| NCT04717622 | Not specified | UNKNOWN | Investigation of Fever Suspected as a Zoonosis Using Advanced Diagnostic Technologies |
| NCT04911283 | Not specified | COMPLETED | Brucella Serology and History of Brucellosis in Patients With Modic Changes Type 1 |
| NCT06007326 | Not specified | COMPLETED | A Multicentre, Retrospective Study of Clinical Characteristics and Long-term Outcomes of Patients With Brucellosis |
| NCT07112677 | Not specified | COMPLETED | Seroprevalence of Brucella Antibodies in High-Risk Patients With Low Back Pain: A Case-Control Study |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.