Bullous keratopathy
disease diseaseOn this page
Summary
Bullous keratopathy (MONDO:0001180) is a disease and 19 clinical trials. Top therapeutic interventions include fluorometholone, netarsudil, and prednisolone acetate. A subtype of keratopathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 19
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | bullous keratopathy |
| Mondo ID | MONDO:0001180 |
| DOID | DOID:11031 |
| ICD-10-CM | H18.1 |
| ICD-11 | 1270454490 |
| NCIT | C26970 |
| SNOMED CT | 57207003 |
| UMLS | C0155111 |
| MedGen | 57600 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of keratopathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › corneal disorder › keratopathy › bullous keratopathy
Related subtypes (1): band keratopathy
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 19.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 13 |
| PHASE1 | 3 |
| PHASE2 | 2 |
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT03248037 | PHASE3 | COMPLETED | Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation |
| NCT01448213 | PHASE2 | COMPLETED | Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) |
| NCT01926535 | PHASE2 | COMPLETED | Amniotic Membrane Graft In Syntomathic Bullous Keratopathy |
| NCT04319848 | PHASE1 | RECRUITING | Safety and Efficacy of Tissue Engineered Endothelial Keratoplasty |
| NCT05636579 | PHASE1 | RECRUITING | Study to Assess Safety and Tolerability of Multiple Doses of EO2002 |
| NCT04894110 | PHASE1 | COMPLETED | Study of Safety and Tolerability of EO2002 in the Treatment of Corneal Edema |
| NCT05436665 | Not specified | RECRUITING | The Belgian Endothelial Surgical Transplant of the Cornea |
| NCT00659308 | Not specified | COMPLETED | Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous Keratopathy |
| NCT00800111 | Not specified | COMPLETED | Study of Endothelial Keratoplasty Outcomes |
| NCT01106274 | Not specified | COMPLETED | The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous Keratopathy |
| NCT01122043 | Not specified | COMPLETED | The SNEC DSAEK EndoGlide Clinical Trial |
| NCT01682421 | Not specified | WITHDRAWN | Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation |
| NCT02020044 | Not specified | UNKNOWN | Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) |
| NCT02736877 | Not specified | UNKNOWN | Corneal Transplantation Guided by OCT RESCAN |
| NCT03407755 | Not specified | UNKNOWN | Air Versus SF6 for Descemet’s Membrane Endothelial Keratoplasty (DMEK) |
| NCT03450954 | Not specified | COMPLETED | Long Term Results of Amniotic Membrane Transplant in Bullous Keratopathy Patients |
| NCT03763721 | Not specified | COMPLETED | The ADVISE Study: Advanced Visualization In Corneal Surgery Evaluation |
| NCT05891106 | Not specified | COMPLETED | AONDA Therapeutic Indication Study I |
| NCT05956535 | Not specified | COMPLETED | Air Optix® Night and Day® Aqua Therapeutic Wear |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| FLUOROMETHOLONE | 4 | 1 |
| NETARSUDIL | 4 | 1 |
| PREDNISOLONE ACETATE | 4 | 1 |
| RIPASUDIL | 3 | 2 |
| CHEMBL1716015 | 0 | 1 |