Bursitis

Summary

Bursitis (MONDO:0002471) is a disease (an umbrella term covering 5 Mondo subtypes) with 2 GWAS associations across 17 studies and 282 clinical trials. Top therapeutic interventions include lidocaine, amitriptyline, and collagenase clostridium histolyticum. A subtype of arthropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 5 Mondo subtypes
• GWAS associations: 2
• Clinical trials: 282

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	bursitis
Mondo ID	MONDO:0002471
MeSH	D002062
DOID	DOID:2965
ICD-11	1984620329
NCIT	C94407
SNOMED CT	84017003
UMLS	C0006444
MedGen	691
Is cancer (heuristic)	no

Also known as: adhesive Capsulitides · adhesive Capsulitides, shoulder · adhesive capsulitis · adhesive capsulitis of the shoulder · adhesive capsulitis, shoulder · Bursitides · Capsulitides · Capsulitides, adhesive · Capsulitides, shoulder adhesive · capsulitis · capsulitis, adhesive · capsulitis, shoulder adhesive · frozen shoulder · frozen shoulders · inflammation of synovial bursa · shoulder adhesive Capsulitides · shoulder adhesive capsulitis · shoulder, frozen · shoulders, frozen · synovial bursa inflammation

Data availability: 2 GWAS associations (17 studies).

Disease family

This is a subtype of arthropathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › arthropathy › bursitis

Related subtypes (23): transient arthropathy, synovial plica syndrome, hypermobility syndrome, Tietze syndrome, neurogenic arthropathy, Behcet syndrome arthropathy, ankylosis, synovium neoplasm, hydrarthrosis, articular cartilage disorder, hemarthrosis, tenosynovitis, ganglion or cyst of synovium/tendon/bursa, spondyloarthropathy, temporomandibular joint disorder, arthritic joint disease, de Quervain disease, frozen shoulder, patellofemoral pain syndrome, secondary hypertrophic osteoarthropathy, shoulder impingement syndrome, crystal arthropathy, vertebral joint disorder

Subtypes (5): olecranon bursitis, Achilles bursitis, gonococcal bursitis, periarthritis, subacute bursitis

Genetics & variants

GWAS landscape

2 GWAS associations across 17 studies. Top hits map to 0 distinct genes (as reported by GWAS).

Top associations by p-value

rsID	p-value	Gene	Risk allele	Odds ratio
chr4:89054667	2e-11		A	0.13
rs375386343	4e-08	LINC01163 - LINC02667	?

Top studies (by case count)

Study	Lead author	Year	Cases	Controls	Title
GCST90476240	Verma A	2024	13,832	420,337	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90478951	Verma A	2024	6,515	431,740	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90478940	Verma A	2024	4,088	112,729	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90481005	Verma A	2024	4,088	112,729	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90474111	UK Biobank Whole-Genome Sequencing Consortium	2025	3,594	454,846	Whole-genome sequencing of 490,640 UK Biobank participants.
GCST90478939	Verma A	2024	1,816	55,735	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90478950	Verma A	2024	1,712	116,213	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90481010	Verma A	2024	1,712	116,213	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90080528	Backman JD	2021	1,374	384,525	Exome sequencing and analysis of 454,787 UK Biobank participants.
GCST90084514	Backman JD	2021	1,374	384,525	Exome sequencing and analysis of 454,787 UK Biobank participants.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

Tier	Variants
Tier 1: coding	0
Tier 2: splice/UTR	0
Tier 3: regulatory	0
Tier 4: intronic/intergenic	2

MAF distribution

Bucket	Variants
common (>=0.05)	1
low_freq (0.01-0.05)	0
rare (<0.01)	0
unknown	1

Functional consequences

Consequence	Count
unknown	1
non_coding_transcript_exon_variant	1

Top variants

rsID	Chr	Pos	Alleles	MAF	Consequence	Gene	p-value	Tier
chr4:89054667				0.109			2e-11	Tier 4: intronic/intergenic
rs375386343	10	128522512	T>G		non_coding_transcript_exon_variant	LINC01163 - LINC02667	4e-08	Tier 4: intronic/intergenic

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

7 approved, 2 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Dexamethasone	Approved (phase 4)
Hydrocortisone	Approved (phase 4)
Menthol	Approved (phase 4)
Methylprednisolone	Approved (phase 4)
Naproxen	Approved (phase 4)
Prednisone	Approved (phase 4)
Triamcinolone Acetonide	Approved (phase 4)
Ketoprofen	Phase 3 (in late-stage trials)
Sodium Chloride	Phase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 282.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	239
PHASE4	16
PHASE2	11
PHASE3	10
PHASE1/PHASE2	2
PHASE1	2
PHASE2/PHASE3	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02283996	PHASE4	RECRUITING	Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment
NCT07278323	PHASE4	NOT_YET_RECRUITING	Frozen Shoulder and Hormone Replacement Therapy
NCT07416916	PHASE4	RECRUITING	Ultrasound-Guided Intra-Articular vs Gluteal Intramuscular Corticosteroid Injection for Frozen Shoulder
NCT07497737	PHASE4	NOT_YET_RECRUITING	OMT for Adhesive Capsulitis
NCT00160784	PHASE4	COMPLETED	Arthroscopy and Manipulation vs a Home Therapy Program in the Treatment of Adhesive Capsulitis
NCT00863889	PHASE4	WITHDRAWN	Steroid Injection for the Treatment of Greater Trochanteric Pain Syndrome
NCT00875862	PHASE4	TERMINATED	Shoulder Adhesive Capsulitis and Ambulatory Continuous Interscalene Nerve Blocks
NCT01087229	PHASE4	COMPLETED	Effectiveness of an Oxygen-nitrous Oxide Mixture During Physical Therapy for Frozen Shoulder
NCT02001740	PHASE4	COMPLETED	An RCT in Treatment of Adhesive Capsulitis Arthrographic Joint Distention With Local Anesthetic Alone
NCT02944526	PHASE4	COMPLETED	The Effect of 3 Ropivacaine Suprascapular Nerve Blocks in Subacute Adhesive Capsulitis: a Randomized Controlled Trial
NCT03479502	PHASE4	COMPLETED	Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis
NCT03484832	PHASE4	UNKNOWN	Spray vs EMLA Cream on Pain During Intra-articular Injection
NCT04931511	PHASE4	TERMINATED	Comparison Between Subacromial Ultrasound Guided and Systemic Steroid Injection for Frozen Shoulder
NCT04965376	PHASE4	UNKNOWN	A Trial Comparing Glenohumeral Joint Steroid Injection Versus Suprascapular Nerve Block in Patients With Frozen Shoulder
NCT05131269	PHASE4	COMPLETED	Prolotherapy Intervention in Patient With Frozen Shoulder
NCT05844930	PHASE4	COMPLETED	A Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft (ActiveMatrix) Verses Standard of Care in Adhesive Capsulitis of the Shoulder
NCT06848374	PHASE3	RECRUITING	Dose Efficacy in Adhesive Capsulitis
NCT07057037	PHASE3	ACTIVE_NOT_RECRUITING	Phase 3 Study of the Efficacy and Safety of MR Arthrography Using the NEMO-103 Injection in Patients With Known or Suspected Shoulder Joint Diseases
NCT00352625	PHASE3	COMPLETED	Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis
NCT00426985	PHASE3	TERMINATED	Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis
NCT01161615	PHASE3	COMPLETED	MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Tendonitis and Bursitis of the Shoulder
NCT01506154	PHASE3	COMPLETED	Safety & Efficacy Study of MRX-7EAT Patch in the Treatment of Pain of the Shoulder
NCT01570985	PHASE3	UNKNOWN	Treatment Study of Frozen Shoulder: Corticosteroid Injection in Joint Versus Wait and See Policy
NCT01807962	PHASE3	TERMINATED	Local Injection Under US Control in GTPS.
NCT05299242	PHASE2/PHASE3	COMPLETED	The Anti-Freaze-F Study- Anti-TNF for Treatment of Frozen Shoulder - a Feasibility Study
NCT07183436	PHASE3	COMPLETED	Intra-articular Corticosteroids Are Widely Used for Adhesive Capsulitis, But Alternatives Are Required for Patients With Contraindications. Hyaluronic Acid (HA) and Ketorolac Have Shown Individual Benefits. However, Evidence on Their Combination Remains Limited.
NCT07328022	PHASE3	COMPLETED	Efficacy and Safety of Etoricoxib/Betamethasone Combination in Acute Bursitis, Tendinitis and Synovitis
NCT06976671	PHASE2	RECRUITING	A Study to Determine the Safety and Efficacy of Bevacizumab Administered Via Injection Into the Shoulder Joint of Participants With Adhesive Capsulitis (Frozen Shoulder)
NCT00261196	PHASE2	WITHDRAWN	Collagenase in the Treatment of Adhesive Capsulitis (Frozen Shoulder)
NCT01157221	PHASE1/PHASE2	COMPLETED	Prediction Frozen Shoulder Validation
NCT01205477	PHASE2	COMPLETED	Safety and Efficacy of Methylprednisolone Infiltration in Anserine Bursitis Treatment
NCT01306708	PHASE2	COMPLETED	Amitriptyline Regarding Nimesulide in Acute Idiopathic Adhesive Capsulitis
NCT01483963	PHASE2	COMPLETED	AA4500 for the Treatment of Adhesive Capsulitis of the Shoulder
NCT01526031	PHASE2	COMPLETED	Bee Venom Acupuncture for the Treatment of Frozen Shoulder
NCT02006719	PHASE2	COMPLETED	Clinical Study for the Treatment of Adhesive Capsulitis of the Shoulder
NCT02206542	PHASE2	UNKNOWN	Scientifically Merged Acupuncture and Robot-assisted Technology (SMART) for Rehabilitation of Frozen Shoulder Syndrome: Second-year Project-Comparison of Robot and Conventional Physiotherapy (Including Preliminary Test on Healthy Volunteers)
NCT03676829	PHASE1/PHASE2	UNKNOWN	Embolization for the Treatment of Pain Secondary to Adhesive Capsulitis
NCT04160091	PHASE2	TERMINATED	Study to Evaluate the Efficacy and Safety of FX006 in Patients With Glenohumeral Osteoarthritis or Shoulder Adhesive Capsulitis
NCT04496167	PHASE2	COMPLETED	Safety and Efficacy of EN3835 in Participants With Frozen Shoulder
NCT06626568	PHASE2	COMPLETED	Comparison of Ultrasound-Guided Subacromial vs. Systemic Steroid Injections for Frozen Shoulder: a Multicenter Pilot Study

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
LIDOCAINE	4	5
AMITRIPTYLINE	4	3
COLLAGENASE CLOSTRIDIUM HISTOLYTICUM	4	3
DOXYCYCLINE ANHYDROUS	4	3
BETAMETHASONE SODIUM PHOSPHATE	4	1
BUPIVACAINE	4	1
DEXTROSE	4	1
ETORICOXIB	4	1
FLUPHENAZINE DECANOATE	4	1
GUANFACINE HYDROCHLORIDE	4	1
METHYLPREDNISOLONE	4	1
TRIAMCINOLONE ACETONIDE	4	1
TRIAMCINOLONE HEXACETONIDE	4	1
OZONE	3	1
CHEMBL423707	0	1