Calcific tendinitis

Summary

Calcific tendinitis (MONDO:0001903) is a disease and 11 clinical trials. Top therapeutic interventions include dexamethasone, estradiol cypionate, and sodium thiosulfate. A subtype of tendinitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 11

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	calcific tendinitis
Mondo ID	MONDO:0001903
DOID	DOID:14181
ICD-10-CM	M65.2
ICD-11	856383808
SNOMED CT	95414005
UMLS	C0521515
MedGen	636635
GARD	0023035
Is cancer (heuristic)	no

Disease family

This is a subtype of tendinitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › muscle tissue disorder › skeletal muscle disorder › myopathy › myositis disease › tendinitis › calcific tendinitis

Related subtypes (5): patellar tendinitis, tibialis tendinitis, Achilles bursitis, tenosynovitis, paratenonitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 11.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	9
PHASE4	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04126278	PHASE4	TERMINATED	Calcific Tendonitis Treatment: Barbotage vs. Barbotage With Cortisone Injection
NCT04251832	PHASE2	UNKNOWN	Efficacy of Sodium Thiosulfate in Shoulder Pain in Calcific Tendinitis of the Rotator Cuff
NCT07539961	Not specified	NOT_YET_RECRUITING	Paracetamol and Ibuprofen With or Without Famotidine for Calcific Tendinitis of the Shoulder
NCT01538758	Not specified	UNKNOWN	Ultrasound Guided Needling Versus Ultrasound Guided Corticosteroid Injection Alone, a Randomized Controlled Trial.
NCT01832376	Not specified	COMPLETED	Treatment of Calcific Tendinitis by Ultrasound-guided Needle Lavage
NCT02173743	Not specified	COMPLETED	Platelet-rich Plasma in Calcific Tendinitis
NCT02367560	Not specified	UNKNOWN	Calcific Tendinitis: Comparing Minimally Invasive Modalities
NCT03779919	Not specified	UNKNOWN	The Therapeutic Effect of the Extracorporeal Shock Wave Therapy on Shoulder Calcific Tendinitis
NCT05272085	Not specified	COMPLETED	Comparison of the Efficiency of Ultrasound-Guided Lavage and Subacromial Bursa Injection in Calcific Tendinitis
NCT05478902	Not specified	UNKNOWN	Effectiveness of Non-surgical Management in Rotator Cuff Calcific Tendinopathy (THE EFFECT TRIAL)
NCT06528756	Not specified	COMPLETED	Calciying Tendinopathy of the Rotator Cuff: Barbotage Vs Shock Waves

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DEXAMETHASONE	4	1
ESTRADIOL CYPIONATE	4	1
SODIUM THIOSULFATE	4	1
CHEMBL3753202	0	1