CANOMAD syndrome

Summary

CANOMAD syndrome (MONDO:0019109) is a disease. A subtype of acquired peripheral neuropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: <1 / 1 000 000 (Worldwide) [Orphanet-validated]

Clinical features

Epidemiology

Prevalence records

2 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Cases/families		100	Worldwide	Validated
Point prevalence	<1 / 1 000 000		Worldwide	Validated

Identifiers

Disease identifiers

Field	Value
Canonical name	CANOMAD syndrome
Mondo ID	MONDO:0019109
MeSH	C537980
Orphanet	71279
SNOMED CT	715624006
UMLS	C2931684
MedGen	419872
GARD	0009778
Is cancer (heuristic)	no

Also known as: chronic ataxic neuropathy ophthalmoplegia M-protein agglutination disialosyl antibodies syndrome · chronic ataxic neuropathy-ophthalmoplegia-IgM paraprotein-cold agglutinins-disialosyl antibodies syndrome · chronic sensory ataxic neuropathy with anti-disialosyl antibodies · chronic sensory ataxic neuropathy with anti-dyalosyl IgM antibodies

Disease family

Classification path: disease › human disease › disease by body system or component › nervous system disorder › peripheral nervous system disorder › peripheral neuropathy › acquired peripheral neuropathy › CANOMAD syndrome

Related subtypes (11): axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy, cranial neuralgia, neuralgic amyotrophy, POEMS syndrome, non-recovering obstetric brachial plexus lesion, anterior cutaneous nerve entrapment syndrome, pudendal neuralgia, polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG, multifocal motor neuropathy, simple cryoglobulinemia, radiation-induced plexopathy

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.