Carbon monoxide poisoning

Summary

Carbon monoxide poisoning (MONDO:0800373) is a disease and 37 clinical trials. Top therapeutic interventions include dexamethasone and levocarnitine. A subtype of poisoning — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 37

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	carbon monoxide poisoning
Mondo ID	MONDO:0800373
Is cancer (heuristic)	no

Also known as: CO Poisoning

Disease family

This is a subtype of poisoning. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › poisoning › carbon monoxide poisoning

Related subtypes (58): toxic oil syndrome, infantile mercury poisoning, ketamine-induced biliary dilatation, manganese poisoning, cyanide-induced parkinsonism, colchicine poisoning, methanol poisoning, ethylene glycol poisoning, paraquat poisoning, lead poisoning, mercury poisoning, acute opioid poisoning, acute tricyclic antidepressant poisoning, acute poisoning by drugs with membrane-stabilizing effect, snakebite envenomation, paracetamol poisoning, cyanide poisoning, scorpion envenomation, argyria, acute ackee fruit intoxication, cocaine intoxication, systemic monochloroacetate poisoning, water intoxication, cassavism, formaldehyde poisoning, heavy metal poisoning, abacavir toxicity, allopurinol toxicity, codeine toxicity, efavirenz toxicity, flucloxacilline toxicity, isoniazid toxicity, raltegravir toxicity, voriconazole toxicity, curariform drugs toxicity, statin toxicity, phenytoin or carbamazepine toxicity, letrozole toxicity, ricin poisoning, ivermectin toxicity, belinostat toxicity or dose selection, toxicity to dolutegravir, mycotoxicosis, ciguatera fish poisoning, lathyrism, cadmium poisoning, phenytoin toxicity, nerve agent poisoning, local anesthetic poisoning, fire ant poisoning, aflatoxicosis, black widow spider envenomation, platinum-induced ototoxicity, organophosphate poisoning, sulfur mustard poisoning, cardiac glycoside intoxication, monochloroacetic acid poisoning, chemotherapy-induced toxicity

Subtypes (2): carbon monoxide-induced delayed encephalopathy, carbon monoxide-induced parkinsonism

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 37.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	31
PHASE4	2
PHASE3	2
PHASE2	1
PHASE1/PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06811675	PHASE4	RECRUITING	The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning
NCT00465855	PHASE4	COMPLETED	One vs. Three Hyperbaric Oxygen Treatments for Acute Carbon Monoxide Poisoning
NCT01099995	PHASE3	TERMINATED	Hyperbaric Oxygen Therapy for Comatose Patients With Acute Carbon Monoxide Poisoning
NCT01100515	PHASE3	TERMINATED	Hyperbaric Oxygen Therapy for Acute Domestic Carbon Monoxide (CO) Poisoning
NCT06574048	PHASE1/PHASE2	NOT_YET_RECRUITING	Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy
NCT05647707	PHASE2	UNKNOWN	The Efficacy of L-Carnitine in the Management of Acute Carbon Monoxide Poisoning
NCT01758653	Not specified	ENROLLING_BY_INVITATION	Carbon Monoxide Blood and DNA Biorepository
NCT04490317	Not specified	RECRUITING	CARbon monoxidE intoxiCatiOn in Korea: Prospective Cohort (CARE CO Cohort)
NCT04925297	Not specified	NOT_YET_RECRUITING	Neurological Sequelae in Patients With Acute Carbon Monoxide Poisoning
NCT05591300	Not specified	RECRUITING	Microparticles Blood Level in Acute Carbon Monoxide Poisoning
NCT06549621	Not specified	RECRUITING	Cardiotoxicity of Carbon Monoxide in Patients Treated With Hyperbaric Oxygen Therapy
NCT07201181	Not specified	NOT_YET_RECRUITING	Maternal Smoking Exposure and Newborn Outcomes: A Study Using Cord Blood Cotinine
NCT00280579	Not specified	WITHDRAWN	Cyanide Poisoning in Fire Victims
NCT00841165	Not specified	UNKNOWN	Carbon Monoxide Monitoring and Emergency Treatment
NCT01059708	Not specified	TERMINATED	Outcome Following Carbon Monoxide Poisoning in Children
NCT01059981	Not specified	COMPLETED	Analysis of Emergency Department (ED) Volumes During Natural Disasters
NCT02375126	Not specified	UNKNOWN	Normal Quantitative EEG (qEEG) Dataset
NCT02483650	Not specified	UNKNOWN	Hyperbaric Oxygen Therapy Registry
NCT02860455	Not specified	UNKNOWN	Role of Pulse Co-oximetry for Detecting Carbon Monoxide Poisoning in the Prehospital Emergency Medical Service Setting
NCT02931448	Not specified	WITHDRAWN	Occult Carbon Monoxide Poisoning Detection by Pulsated Carboxymetry in an Emergency Department
NCT03004235	Not specified	TERMINATED	Suspected Cases of Carbon Monoxide Poisoning in the ED
NCT03017742	Not specified	TERMINATED	Utility of Non-invasive Carboxyhemoglobin and Total Hemoglobin Measurement in the Emergency Department
NCT03030833	Not specified	COMPLETED	Dysfunctional Hemoglobin Pulse Oximetry
NCT03342209	Not specified	COMPLETED	Utility of High Flow Nasal Cannula in CO Toxicity
NCT03669848	Not specified	COMPLETED	Is Transcutaneous Carbon Monoxide Saturation of E-cigarette Users Comparable to That of Smokers?
NCT03818841	Not specified	UNKNOWN	The Role of High-flow Nasal Cannula Therapy in the Treatment of Acute Carbon Monoxide Poisoning
NCT03926494	Not specified	COMPLETED	Carbon Monoxide-induced Coma: Prognostic Factors
NCT04118491	Not specified	WITHDRAWN	Hyperbaric Oxygen for Carbon Monoxide Induced Chronic Encephalopathy
NCT04419298	Not specified	COMPLETED	Cardiac Magnetic Resonance Image (CMR) in Acute Carbon Monoxide (CO) Poisoning
NCT04475263	Not specified	UNKNOWN	Cognitive and Blood Biomarker Assessment After CO Exposure
NCT04656912	Not specified	COMPLETED	Hyperbaric Oxygen Therapy Initiation Time in Acute Carbon Monoxide Poisoning
NCT04975867	Not specified	COMPLETED	Adjunct Targeted Temperature Management in Acute Severe Carbon Monoxide Poisoning
NCT05088005	Not specified	COMPLETED	Prognostic Biomarkers in CO Poisoning
NCT05110820	Not specified	COMPLETED	Quantitative Assessment of Pupillary Light Reflex in Acute Carbon Monoxide Poisoning
NCT05193812	Not specified	UNKNOWN	Predicitve Value of Copeptin In CO-intoxicated Patients - A Prospective Cohort Study
NCT06198595	Not specified	COMPLETED	Comparison of the Effectiveness of Treatments in Carbon Monoxide Intoxications
NCT06619717	Not specified	TERMINATED	Optimal Number of Hyperbaric Oxygen Treatments for Carbon Monoxide Poisoning

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DEXAMETHASONE	4	2
LEVOCARNITINE	4	1