Central nervous system germ cell tumor
diseaseOn this page
Also known as central nervous system germ cell neoplasmcentral nervous system rare germ cell tumorcentral nervous system rare germ cell tumourCNS germ cell neoplasmCNS germ cell tumorCNS germ cell tumourgerm cell neoplasm of central nervous systemgerm cell neoplasm of CNSgerm cell neoplasm of the central nervous systemgerm cell neoplasm of the CNSgerm cell tumor of central nervous systemgerm cell tumor of CNSgerm cell tumor of the central nervous systemgerm cell tumor of the CNSgerm cell tumour of central nervous systemgerm cell tumour of CNSgerm cell tumour of the central nervous system
Summary
Central nervous system germ cell tumor (MONDO:0003000) is a cancer (an umbrella term covering 6 Mondo subtypes) and 5 clinical trials. Top therapeutic interventions include fludarabine phosphate. A subtype of central nervous system neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 6 Mondo subtypes
- Clinical trials: 5
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | central nervous system germ cell tumor |
| Mondo ID | MONDO:0003000 |
| DOID | DOID:4439 |
| NCIT | C5461 |
| UMLS | C1332880 |
| MedGen | 232040 |
| GARD | 0023321 |
| Anatomy (UBERON) | UBERON:0001017 |
| Is cancer (heuristic) | yes |
Also known as: central nervous system germ cell neoplasm · central nervous system germ cell tumor · central nervous system rare germ cell tumor · central nervous system rare germ cell tumour · CNS germ cell neoplasm · CNS germ cell tumor · CNS germ cell tumour · germ cell neoplasm of central nervous system · germ cell neoplasm of CNS · germ cell neoplasm of the central nervous system · germ cell neoplasm of the CNS · germ cell tumor of central nervous system · germ cell tumor of CNS · germ cell tumor of the central nervous system · germ cell tumor of the CNS · germ cell tumour of central nervous system · germ cell tumour of CNS · germ cell tumour of the central nervous system
Disease family
This is a subtype of central nervous system neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › central nervous system neoplasm › central nervous system germ cell tumor
Related subtypes (9): central nervous system organ benign neoplasm, autonomic nervous system neoplasm, optic nerve neoplasm, central nervous system cancer, central nervous system hematopoietic neoplasm, epidural abscess, tumor of meninges, brain neoplasm, spinal cord neoplasm
Subtypes (6): malignant pineal area germ cell neoplasm, central nervous system germinoma, adult central nervous system germ cell tumor, childhood central nervous system germ cell tumor, mixed germ cell tumor of central nervous system, central nervous system nongerminomatous germ cell tumor
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 5.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 3 |
| PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01270724 | PHASE2 | COMPLETED | Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx) |
| NCT04521946 | PHASE1 | WITHDRAWN | Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer |
| NCT01049230 | Not specified | ACTIVE_NOT_RECRUITING | Proton Beam Radiation Therapy for Central Nervous System (CNS) Germ Cell Tumors |
| NCT05836701 | Not specified | ACTIVE_NOT_RECRUITING | Retrospective Study of Germ Cell Tumors of the Central Nervous System |
| NCT05934630 | Not specified | TERMINATED | Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| FLUDARABINE PHOSPHATE | 4 | 1 |
Related Atlas pages
- Drugs: Fludarabine Phosphate