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Atlas / Disease / Cerebrospinal fluid leak

Cerebrospinal fluid leak

disease
On this page

Also known as cerebrospinal fluid drainagecerebrospinal fluid drainage, post traumaticcerebrospinal fluid drainage, post-traumaticcerebrospinal fluid drainage, spontaneouscerebrospinal fluid drainage, traumaticcerebrospinal fluid Drainagescerebrospinal fluid leak, post traumaticcerebrospinal fluid leak, post-traumaticcerebrospinal fluid leak, spontaneouscerebrospinal fluid leak, traumaticcerebrospinal fluid leakagecerebrospinal fluid leakage, post traumaticcerebrospinal fluid leakage, post-traumaticcerebrospinal fluid leakage, spontaneouscerebrospinal fluid leakage, traumaticcerebrospinal fluid Leakagescerebrospinal fluid LeaksCSF leakCSF otorrhea

Summary

Cerebrospinal fluid leak (MONDO:0043327) is a disease and 34 clinical trials. Top therapeutic interventions include acetazolamide and lidocaine. A subtype of central nervous system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Clinical trials: 34

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical namecerebrospinal fluid leak
Mondo IDMONDO:0043327
MeSHD065634
ICD-10-CMG96.0
SNOMED CT230744007
UMLSC0023182
MedGen9695
Anatomy (UBERON)UBERON:0001359
Is cancer (heuristic)no

Also known as: cerebrospinal fluid drainage · cerebrospinal fluid drainage, post traumatic · cerebrospinal fluid drainage, post-traumatic · cerebrospinal fluid drainage, spontaneous · cerebrospinal fluid drainage, traumatic · cerebrospinal fluid Drainages · cerebrospinal fluid leak · cerebrospinal fluid leak, post traumatic · cerebrospinal fluid leak, post-traumatic · cerebrospinal fluid leak, spontaneous · cerebrospinal fluid leak, traumatic · cerebrospinal fluid leakage · cerebrospinal fluid leakage, post traumatic · cerebrospinal fluid leakage, post-traumatic · cerebrospinal fluid leakage, spontaneous · cerebrospinal fluid leakage, traumatic · cerebrospinal fluid Leakages · cerebrospinal fluid Leaks · CSF leak · CSF otorrhea (+19 more)

Disease family

This is a subtype of central nervous system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › cerebrospinal fluid leak

Related subtypes (18): autoimmune disorder of central nervous system, autonomic nervous system disorder, optic nerve disorder, spinal cord disorder, high pressure neurological syndrome, central nervous system vasculitis, encephalomyelitis, neurodegenerative disease, brain disorder, central nervous system neoplasm, palsy, trigeminal neuralgia, infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly, sporadic fetal brain disruption sequence, congenital narrowing of cervical spinal canal, central nervous system infectious disorder, SPAST-related motor disorder, tinnitus

Subtypes (1): cerebrospinal fluid rhinorrhea

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 34.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified25
PHASE34
PHASE23
PHASE42

Top trials by phase / activity

NCTPhaseStatusTitle
NCT06406790PHASE4RECRUITINGCraniSeal Post Approval Study
NCT03181464PHASE4WITHDRAWNSphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics
NCT01355627PHASE3COMPLETEDTASALL - TachoSil® Against Liquor Leak
NCT02309645PHASE3TERMINATEDThe Paediatric EVICEL® Neuro Study
NCT02457546PHASE3COMPLETEDThe EVICEL® Neurosurgery Phase III Study
NCT02891070PHASE3COMPLETEDEfficacy and Safety of FS VH S/D 500 S-apr (Tisseel) as an Adjunct to Sutured Dural Repair in Cranial Surgery
NCT02902133PHASE2WITHDRAWNAcetazolamide to Prevent Post Operative CSF Leak
NCT03276975PHASE2COMPLETEDA Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment
NCT04351061PHASE2WITHDRAWNAcetazolamide for the Prevention of Post Operative CSF Leak
NCT05898074Not specifiedRECRUITINGRole of Novel RADA16 Hydrogel in Endoscopic Skull Base Surgery
NCT06472505Not specifiedRECRUITINGUsing Polyglycolic Acid Mesh Prevents Cerebrospinal Fluid Leakage
NCT06497634Not specifiedNOT_YET_RECRUITINGEffect of Spinal Needle Type on Optic Nerve Sheath Diameter
NCT06711731Not specifiedRECRUITINGThe Freiburg Registry on SpontanEous IntercrAnial Hypotension (SIH) & Post-duraL Puncture Headache (PDPH)
NCT07092267Not specifiedNOT_YET_RECRUITINGSafety and Efficacy Evaluation of ArtiFix® Sealant Graft in Subjects Requiring Dural Repair Following Neurosurgery
NCT07216157Not specifiedRECRUITINGNoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery
NCT07368348Not specifiedRECRUITINGEvaluation of Internal Nasal Splint-Supported Free Graft Versus Nasoseptal Flap for Endoscopic Skull Base Repair in Cerebrospinal Fluid Leaks
NCT07411690Not specifiedRECRUITINGAnalysis of Cerebrospinal Fluid Leakage After Surgery for Intracranial Tumors
NCT07614399Not specifiedRECRUITINGConservative vs Interventional Management of Postsurgical CSF Pseudomeningocele
NCT01295619Not specifiedCOMPLETEDPerformance and Safety of I-020805 in Prevention of Cerebrospinal Fluid (CSF) Leakage Following Elective Craniotomy
NCT01855425Not specifiedCOMPLETEDCone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose
NCT01977898Not specifiedCOMPLETEDIncidence of Headache Following an Unintentional Dural Puncture
NCT02382692Not specifiedCOMPLETEDCerebrospinal Fluid Rhinorrhea After Functional Endoscopic Sinus Surgery
NCT02876614Not specifiedCOMPLETEDValue of Radionuclide Cisternography
NCT02927782Not specifiedUNKNOWNMobilisation Algorithm After Incidental Durotomy
NCT03566602Not specifiedCOMPLETEDEvaluate the Safety and Performance of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery
NCT04057157Not specifiedCOMPLETEDPost-market Assessment of Biodesign Dural Repair Grafts
NCT04086550Not specifiedCOMPLETEDEvaluate the Safety and Efficacy of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery
NCT04124523Not specifiedCOMPLETEDPerioperative CSF Leak Management - an Opinion Study
NCT04145544Not specifiedCOMPLETEDA Prospective, Randomized, Controlled Multi-center Study of ArtiFascia® Dural Repair Patch Compared With Commercially Available Dural Substitutes. To Evaluate the Safety and Effectiveness of ArtiFascia® in Subjects Requiring Dural Repair.
NCT04490629Not specifiedUNKNOWNThe Efficacy and Safety of a Latest Dural Substitute
NCT04503161Not specifiedWITHDRAWNThe Effect of an ASC-seeded Collagen Hydrogel on Cerebrospinal Fluid Leak Rates Following Skull Base Surgery
NCT04505423Not specifiedCOMPLETEDEvaluation of Outcomes Related to Cerebrospinal Fluid Drain Placement
NCT04923867Not specifiedCOMPLETEDSuturable DuraGen™ PMCF Study
NCT06419855Not specifiedTERMINATEDStudy to Evaluate the Effectivity and Safety of BIOSCAFF®H Compared to DuraGen®, in Patients Undergoing Dural Repair

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
ACETAZOLAMIDE42
LIDOCAINE41

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 20

This page pulls from 20 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvarefogenccgwasgwas_studyhgncicd10cmmedgenmeshmimmondomondochildmondoparentorphanetsctiduberonumls