Cervical disk degenerative disorder
disease diseaseOn this page
Also known as cervical Disc Degenerationcervical Disc degenerative diseasecervical Disc degenerative disordercervical region of vertebral column intervertebral disc degenerative disordercervical region of vertebral column intervertebral disk degenerative disorderdegeneration of cervical intervertebral discdegeneration of cervical intervertebral diskintervertebral disc degenerative disorder of cervical region of vertebral columnintervertebral disk degenerative disorder of cervical region of vertebral column
Summary
Cervical disk degenerative disorder (MONDO:0044343) is a disease and 16 clinical trials. A subtype of intervertebral disk degenerative disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 16
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | cervical disk degenerative disorder |
| Mondo ID | MONDO:0044343 |
| EFO | EFO:0009537 |
| NCIT | C27156 |
| SNOMED CT | 69195002 |
| UMLS | C0410606 |
| MedGen | 96081 |
| Anatomy (UBERON) | UBERON:0006072 |
| Is cancer (heuristic) | no |
Also known as: cervical Disc Degeneration · cervical Disc degenerative disease · cervical Disc degenerative disorder · cervical region of vertebral column intervertebral disc degenerative disorder · cervical region of vertebral column intervertebral disk degenerative disorder · degeneration of cervical intervertebral disc · degeneration of cervical intervertebral disk · intervertebral disc degenerative disorder of cervical region of vertebral column · intervertebral disk degenerative disorder of cervical region of vertebral column
Disease family
This is a subtype of intervertebral disk degenerative disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › vertebral column disorder › intervertebral disk degenerative disorder › cervical disk degenerative disorder
Related subtypes (2): lumbar disk degenerative disorder, thoracic disk degenerative disorder
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 16.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 14 |
| PHASE4 | 1 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04550923 | PHASE4 | RECRUITING | Comparison of Rigid and Non-Rigid Interbody Fusion Device for Cervical Degenerative Disc Disease in Adults |
| NCT01607775 | PHASE1/PHASE2 | COMPLETED | In-house Produced PMMA- Versus PEEK-cages |
| NCT04214535 | Not specified | ACTIVE_NOT_RECRUITING | Anterior Cervical Disectomy And Fusion Using The Tritanium® C Anterior Cervical Cage For One Or Two-Levels |
| NCT04623593 | Not specified | RECRUITING | Cervical Arthroplasty Cost Effectiveness Study (CACES) |
| NCT04982835 | Not specified | ACTIVE_NOT_RECRUITING | M6-C Artificial Cervical Disc Two-Level IDE Pivotal Study |
| NCT05305430 | Not specified | RECRUITING | Real World Data Collection on the Synergy Cervical Disc |
| NCT05631392 | Not specified | ACTIVE_NOT_RECRUITING | Study to Evaluate the Clinical and Radiographic Outcomes of the BEE® HA Cage for Anterior Cervical Discectomy and Fusion |
| NCT07556978 | Not specified | NOT_YET_RECRUITING | Post-market Observational Clinical Study With the CE-marked Implantable Class IIb Medical Device ITC CERVICAL |
| NCT00478088 | Not specified | COMPLETED | Evaluating The Safety and Effectiveness of The NeoDisc™ Versus ACDF in Subjects With Single-Level Cervical Disc Disease |
| NCT02182843 | Not specified | COMPLETED | Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn) |
| NCT03077516 | Not specified | COMPLETED | Post-Market, Long-Term Follow Up of Mobi-C® Cervical Disc for One and Two Level Treatment of Cervical Disc Disease |
| NCT03360409 | Not specified | UNKNOWN | Compare Different Cervical Anterior Discectomy Procedures by After Procedure Sagittal Alignment on Radiograph |
| NCT04605120 | Not specified | UNKNOWN | Allogeinic Bone Paste |
| NCT04627454 | Not specified | UNKNOWN | Dynamic Cervical Implant in Treatment of Cervical Disc Disease |
| NCT05101057 | Not specified | UNKNOWN | A Retrospective Study to Examine the Effect of CMF Stimulation on Primary ACDF Patients |
| NCT05602714 | Not specified | UNKNOWN | Real World Data Collection and Analysis on the Anterior Cervical Spine Surgery |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CHEMBL1271166 | 0 | 1 |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.