Cervical dystonia

Summary

Cervical dystonia (MONDO:0000481) is a disease and 84 clinical trials. Top therapeutic interventions include botulinum toxin type a, valbenazine, and daxibotulinumtoxina. A subtype of focal dystonia — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 84

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	cervical dystonia
Mondo ID	MONDO:0000481
Orphanet	93962
DOID	DOID:0050840
ICD-11	1435836279
NCIT	C85072
SNOMED CT	74333002
UMLS	C0152116
MedGen	101818
GARD	0027529
Is cancer (heuristic)	no

Disease family

This is a subtype of focal dystonia. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › movement disorder › extrapyramidal and movement disease › dystonic disorder › focal dystonia › cervical dystonia

Related subtypes (11): anismus, focal hand dystonia, oculogyric crisis, spasmodic dystonia, craniofacial dystonia, X-linked dystonia-parkinsonism, torsion dystonia 7, benign essential blepharospasm, dystonia 23, oromandibular dystonia, dystonia, focal, task-specific

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 84.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	46
PHASE3	13
PHASE2	12
PHASE4	8
PHASE1/PHASE2	2
PHASE1	2
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00541905	PHASE4	COMPLETED	Daily Dystonia Practice - A Trial to Investigate NT 201, the Duration of Treatment Effect After One Injection Session and in Long-term Treatment in Cervical Dystonia
NCT00702754	PHASE4	COMPLETED	Open Label Safety/Immunogenicity Study of MYOBLOC (Neurobloc; Botulinum Toxin Type B) in Patients With Cervical Dystonia
NCT00773253	PHASE4	COMPLETED	Botox for Cervical Dystonia Following EMG Mapping
NCT00950664	PHASE4	COMPLETED	A Study to Compare Dysport® and Botox® in the Treatment of Cervical Dystonia
NCT01486264	PHASE4	COMPLETED	Open-Label Non-Inferiority Study Evaluating the Efficacy and Safety of Xeomin® in Subjects With Cervical Dystonia Flex
NCT01664013	PHASE4	UNKNOWN	The Impact of Botulinum Toxin Treatment in Quality of Life of Cervical Dystonia Patients
NCT02177617	PHASE4	COMPLETED	Neurotoxin and Physical Therapy
NCT05157100	PHASE4	COMPLETED	Clinical Study of Ingrezza (Valbenazine) for the Treatment of Cervical Dystonia
NCT00148889	PHASE3	COMPLETED	Double-blind, Multicenter Study to Assess the Efficacy of Bilateral Pallidal Stimulation in Patients With Medically Refractory Primary Cervical Dystonia
NCT00257660	PHASE3	COMPLETED	Randomized, Placebo-Controlled Study of AbobotulinumtoxinA (Dysport®) for the Treatment of Cervical Dystonia
NCT00288509	PHASE3	COMPLETED	Open-label Extension Study of AbobotulinumtoxinA (Dysport®) for the Treatment of Cervical Dystonia
NCT00407030	PHASE3	COMPLETED	IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Cervical Dystonia
NCT00447772	PHASE3	COMPLETED	Study to Assess the Efficacy and Safety of Dysport® in Cervical Dystonia
NCT01261611	PHASE3	COMPLETED	Study Comparing Short Term Efficacy of Dysport and Dysport NG to Placebo, and to Assess Efficacy and Safety of Dysport NG of Subjects With Cervical Dystonia
NCT01753310	PHASE3	COMPLETED	Efficacy and Safety of DYSPORT® Using 2mL Dilution in Adults With Cervical Dystonia.
NCT01753336	PHASE3	COMPLETED	Long Term Safety And Effectiveness Of Dysport® In Adults With Cervical Dystonia
NCT03608397	PHASE3	COMPLETED	Single Treatment of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-1)
NCT03617367	PHASE3	COMPLETED	Long-Term Safety and Efficacy of Repeat Treatments of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-OLS)
NCT03805152	PHASE3	COMPLETED	Abobotulinum Toxin and Neubotulinum Toxin Injection in Cerivical Dystonia
NCT03905304	PHASE3	COMPLETED	Efficacy and Safety of MEDITOXIN® in Cervical Dystonia
NCT04582929	PHASE3	COMPLETED	Neubotulinum Toxin Injection in Cerivical Dystonia
NCT06771323	PHASE2	RECRUITING	Safety and Effectiveness of Valbenazine as Adjunct Therapy to Botulinum Toxin Injections in Cervical Dystonia
NCT06937931	PHASE2	RECRUITING	A Study of IPN10200 for the Treatment of Cervical Dystonia in Adults
NCT07140874	PHASE2	RECRUITING	Zinc as an Adjunctive Therapy for Cervical Dystonia
NCT00165776	PHASE2	COMPLETED	Randomized, Double-Blind, Placebo-Controlled, Parallel, Group Dose-Response, Study of E2014 in Patients WIth Spasmodic Torticollis
NCT00178945	PHASE1/PHASE2	COMPLETED	Botulinum Toxin Type A (Botox) for the Treatment of Cervical Dystonia and Upper Thoracic Muscular Pain
NCT00418925	PHASE2	UNKNOWN	Efficacy of Dronabinol for the Treatment of Cervical Dystonia
NCT00564681	PHASE2	COMPLETED	Study to Evaluate Safety, Efficacy of Botulinum Toxin Type A in Patients With Cervical Dystonia
NCT00760318	PHASE2	TERMINATED	Keppra for Cervical Dystonia
NCT01588574	PHASE2	COMPLETED	Study for Determine the Safety and Efficacy of Clostridium Botulinum Toxin Type A in Subjects With Cervical Dystonia
NCT02131467	PHASE1/PHASE2	COMPLETED	Safety and Tolerability of Perampanel in Cervical Dystonia
NCT02662530	PHASE2	UNKNOWN	Clinical and Kinematic Assessment for Determination of Botox® Injection Parameters in Cervical Dystonia
NCT04849988	PHASE2	COMPLETED	A Phase 2 Study to Evaluate the Safety and Efficacy of ABP-450 in the Treatment of Cervical Dystonia
NCT04871451	PHASE2	COMPLETED	Extension Study of ABP-19000 to Evaluate Safety and Efficacy of Repeat Treatments of ABP-450 in Cervical Dystonia
NCT06830642	PHASE2	SUSPENDED	Study of the Oral Treatment MTR-601 in Cervical Dystonia
NCT00132340	PHASE1	COMPLETED	Deep Brain Stimulation to Treat Cervical Dystonia
NCT04171258	PHASE1	COMPLETED	Clinical Trial to Compare the Safety and Efficacy of Botulax® Versus Botox® in Patients With Cervical Dystonia
NCT02504905	EARLY_PHASE1	COMPLETED	Propensity to Develop Plasticity in the Parieto-Motor Networks in Dystonia From the Perspective of Abnormal High-Order Motor Processing
NCT05715138	Not specified	NOT_YET_RECRUITING	Comparison of Pallidal With Subthalamic Deep Brain Stimulation for Cervical Dystonia
NCT06748846	Not specified	ACTIVE_NOT_RECRUITING	Segmental Muscle Vibration on Pain in Patients With Primary Cervical Dystonia

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
BOTULINUM TOXIN TYPE A	4	10
VALBENAZINE	4	3
DAXIBOTULINUMTOXINA	4	2
PRABOTULINUMTOXIN A	4	2
RIMABOTULINUMTOXINB	4	2
CITRIC ACID	4	1
DRONABINOL	4	1
PERAMPANEL	4	1
NIVOBOTULINUMTOXINA	3	1
ZINC ION	3	1
CHEMBL1201279	0	1
CHEMBL46909	0	1