Cervical small cell carcinoma

Summary

Cervical small cell carcinoma (MONDO:0006142) is a cancer and 11 clinical trials. Top therapeutic interventions include fludeoxyglucose f 18, topotecan hydrochloride, and veliparib. A subtype of small cell carcinoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 11

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	cervical small cell carcinoma
Mondo ID	MONDO:0006142
EFO	EFO:1000171
DOID	DOID:6740
NCIT	C7982
UMLS	C0279674
MedGen	79025
GARD	0024309
Anatomy (UBERON)	UBERON:0000002
Is cancer (heuristic)	yes

Also known as: Cervical small cell cancer · cervical small cell carcinoma · cervix small cell carcinoma · cervix uteri small cell carcinoma · SCCE · small cell carcinoma of cervix · small cell carcinoma of cervix uteri · small cell carcinoma of the cervix · small cell carcinoma of the cervix uteri · small cell carcinoma of the uterine cervix · small cell carcinoma of uterine cervix · uterine cervix small cell carcinoma

Data availability: 4 cell lines.

Disease family

This is a subtype of small cell carcinoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › carcinoma › neuroendocrine carcinoma › small cell carcinoma › cervical small cell carcinoma

Related subtypes (17): extrahepatic bile duct small cell adenocarcinoma, ovarian small cell carcinoma, colon small cell neuroendocrine carcinoma, urinary bladder small cell neuroendocrine carcinoma, esophageal small cell neuroendocrine carcinoma, ampulla of vater small cell neuroendocrine carcinoma, Bartholin gland small cell carcinoma, thymus small cell carcinoma, endometrial small cell carcinoma, gallbladder small cell neuroendocrine carcinoma, gastric small cell neuroendocrine carcinoma, laryngeal small cell carcinoma, pancreatic small cell neuroendocrine carcinoma, prostate small cell carcinoma, salivary gland small cell carcinoma, ureter small cell carcinoma, small cell lung carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 11.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	4
PHASE1	3
Not specified	3
PHASE1/PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07276360	PHASE2	RECRUITING	Hypofractionated Radiotherapy for the Treatment of Locally Advanced Cervical Cancer in Uganda
NCT00217633	PHASE2	COMPLETED	Pelvic Exenteration in Treating Patients With Recurrent Cervical Cancer
NCT00309959	PHASE2	COMPLETED	ABI-007 in Treating Patients With Persistent or Recurrent Cervical Cancer
NCT00416455	PHASE1/PHASE2	COMPLETED	Fludeoxyglucose (FDG) F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer
NCT01266447	PHASE2	COMPLETED	Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical Cancer
NCT00068549	PHASE1	COMPLETED	Radiation Therapy Plus Cisplatin and Gemcitabine in Treating Patients With Cervical Cancer
NCT00104910	PHASE1	COMPLETED	Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer
NCT02164461	PHASE1	COMPLETED	Axalimogene Filolisbac (ADXS11-001) High Dose in Women With Human Papillomavirus (HPV) + Cervical Cancer
NCT04723095	Not specified	RECRUITING	Establishing a Tumor Registry for Patients With Neuroendocrine Carcinoma of the Cervix
NCT00460356	Not specified	COMPLETED	Glycoprotein and Glycan in Tissue and Blood Samples of Patients With Stage IB-IVA Cervical Cancer Undergoing Surgery to Remove Pelvic and Abdominal Lymph Nodes
NCT00897442	Not specified	COMPLETED	Collecting Tumor Samples From Patients With Gynecological Tumors

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
FLUDEOXYGLUCOSE F 18	4	1
TOPOTECAN HYDROCHLORIDE	4	1
VELIPARIB	3	2
FERUMOXTRAN-10	3	1