Cervical squamous intraepithelial neoplasia

Summary

Cervical squamous intraepithelial neoplasia (MONDO:0042491) is a disease and 18 clinical trials. Top therapeutic interventions include human papillomavirus, l1 protein virus like particles and iopamidol. A subtype of uterine cervix neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 18

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	cervical squamous intraepithelial neoplasia
Mondo ID	MONDO:0042491
MeSH	D065310
NCIT	C7346
UMLS	C1332922
MedGen	234116
GARD	0025850
Anatomy (UBERON)	UBERON:0000002
Is cancer (heuristic)	no

Also known as: cervical sil · cervical squamous intraepithelial lesion · cervical squamous intraepithelial neoplasia · cervix squamous intraepithelial lesion · cervix uteri sil · cervix uteri squamous intraepithelial lesion · CIN · squamous intraepithelial lesion of cervix · squamous intraepithelial lesion of cervix uteri · squamous intraepithelial lesion of the cervix · squamous intraepithelial lesion of the cervix uteri · squamous intraepithelial lesion of the uterine cervix · squamous intraepithelial lesion of uterine cervix · uterine cervix sil · uterine cervix squamous intraepithelial lesion

Disease family

This is a subtype of uterine cervix neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › uterine disorder › cervix disorder › uterine cervix neoplasm › cervical squamous intraepithelial neoplasia

Related subtypes (4): cervical benign neoplasm, cervical cancer, nabothian cyst, uterine ligament neoplasm

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 18.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	14
PHASE4	1
PHASE3	1
PHASE2	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00289029	PHASE4	COMPLETED	A Study of Two Iodinated Contrast Agents in Renally Impaired Patients Undergoing Cardiac Angiography
NCT05580341	PHASE3	UNKNOWN	Phase III Study Comparing the Immunogenicity of 9-valent HPV Recombinant Vaccine and Gardasil-9
NCT07545746	PHASE2	NOT_YET_RECRUITING	Adjuvant 5-Fluorouracil Following Thermal Ablation to Improve HPV Treatment Outcomes in Women With HIV in Kenya
NCT03239223	PHASE1	COMPLETED	Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection
NCT05613283	Not specified	ACTIVE_NOT_RECRUITING	Primary Cervical Cancer Screening by Self-sampling HPV Test
NCT06147388	Not specified	RECRUITING	Regression of Cervical Precancerous Lesions and Associated Risk Factors
NCT00339989	Not specified	COMPLETED	Cervical Cancer Early Endpoints and Determinants
NCT01766284	Not specified	COMPLETED	Study of the Diagnostic Efficacy of Real Time Niris 1300e Optical Coherence Tomography (OCT) Imaging System in the Management of Pre-invasive and Invasive Neoplasia of the Uterine Cervix
NCT01836588	Not specified	UNKNOWN	New Gentle Biopsy Method of Cervix Lesions Using Superficial Curettage/Protocol ID: CX-CUR
NCT02116920	Not specified	UNKNOWN	HPV E6/E7 mRNA Versus HPV DNA as Triage for Cervical Cancer Screening
NCT02140021	Not specified	TERMINATED	Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer
NCT02363244	Not specified	COMPLETED	Pap and HPVDNA Before and After Acetic Acid
NCT03791606	Not specified	COMPLETED	Risk Factors,PREvention and OutComes for CI-AKI in PatientS undErgoing PCI at Intensive Care Unit(PRECISE-ICU)
NCT03872739	Not specified	UNKNOWN	To Compare Intravenous and Oral Hydration of the Prevention for CIN in Elderly Patients Undergoing Intravenous CECT
NCT04809727	Not specified	COMPLETED	Histopathological Findings in Symptomatizing Patients After Supracervical Hysterectomy
NCT05210348	Not specified	UNKNOWN	Clinical Evaluation of Detection of High Risk HPV in Urine
NCT06261879	Not specified	UNKNOWN	Non-invasive Biomarker Discovery for Pre-cervical or/and Cervical Cancer–ACTN4 and Other Biomarkers in Menstrual Blood
NCT07020130	Not specified	COMPLETED	Risk Factors,PREvention and OutComes for CI-AKI in PatientS undErgoing PCI (PRECISE)

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
HUMAN PAPILLOMAVIRUS, L1 PROTEIN VIRUS LIKE PARTICLES	4	1
IOPAMIDOL	4	1
CHEMBL4759972	0	1