Chalazion

Summary

Chalazion (MONDO:0005844) is a disease and 14 clinical trials. Top therapeutic interventions include loteprednol etabonate, tetracycline, and triamcinolone. A subtype of internal hordeolum — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 14

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	chalazion
Mondo ID	MONDO:0005844
EFO	EFO:0007363
MeSH	D017043
DOID	DOID:9903
ICD-10-CM	H00.1
ICD-11	777918741
NCIT	C26717
SNOMED CT	1482004
UMLS	C0007933
MedGen	869
Is cancer (heuristic)	no

Also known as: chalazia · chalazion · cyst, Meibomian · Meibomian cyst

Disease family

This is a subtype of internal hordeolum. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye adnexa disorder › eyelid disorder › blepharitis › hordeolum › internal hordeolum › chalazion

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 2 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Fluorouracil	Phase 3 (in late-stage trials)
Triamcinolone Acetonide	Phase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 14.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	8
PHASE3	2
PHASE4	1
PHASE2/PHASE3	1
PHASE2	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00420628	PHASE4	COMPLETED	Pediatric Zylet Safety and Efficacy Study
NCT02025023	PHASE3	RECRUITING	Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study
NCT01202747	PHASE2/PHASE3	COMPLETED	Evaluation of Screening Methods for Treatment of Meibomian Gland Dysfunction
NCT03248440	PHASE3	COMPLETED	Safety and Efficacy Study of SUN-131 Transdermal System (TDS) as Compared to Placebo TDS in Patients With a Chalazion
NCT02338648	PHASE2	COMPLETED	Safety and Efficacy Study of SUN 131 TDS as Compared to Placebo TDS in Adult Patients With a Chalazion
NCT01763437	EARLY_PHASE1	WITHDRAWN	Intralesional Tetracycline Injection in the Treatment of Chalazia
NCT07405138	Not specified	NOT_YET_RECRUITING	Evaluation of Effectiveness and Safety of Intense Pulsed Light Treatment for Chalazion
NCT07450495	Not specified	RECRUITING	Effect of Different Concentrations of Sevoflurane for Anesthesia Induction in Pediatric Ophthalmic Surgery
NCT00832130	Not specified	COMPLETED	Treatment of Meibomian Gland Dysfunction and Evaporative Dry Eye
NCT04322500	Not specified	COMPLETED	Probiotics for Chalaziosis Treatment in Children
NCT04342507	Not specified	COMPLETED	Probiotics for Treatment of Chalazion in Adults
NCT05070611	Not specified	UNKNOWN	Efficacy of Intense Pulsed Light in the Treatment of Recurrent Chalazia
NCT05512572	Not specified	UNKNOWN	Therapeutic Efficacy of Intense Pulsed Light in the Treatment of Chalazion
NCT07039461	Not specified	TERMINATED	Evaluation of Effectiveness and Safety of Intense Pulsed Light Treatment for Chalazion

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
LOTEPREDNOL ETABONATE	4	1
TETRACYCLINE	4	1
TRIAMCINOLONE	4	1
TRIAMCINOLONE ACETONIDE	4	1
CHEMBL4854670	0	1
VEHICLE	0	1