Chandler syndrome

Summary

Chandler syndrome (MONDO:0020369) is a disease and 3 clinical trials. A subtype of corneal dystrophy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 3

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	Chandler syndrome
Mondo ID	MONDO:0020369
Orphanet	98979
DOID	DOID:11554
ICD-11	806443940
UMLS	C0544008
MedGen	107777
GARD	0006033
MedDRA	10057487
NORD	918
Is cancer (heuristic)	no

Also known as: Chandler’s Syndrome · Chandler’s syndrome · endothelial corneal dystrophy

Disease family

This is a subtype of corneal dystrophy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › corneal disorder › corneal dystrophy › Chandler syndrome

Related subtypes (12): epithelial and subepithelial corneal dystrophy, epithelial-stromal TGFBI dystrophy, corneal endothelial dystrophy, Finnish type amyloidosis, autosomal dominant keratitis, macular dystrophy, fenestrated sheen type, band keratopathy, superficial corneal dystrophy, stromal corneal dystrophy, posterior corneal dystrophy, Judge Misch wright syndrome, corneal dystrophy, punctiform and polychromatic pre-descemet

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03763721	Not specified	COMPLETED	The ADVISE Study: Advanced Visualization In Corneal Surgery Evaluation
NCT04469933	Not specified	COMPLETED	Predictive Factors of Good Results After Primary Descemet’s Membrane Endothelial Keratoplasty (DMEK)
NCT06101017	Not specified	COMPLETED	Developing a Nationwide Registry to Track Longitudinal Clinical Outcomes of Corneal Surgery and Disease