Childhood choroid plexus neoplasm

Summary

Childhood choroid plexus neoplasm (MONDO:0024744) is a cancer and 4 clinical trials. Top therapeutic interventions include onc-206. A subtype of choroid plexus neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 4

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	childhood choroid plexus neoplasm
Mondo ID	MONDO:0024744
NCIT	C42080
UMLS	C0280623
MedGen	76132
GARD	0025460
Is cancer (heuristic)	yes

Also known as: childhood choroid plexus neoplasm · choroid plexus neoplasm · choroid plexus neoplasm of childhood · paediatric choroid plexus neoplasm · pediatric choroid plexus neoplasm

Disease family

This is a subtype of choroid plexus neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › brain disorder › brain neoplasm › choroid plexus neoplasm › childhood choroid plexus neoplasm

Related subtypes (4): choroid plexus cancer, adult choroid plexus neoplasm, atypical choroid plexus papilloma, benign choroid plexus neoplasm

Subtypes (1): childhood choroid plexus carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 4.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE1	2
Not specified	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04541082	PHASE1	RECRUITING	Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
NCT01975116	PHASE1	COMPLETED	p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors
NCT00919750	Not specified	COMPLETED	Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors
NCT02162732	Not specified	COMPLETED	Molecular-Guided Therapy for Childhood Cancer

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ONC-206	1	1