Childhood testicular germ cell tumor

Summary

Childhood testicular germ cell tumor (MONDO:0003758) is a cancer and 81 clinical trials. Top therapeutic interventions include ifosfamide, bleomycin sulfate, and cyclophosphamide anhydrous. A subtype of testicular germ cell tumor — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 81

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	childhood testicular germ cell tumor
Mondo ID	MONDO:0003758
DOID	DOID:6082
NCIT	C6552
UMLS	C0796663
MedGen	208758
GARD	0023653
Is cancer (heuristic)	yes

Also known as: childhood testicular germ cell neoplasm · childhood testicular germ cell tumor · pediatric testicular germ cell neoplasm · pediatric testicular germ cell tumor · testicular germ cell tumor · testicular germ cell tumor of childhood · testicular germ cell tumour · testicular germ cell tumour of childhood

Disease family

This is a subtype of testicular germ cell tumor. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › germ cell tumor › gonadal germ cell tumor › testicular germ cell tumor › childhood testicular germ cell tumor

Related subtypes (5): testicular pure germ cell tumor, malignant testicular germ cell tumor, testicular non-seminomatous germ cell tumor, testicular germ cell tumor 1, testicular teratoma

Subtypes (3): childhood testicular choriocarcinoma, childhood testicular mixed germ cell cancer, childhood embryonal testis carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 81.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	28
Not specified	23
PHASE3	12
PHASE1/PHASE2	9
PHASE1	8
PHASE2/PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00002566	PHASE3	COMPLETED	Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors
NCT00002596	PHASE3	COMPLETED	Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors
NCT00003014	PHASE3	COMPLETED	Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer
NCT00003643	PHASE2/PHASE3	UNKNOWN	Combination Chemotherapy in Treating Men With Germ Cell Cancer
NCT00003941	PHASE3	COMPLETED	Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer
NCT00004219	PHASE3	UNKNOWN	Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma
NCT00005590	PHASE3	COMPLETED	Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma
NCT00072215	PHASE3	TERMINATED	Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors
NCT00104676	PHASE3	COMPLETED	Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors
NCT00324298	PHASE3	COMPLETED	Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles
NCT00324324	PHASE3	TERMINATED	Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant
NCT00589537	PHASE3	UNKNOWN	Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle
NCT01087268	PHASE3	UNKNOWN	Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer
NCT06041503	PHASE2	RECRUITING	Enfortumab Vedotin With or Without Pembrolizumab in Rare Genitourinary Tumors (E-VIRTUE)
NCT00002508	PHASE1/PHASE2	COMPLETED	Combination Chemotherapy Followed by Bone Marrow or Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Germ Cell Tumors
NCT00002515	PHASE2	COMPLETED	Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer
NCT00002558	PHASE1/PHASE2	COMPLETED	Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors
NCT00002559	PHASE1/PHASE2	COMPLETED	Combination Chemotherapy in Treating Patients With Germ Cell Tumors That Have Not Responded to Previous Cisplatin
NCT00002903	PHASE2	COMPLETED	Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer
NCT00002931	PHASE2	COMPLETED	Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer
NCT00002943	PHASE2	COMPLETED	Carboplatin, Etoposide, Cyclophosphamide, and Autologous Bone Marrow Transplantation in Patients With Relapsed or Refractory Cancer
NCT00003173	PHASE2	COMPLETED	High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors
NCT00003408	PHASE2	COMPLETED	Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer
NCT00003518	PHASE2	COMPLETED	Paclitaxel Plus Gemcitabine in Treating Patients With Refractory Metastatic Germ Cell Tumors
NCT00003657	PHASE2	COMPLETED	High-dose ICE With Amifostine
NCT00003852	PHASE2	TERMINATED	Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors
NCT00003887	PHASE2	COMPLETED	Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation
NCT00004077	PHASE2	COMPLETED	Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer
NCT00004157	PHASE2	COMPLETED	Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin’s Lymphoma, Hodgkin’s Disease, Breast Cancer, or Other Solid Tumors
NCT00005952	PHASE1/PHASE2	COMPLETED	Temozolomide Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Malignant Glioma or Recurrent CNS or Other Solid Tumors
NCT00006043	PHASE2	COMPLETED	Temozolomide in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to Cisplatin
NCT00010283	PHASE1/PHASE2	COMPLETED	Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon
NCT00019331	PHASE2	COMPLETED	Vaccine Therapy Plus Biological Therapy in Treating Adults With Metastatic Solid Tumors
NCT00036842	PHASE2	COMPLETED	Arsenic Trioxide in Treating Men With Germ Cell Cancer
NCT00060255	PHASE2	COMPLETED	High-Dose Chemotherapy, Total-Body Irradiation, and Autologous Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Hematologic Cancer or Solid Tumors
NCT00064311	PHASE1/PHASE2	COMPLETED	Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation
NCT00070096	PHASE2	COMPLETED	Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors
NCT00109993	PHASE2	COMPLETED	Campath-1H + FK506 and Methylprednisolone for GVHD
NCT00301782	PHASE2	COMPLETED	Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors
NCT00410657	PHASE2	COMPLETED	Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
IFOSFAMIDE	4	15
BLEOMYCIN SULFATE	4	7
CYCLOPHOSPHAMIDE ANHYDROUS	4	6
GRANISETRON	4	6
CISPLATIN	4	4
ETOPOSIDE	4	4
THIOTEPA	4	4
CARBOPLATIN	4	3
FILGRASTIM	4	3
VINBLASTINE	4	3
ALEMTUZUMAB	4	2
DASATINIB ANHYDROUS	4	2
ETOPOSIDE PHOSPHATE	4	2
LEVOFLOXACIN ANHYDROUS	4	2
SARGRAMOSTIM	4	2
ALDESLEUKIN	4	1
AMIFOSTINE	4	1
ARSENIC TRIOXIDE	4	1
BECLOMETHASONE DIPROPIONATE	4	1
CARMUSTINE	4	1
ENFORTUMAB VEDOTIN	4	1
EPIRUBICIN HYDROCHLORIDE	4	1
IXABEPILONE	4	1
LENOGRASTIM	4	1
MOXIFLOXACIN HYDROCHLORIDE	4	1
OFLOXACIN	4	1
OXALIPLATIN	4	1
PACLITAXEL	4	1
PALBOCICLIB	4	1
SUNITINIB MALATE	4	1