Chlamydia infectious disease

Summary

Chlamydia infectious disease (MONDO:0021697) is a disease with 6 GWAS associations across 1 studies and 24 clinical trials. Top therapeutic interventions include erythromycin, estradiol, and estrogen. A subtype of bacterial sexually transmitted disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• GWAS associations: 6
• Clinical trials: 24

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	chlamydia infectious disease
Mondo ID	MONDO:0021697
EFO	EFO:1000863
MeSH	D002690, D023521
ICD-10-CM	A70-A74
Is cancer (heuristic)	no

Also known as: Chlamydia caused disease or disorder · Chlamydia disease or disorder · Chlamydia infection · Chlamydia infectious disease · chlamydia infectious disease · Chlamydophila caused disease or disorder · Chlamydophila disease or disorder · infection, Chlamydia · infections, Chlamydia

Data availability: 6 GWAS associations (1 study).

Disease family

This is a subtype of bacterial sexually transmitted disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › bacterial sexually transmitted disease › chlamydia infectious disease

Related subtypes (4): chancroid, gonorrhea, granuloma inguinale, Treponema infectious disease

Subtypes (1): chlamydia trachomatis infectious disease

Genetics & variants

GWAS landscape

6 GWAS associations across 1 studies. Top hits map to 5 distinct genes (as reported by GWAS).

Top associations by p-value

rsID	p-value	Gene	Risk allele	Odds ratio
rs9304095	6e-07	DSG4, DSG1-AS1	A	0.35
rs12758717	1e-06	UBE2U - RNU7-62P	T	0.38
rs62191602	5e-06	EFHD1	C	3.89
rs12542681	5e-06	BMP1	C	2.39
rs4326932	6e-06	OBI1-AS1	T	2.3
rs322736	7e-06	SND1 - MIR129-1	A	0.33

Top studies (by case count)

Study	Lead author	Year	Cases	Controls	Title
GCST90044915	Zheng X	2021	74	0	Host Genetic Risk Factors for Chlamydia trachomatis-Related Infertility in Women.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

Tier	Variants
Tier 1: coding	0
Tier 2: splice/UTR	0
Tier 3: regulatory	0
Tier 4: intronic/intergenic	6

MAF distribution

Bucket	Variants
common (>=0.05)	6
low_freq (0.01-0.05)	0
rare (<0.01)	0
unknown	0

Functional consequences

Consequence	Count
intron_variant	4
intergenic_variant	2

Top variants

rsID	Chr	Pos	Alleles	MAF	Consequence	Gene	p-value	Tier
rs9304095	18	31395169	A>C,G,T	0.05	intron_variant	DSG4, DSG1-AS1	6e-07	Tier 4: intronic/intergenic
rs12758717	1	64373865	T>A,C	0.05	intron_variant	UBE2U - RNU7-62P	1e-06	Tier 4: intronic/intergenic
rs62191602	2	232613757	C>T	0.05	intergenic_variant	EFHD1	5e-06	Tier 4: intronic/intergenic
rs12542681	8	22166244	G>A,C,T	0.05	intron_variant	BMP1	5e-06	Tier 4: intronic/intergenic
rs4326932	13	78451335	T>A,C,G	0.05	intron_variant	OBI1-AS1	6e-06	Tier 4: intronic/intergenic
rs322736	7	128146046	A>C,G,T	0.05	intergenic_variant	SND1 - MIR129-1	7e-06	Tier 4: intronic/intergenic

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 24.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	17
PHASE3	4
PHASE1/PHASE2	2
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00000120	PHASE3	COMPLETED	Clinical Trial of Eye Prophylaxis in the Newborn
NCT00112255	PHASE3	COMPLETED	Partner Notification for Chlamydia in Primary Care
NCT00120770	PHASE3	TERMINATED	Cellulose Sulfate (CS) Gel and HIV in Nigeria
NCT00124878	PHASE3	UNKNOWN	Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community
NCT00001890	PHASE2	COMPLETED	Effects of Hormone Therapy on the Immune Systems of Postmenopausal Women With Chronic Infections
NCT00207493	PHASE1/PHASE2	COMPLETED	The Participant Agreement for Contact Tracing (PACT) Study: Enhancing Partner Notification Services.
NCT00207506	PHASE1/PHASE2	COMPLETED	Lay Health Advisors for Sexually Transmitted Disease Prevention
NCT07500415	Not specified	RECRUITING	Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de Janeiro
NCT00005496	Not specified	COMPLETED	Inflammation, Infection, and Future Cardiovascular Risk
NCT00005547	Not specified	COMPLETED	Infection and Cardiovascular Disease
NCT00037388	Not specified	COMPLETED	Pediatrics:Chlamydia, Sickle Cell Anemia and Stroke Risk - Ancillary to STOP II
NCT00091728	Not specified	TERMINATED	Hormonal Contraception and Risk of Chlamydia and Gonorrhea
NCT00115388	Not specified	COMPLETED	Community-Based Trial of Screening for Chlamydia Trachomatis to Prevent Pelvic Inflammatory Disease
NCT00132457	Not specified	COMPLETED	Use of Self-collected Vaginal Swabs as an Innovative Approach to Facilitate Testing for Repeat Chlamydia Infection
NCT00252096	Not specified	COMPLETED	Nucleic Acid Amplification Tests (NAATs) for the Diagnosis of Pharyngeal and Rectal Chlamydia and Gonorrhea Infections
NCT00381992	Not specified	COMPLETED	Risk Assessment of Long-Haul Truck Drivers
NCT00561028	Not specified	COMPLETED	Chlamydia and Mycoplasma in Coronary Artery Disease
NCT00578188	Not specified	WITHDRAWN	Chlamydia Trachomatis Persistence in the Female Gastrointestinal Tract
NCT01291264	Not specified	TERMINATED	Use of Abbott RealTime CT/NG to Detect Chlamydia Trachomatis [CT] & Neisseria Gonorrhoeae [NG] in Men Who Have Sex With Men [MSM]
NCT01638637	Not specified	COMPLETED	Prospective Collection of Female and Male Specimens for PANTHER® System Testing
NCT01728103	Not specified	TERMINATED	Prospective Collection of Female Specimens for Testing With Gen-Probe APTIMA (Registered Trademark) Assays
NCT03073538	Not specified	COMPLETED	Screening of Gonococcal and Chlamydial Infections in the Third Trimester
NCT03374696	Not specified	COMPLETED	Theater in School Sex Education - a Randomized Controlled Study
NCT05727033	Not specified	UNKNOWN	Extraordinarily Fun Training Project in Compulsory Secondary Education - Sexually Transmitted Infections

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ERYTHROMYCIN	4	1
ESTRADIOL	4	1
ESTROGEN	3	1
POWDERED CELLULOSE	3	1