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Atlas / Disease / Cholangitis

Cholangitis

disease
On this page

Also known as biliary tract infectionbiliary tree inflammationinflammation of biliary tree

Summary

Cholangitis (MONDO:0004789) is a disease (an umbrella term covering 9 Mondo subtypes) and 45 clinical trials. Top therapeutic interventions include ursodiol, ceftriaxone, and gentamicin. A subtype of non-neoplastic bile duct disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Umbrella term: 9 Mondo subtypes
  • Clinical trials: 45

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical namecholangitis
Mondo IDMONDO:0004789
MeSHD002761
DOIDDOID:9446
ICD-10-CMK83.0
ICD-111712178777
NCITC26718
SNOMED CT82403002
UMLSC0008311
MedGen40258
Is cancer (heuristic)no

Also known as: biliary tract infection · biliary tree inflammation · cholangitis · inflammation of biliary tree

Disease family

This is a subtype of non-neoplastic bile duct disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › hepatobiliary disorder › biliary tract disorder › bile duct disorder › non-neoplastic bile duct disorder › cholangitis

Related subtypes (4): extrahepatic cholestasis, obstructive jaundice, biliary atresia, Caroli disease

Subtypes (9): suppurative cholangitis, ascending cholangitis, acute cholangitis, pericholangitis, cholecystitis, chronic cholangitis, sclerosing cholangitis, primary biliary cholangitis/primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome, autoimmune cholangitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

2 approved. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

DrugDevelopment status
ElafibranorApproved (phase 4)
Obeticholic AcidApproved (phase 4)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Ceftriaxone, Moxifloxacin.

Clinical trials & evidence

Clinical trials

Clinical trials: 45.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified33
PHASE28
PHASE43
PHASE31

Top trials by phase / activity

NCTPhaseStatusTitle
NCT01744847PHASE4COMPLETEDDGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study
NCT02034279PHASE4TERMINATEDThe INFECIR-2 Albumin Prevention Study
NCT03087656PHASE4UNKNOWNAntibiotics to Decrease Post ERCP Cholangitis
NCT03716232PHASE3UNKNOWNKaffes Stent in the Management of Post-surgical Biliary Strictures
NCT07407491PHASE2RECRUITINGComparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis
NCT07509346PHASE2NOT_YET_RECRUITINGFecal Microbiota Transplant vs Standard Treatment for Recurrent Non-Obstructive Cholangitis
NCT02098486PHASE2COMPLETEDComparisons of Intravenous Ceftriaxone With Intravenous Moxifloxacin in ERCP
NCT02618668PHASE2TERMINATEDHaemodynamic Stability of Ketamine/Propofol Admixture Ketofol in Patient Undergoing Endoscopic Retrograde Cholangio Pancreatography
NCT03678480PHASE2WITHDRAWNA Study of HTD1801 in Adolescents With Primary Sclerosing Cholangitis (PSC)
NCT04604652PHASE2COMPLETEDOpen-Label Study of HTD1801 in Adult Subjects With Primary Biliary Cholangitis
NCT04612413PHASE2COMPLETEDA Phase 2 Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients
NCT06111872PHASE2COMPLETEDKetamine-midazolam as a Sedative Agent in Endoscopic Retrograde Cholangiopancreatography.
NCT03104569Not specifiedNOT_YET_RECRUITINGEffect of 37℃ Non-ionic Contrast Agent During ERCP Procedure in Hilar Cholangiocarcinoma
NCT05061680Not specifiedRECRUITINGQuick Large Balloon Dilatation for Removal of Large Bile Duct Stones (SHODBADI)
NCT05750966Not specifiedACTIVE_NOT_RECRUITINGShort-course Antibiotics vs Standard Course Antibiotics in Patients With Cholangitis
NCT05925309Not specifiedRECRUITINGPreventive Effect of Prophylactic Oral Antibiotics Against Cholangitis After Kasai Portoenterostomy
NCT07129655Not specifiedNOT_YET_RECRUITINGCholangitis Definition and Treatment After Kasai Hepatoportoenterostomy for Biliary Atresia: TRACK-BA Study (TRacking Cholangitis Post Kasai in Biliary Atresia)
NCT00591968Not specifiedCOMPLETEDTelesonography Adaptation and Use to Improve the Standard of Patient Care Within a Dominican Community
NCT00990366Not specifiedTERMINATEDTreatment of Biliary Obstruction Using Biliary Stent With or Without Antireflux Valve
NCT01003782Not specifiedCOMPLETEDRoutine Bile Collection for Microbiological Analysis During Cholangiography
NCT01109550Not specifiedCOMPLETEDBiliary Candidiasis - Optimization of Diagnostics and Therapy
NCT01142921Not specifiedTERMINATEDThe Patency Period of the New Plastic Anti-reflux Biliary Stent
NCT01148693Not specifiedCOMPLETEDGentamicin in Preventing Post Endoscopic Retrograde Cholangiopancreatography (ERCP) Cholangitis in Non-calculus Stenting
NCT01438385Not specifiedUNKNOWNInterventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders
NCT01824186Not specifiedCOMPLETEDTrial Comparing Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy
NCT02107560Not specifiedTERMINATEDResults of Bile and Blood Culture in Patients With Acute Cholangitis
NCT02461147Not specifiedCOMPLETEDProspective Validation of Cholecystectomy First Strategy for Gallstone Migration
NCT02543957Not specifiedWITHDRAWNFactors Associated With Increased Risk of Bacteremia and Cholangitis in ERCP With Cholangioscopy
NCT02594891Not specifiedCOMPLETEDEffect of 8.5 F Plastic Stent Without Proximal Flap on Prevention of Post-ERCP Cholangitis
NCT02917408Not specifiedCOMPLETEDRetrospective Study About Primary Biliary Cholangitis During January 2001 to July 2016 at West China Hospital
NCT02936596Not specifiedUNKNOWNRemission Induction of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome
NCT03104582Not specifiedCOMPLETEDBest Biliary Drainage Option in Advanced Klatskin Tumor
NCT03133026Not specifiedUNKNOWNCholangioscopic Assessment of Occluded Biliary Stent and Role of Biliary Radiofrequency Ablation
NCT03771547Not specifiedCOMPLETEDERCP in Super-aged Patients Considering Difficult Cannulation: Challenges and Adverse Events
NCT03852836Not specifiedTERMINATEDEvaluation of MRI Sequences for Ultra-rapid Acquisition of Bile Ducts Images
NCT04216745Not specifiedUNKNOWNMicrobial Analysis in Patients With Cholangitis
NCT04671095Not specifiedCOMPLETEDSingle Use ERCP Performance -SURE Study
NCT04691674Not specifiedCOMPLETEDOptimal Placement Duration of Pancreatic Duct Stent
NCT04801238Not specifiedUNKNOWNpreGallstep - A Clinical Pilot Trial
NCT05225909Not specifiedCOMPLETEDaScope Single Use ERCP Study- ASSURE Study

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
URSODIOL46
CEFTRIAXONE42
GENTAMICIN42
LEVOFLOXACIN ANHYDROUS42
ALBUMIN HUMAN41
CEFUROXIME41
OFLOXACIN41
BERBERINE URSODEOXYCHOLATE22
CHEMBL540958303
CHEMBL19589202
CHEMBL303959702
GENTAMICIN C1A02
GENTAMICIN C202

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 22

This page pulls from 22 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogenccgwasgwas_studyhgncicd10cmicd11medgenmeshmimmondomondochildmondoparentncitorphanetsctidumls