Cholecystitis

Summary

Cholecystitis (MONDO:0002155) is a disease and 192 clinical trials. Top therapeutic interventions include indocyanine green acid form, dexmedetomidine, and ondansetron. A subtype of cholangitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 192

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	cholecystitis
Mondo ID	MONDO:0002155
MeSH	D002764
DOID	DOID:1949
ICD-10-CM	K81
ICD-11	786251500
NCIT	C34465
SNOMED CT	20824003
UMLS	C0008325
MedGen	920
Is cancer (heuristic)	no

Also known as: acalculous cholecystitis · acute and chronic cholecystitis · acute cholecystitis · acute on chronic cholecystitis · chronic cholecystitis · gall bladder inflammation · gallstone cholecystitis · inflammation of gall bladder

Disease family

This is a subtype of cholangitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › hepatobiliary disorder › biliary tract disorder › bile duct disorder › non-neoplastic bile duct disorder › cholangitis › cholecystitis

Related subtypes (8): suppurative cholangitis, ascending cholangitis, acute cholangitis, pericholangitis, chronic cholangitis, sclerosing cholangitis, primary biliary cholangitis/primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome, autoimmune cholangitis

Subtypes (4): xanthogranulomatous cholecystitis, emphysematous cholecystitis, acalculous cholecystitis, acute cholecystitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 3 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Amoxicillin	Phase 3 (in late-stage trials)
Clavulanic Acid	Phase 3 (in late-stage trials)
Doripenem	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Ondansetron, Sodium Chloride.

Clinical trials & evidence

Clinical trials

Clinical trials: 192.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	160
PHASE4	11
PHASE1	7
PHASE3	6
PHASE2/PHASE3	5
PHASE2	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00195351	PHASE4	COMPLETED	Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection
NCT00230971	PHASE4	COMPLETED	Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI)
NCT01744847	PHASE4	COMPLETED	DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study
NCT01833819	PHASE4	COMPLETED	Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy
NCT02056678	PHASE4	WITHDRAWN	Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA
NCT02057679	PHASE4	COMPLETED	Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis
NCT02493231	PHASE4	UNKNOWN	Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia
NCT02812186	PHASE4	COMPLETED	Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery
NCT04624841	PHASE4	UNKNOWN	Indocyanine Green to Visualize Critical View of Safety During Laparoscopic Cholecystectomy for Acute Cholecystitis
NCT05709548	PHASE4	UNKNOWN	Use of Indocyanine Green in Acute Cholecystitis
NCT06927817	PHASE4	COMPLETED	The Effect of Hyoscine-n-butylbromide on Nausea and Pain in Laparoscopic Cholecystectomy
NCT05893511	PHASE3	RECRUITING	EUS-GBD vs Antibiotics for Patients at High Risk for Cholecystectomy
NCT06740903	PHASE2/PHASE3	RECRUITING	Evaluating Perioperative Outcomes: Dexmedetomidine vs Lignocaine in Laparoscopic Chlolecystectomy
NCT07595003	PHASE3	RECRUITING	Efficacy, Safety, and Tolerability of 4-MUST, 128 mg Tablets in Chronic Cholecystitis and Biliary Dyskinesia
NCT00210938	PHASE3	COMPLETED	Doripenem in the Treatment of Complicated Intra-Abdominal Infections
NCT00229060	PHASE3	COMPLETED	Doripenem in the Treatment of Complicated Intra-Abdominal Infections
NCT00370344	PHASE2/PHASE3	COMPLETED	Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease
NCT00447304	PHASE3	COMPLETED	Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy
NCT00904865	PHASE2/PHASE3	UNKNOWN	Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy
NCT01625247	PHASE3	UNKNOWN	Drainage is Not Necessary Procedure After Laparoscopic Cholecystectomy Due to Severe Acute Cholecystitis
NCT02212717	PHASE2/PHASE3	COMPLETED	A Randomized Controlled Trial on EGBD vs PC for Acute Cholecystitis.
NCT04808544	PHASE2/PHASE3	COMPLETED	Naldebain for Pain Management of Laparoscopic Cholecystectomy
NCT06842966	PHASE2	RECRUITING	Efficacy, Safety, and Tolerability of 4-MUST Tablets in Chronic Cholecystitis and Biliary Dyskinesia
NCT04468685	PHASE2	COMPLETED	Ondansetron Effect on Pain Relief After Laparoscopic Cholecystectomy
NCT04942665	PHASE2	COMPLETED	Low Dose ICG for Biliary Tract and Tumor Imaging
NCT07594977	PHASE1	RECRUITING	Food-Effect, Single and Multiple Dose Pharmacokinetics, Safety and Tolerability Study of 4-MUST, 128 mg, Tablets in Healthy Volunteers
NCT00815438	PHASE1	WITHDRAWN	Transvaginal Cholecystectomy Using Endoscopic Assistance
NCT02070627	PHASE1	COMPLETED	Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy – Use in Acute Cholecystitis Sub-Study
NCT04726046	PHASE1	COMPLETED	Effectiveness of Prophylactic Antibiotics Therapy in Laparoscopic Cholecystectomy on Infection Rate
NCT05006950	PHASE1	TERMINATED	SPY Fluorescence Imaging Systems and Indocyanine Green to Determine the Percentage of Successful Critical Anatomy Recognition in Laparoscopic Cholecystectomy Surgeries.
NCT06315387	PHASE1	UNKNOWN	Safety, Tolerability and Pharmacokinetics of 4-MUST, Tablets, 128 mg (Valenta Pharm JSC) During Single and Multiple Oral Administration in Healthy Volunteers
NCT06342804	PHASE1	UNKNOWN	Food Effect on the Bioavailability of 4-MUST, Tablets, 128 mg
NCT03643718	Not specified	RECRUITING	Web-based International Register of Emergency Surgery and Trauma
NCT04033822	Not specified	ACTIVE_NOT_RECRUITING	Fast Track Pathway to Accelerated Cholecystectomy
NCT04813055	Not specified	RECRUITING	Prospective Registry Of Therapeutic EndoscopiC ulTrasound
NCT05732480	Not specified	RECRUITING	Influence of Gut Microbiome in Gallstone Disease
NCT06123117	Not specified	RECRUITING	STALL vs Sole Local Wound Infiltration in Laparoscopic Cholecystectomy
NCT06228027	Not specified	NOT_YET_RECRUITING	External Validation os the ACME Scoring System
NCT06287112	Not specified	RECRUITING	Prevention of Acute Cholecystitis With ETGBD
NCT06330688	Not specified	RECRUITING	Prospective Evaluation of Ultrasound-guided Percutaneous Cholecystostomy With the Trocar Technique

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
INDOCYANINE GREEN ACID FORM	4	6
DEXMEDETOMIDINE	4	3
ONDANSETRON	4	3
DORIPENEM	4	2
TIGECYCLINE	4	2
ACETAMINOPHEN	4	1
AMOXICILLIN	4	1
CEFOTETAN	4	1
CEFTOLOZANE	4	1
CEFTRIAXONE	4	1
DESFLURANE	4	1
KETAMINE	4	1
LIDOCAINE	4	1
MOXIFLOXACIN	4	1
NEFOPAM	4	1
REMIFENTANIL	4	1
REMIMAZOLAM	4	1
ROCURONIUM	4	1
SULBACTAM	4	1
CEPHALOSPORIN	3	1
MEDETOMIDINE	3	1
DINALBUPHINE SEBACATE	2	1
CHEMBL4067090	0	1
CEPHALOSPORIN C	-1	1