Cholecystolithiasis
diseaseOn this page
Summary
Cholecystolithiasis (MONDO:0006698) is a disease and 41 clinical trials. Top therapeutic interventions include ursodiol, droperidol, and esketamine. A subtype of gallbladder disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 41
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | cholecystolithiasis |
| Mondo ID | MONDO:0006698 |
| EFO | EFO:1000864 |
| MeSH | D041761 |
| DOID | DOID:11151 |
| UMLS | C0947622 |
| MedGen | 215268 |
| MedDRA | 10049890 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of gallbladder disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › hepatobiliary disorder › gallbladder disorder › cholecystolithiasis
Related subtypes (10): cholesterolosis of gallbladder, cholecystitis, occlusion of gallbladder, hydrops of gallbladder, biliary dyskinesia, gallbladder neoplasm, polyp of gallbladder, Rokitansky-Aschoff sinuses of the gallbladder, hereditary gallbladder disorder, gallbladder duplication
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 41.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 34 |
| PHASE4 | 6 |
| PHASE2/PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00161083 | PHASE4 | COMPLETED | UDCA for Symptomatic Gallstone Disease |
| NCT00209885 | PHASE4 | UNKNOWN | Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy |
| NCT00562900 | PHASE4 | COMPLETED | Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study |
| NCT01199406 | PHASE4 | COMPLETED | Pain Reduction After Cholecystectomy |
| NCT02114437 | PHASE4 | UNKNOWN | Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy |
| NCT02116985 | PHASE4 | COMPLETED | Dual-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy (DLTCI) |
| NCT00370344 | PHASE2/PHASE3 | COMPLETED | Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease |
| NCT03812718 | Not specified | RECRUITING | Comparison of Anaesthesia Requirement for Ventilation With Endotracheal Tube Versus Proseal Laryngeal Mask Airway |
| NCT06045546 | Not specified | ACTIVE_NOT_RECRUITING | A (5-5-5-8) Technique for Laparoscopic Cholecystectomy |
| NCT07002619 | Not specified | RECRUITING | ChOlanGiography Performed Routinely Versus Selectively During Cholecystectomy: A NAtional Registry-based Randomized Controlled Trial |
| NCT07245108 | Not specified | RECRUITING | The Pro-Chol Study |
| NCT00940264 | Not specified | COMPLETED | Laparoscopic Transvaginal Hybrid Cholecystectomy: a Prospective Data Collection. |
| NCT00974194 | Not specified | COMPLETED | Safety and Cost-effectiveness Study of Single Port Laparoscopic Cholecystectomies |
| NCT01047085 | Not specified | COMPLETED | Does Cholecystectomy Increase the Esophageal Alkaline Reflux? Evaluation by Impedance-pH Technique |
| NCT01056250 | Not specified | COMPLETED | SILS Cholecystectomy: Cholangiography of the Biliary Tract |
| NCT01289379 | Not specified | COMPLETED | The Effect of High Frequency Jet Ventilation (HFJV)During Laparoscopic Operations |
| NCT01552421 | Not specified | TERMINATED | The Effect of Transvaginal vs. Conventional Laparoscopic Cholecystectomy on the Postoperative Course |
| NCT01553331 | Not specified | COMPLETED | Day Case Laparoscopic Cholecystectomy: Fundus First With Ultrasonic Dissection or Conventional Diathermy Hook |
| NCT01615549 | Not specified | UNKNOWN | Efficacy of Proficiency-based Versus Free Laparoscopic Training in Cholecystectomy on a Virtual Reality Simulator |
| NCT01667848 | Not specified | COMPLETED | Warmed, Humidified Carbon Dioxide Insufflation vs Standard Carbon Dioxide in Laparoscopic Cholecystectomy |
| NCT01740973 | Not specified | COMPLETED | Risk of Umbilical Trocar-site Hernia After SILC Cholecystectomy Versus Conventional Cholecystectomy |
| NCT01824186 | Not specified | COMPLETED | Trial Comparing Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy |
| NCT02357589 | Not specified | COMPLETED | 3D vs 2D HD Laparoscopy in Cholecystectomy |
| NCT02554097 | Not specified | UNKNOWN | Chinese Registry Study on Treatment of Cholecysto-Choledocholithiasis |
| NCT02558556 | Not specified | UNKNOWN | FALCON: a Multicenter Randomized Controlled Trial |
| NCT02752698 | Not specified | UNKNOWN | Domestic Surgical Robot Clinical Study |
| NCT03154164 | Not specified | COMPLETED | Study on the Learning Curve for Fundus First With Ultrasonic Tissue Coagulation in Elective Cholecystectomy |
| NCT03909360 | Not specified | UNKNOWN | Drainage or Not for Laparoscopic Cholecystetomy |
| NCT04052633 | Not specified | COMPLETED | Success of Intraoperative Cholangiography |
| NCT04142203 | Not specified | COMPLETED | Implementation of 23 Hour Surgery Model in a Tertiary Hospital |
| NCT04737642 | Not specified | COMPLETED | Feasibility and Safety of Bile Duct Clearance by Transcystic Sphincter of Oddi Balloon Dilatation |
| NCT04922528 | Not specified | UNKNOWN | Visualization of the Extrahepatic biliaRy Tree Trial |
| NCT05280860 | Not specified | UNKNOWN | Effect of Bilateral RSB on Postoperative Delirium in Elderly Patients Undergoing Laparoendoscopic Single-site Surgery |
| NCT05723224 | Not specified | UNKNOWN | Elective Endoscopic Gallbladder Treatment: Pilot Study |
| NCT05827445 | Not specified | COMPLETED | Cutaneous Sensory Block Area of the Laparoscopic Assisted Transversus Abdominis Plane Block |
| NCT05962853 | Not specified | COMPLETED | Effect of TENS on Patient Outcomes After Laparoscopic Cholecystectomy |
| NCT06035302 | Not specified | UNKNOWN | Madany Closure: A Novel Technique for Fascial Closure in Laparoscopic Surgery |
| NCT06036303 | Not specified | UNKNOWN | Nasr Fascial Closure: A Novel Device for Fascial Closure in Laparoscopic Surgery |
| NCT06672991 | Not specified | COMPLETED | ERCP and LC for Cholecystocholedocholithiasis in Children: Should It Be Accomplished in One or Repeated Hospitalization? |
| NCT06676241 | Not specified | COMPLETED | One-stage and Delayed Laparoscopic Cholecystectomy After Endoscopic Retrograde Cholangiopancreatography with Endoscopic Sphincterotomy in Cholecystocholedocholithiasis |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| URSODIOL | 4 | 2 |
| DROPERIDOL | 4 | 1 |
| ESKETAMINE | 4 | 1 |
| GABAPENTIN | 4 | 1 |
| LEVOBUPIVACAINE | 4 | 1 |
| LIDOCAINE | 4 | 1 |
| CHEMBL5409583 | 0 | 1 |
Related Atlas pages
- Drugs: Ursodiol, Droperidol, Esketamine, Gabapentin, Levobupivacaine, Lidocaine