Choledocholithiasis
diseaseOn this page
Summary
Choledocholithiasis (MONDO:0006699) is a disease and 82 clinical trials. Top therapeutic interventions include midazolam, etomidate, and meperidine. A subtype of common bile duct disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 82
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | choledocholithiasis |
| Mondo ID | MONDO:0006699 |
| EFO | EFO:1000865 |
| MeSH | D042883 |
| DOID | DOID:11755 |
| UMLS | C0701818 |
| MedGen | 148784 |
| MedDRA | 10049891 |
| Anatomy (UBERON) | UBERON:0001174 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of common bile duct disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › hepatobiliary disorder › biliary tract disorder › bile duct disorder › common bile duct disorder › choledocholithiasis
Related subtypes (2): biliary dyskinesia, common bile duct neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 82.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 75 |
| PHASE4 | 4 |
| PHASE2 | 2 |
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT07418112 | PHASE4 | RECRUITING | Comparing the Efficacy and Safety of Holmium Laser Lithotripsy Versus Electrohydraulic Lithotripsy for the Treatment of Difficult Choledocholithiasis and Pancreatic Duct Stones |
| NCT02027311 | PHASE4 | COMPLETED | Etomidate vs. Midazolam for Sedation During ERCP |
| NCT02703077 | PHASE4 | UNKNOWN | Endoscopic Treatment of Difficult Bile Duct Stones: Spyglass + EHL x Balloon Dilation of the Papilla |
| NCT04484870 | PHASE4 | COMPLETED | Danshu Capsule and Ursodeoxycholic Acid Capsule in Preventing Recurrence of Choledocholithiasis |
| NCT02592811 | PHASE3 | COMPLETED | Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones |
| NCT07407491 | PHASE2 | RECRUITING | Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis |
| NCT06111872 | PHASE2 | COMPLETED | Ketamine-midazolam as a Sedative Agent in Endoscopic Retrograde Cholangiopancreatography. |
| NCT03921502 | Not specified | RECRUITING | Clinical Trial Comparing ERCP vs ERCP and Transmural Gall Bladder Drainage |
| NCT05141916 | Not specified | RECRUITING | Optimizing the Evaluation and Management of Patients With Suspected Choledocholithiasis |
| NCT05210322 | Not specified | ACTIVE_NOT_RECRUITING | Percutaneous Cholangiopancreatoscopy Registry |
| NCT06066372 | Not specified | RECRUITING | Application of Machine Learning Models to Reduce Need for Diagnostic EUS or MRCP in Patients With Intermediate Likelihood of Choledocholithiasis |
| NCT06215040 | Not specified | RECRUITING | The Treatment Effect for Asymptomatic Common Bile Duct Stone |
| NCT06670547 | Not specified | NOT_YET_RECRUITING | Spanish Registry of Quality Indicators and Adverse Events of Endoscopic Retrograde Cholangiopancreatography |
| NCT06852937 | Not specified | RECRUITING | Using da Vinci SP System for Patients With Cholelithiasis and Choledocholithiasis |
| NCT07001423 | Not specified | RECRUITING | ChOlecystectomy aFter successFul Endoscopic Common Bile Duct Stone Extraction in Elderly |
| NCT07008170 | Not specified | RECRUITING | Laparoendoscopic Rendezvous for Concomitant Gall Bladder Stones and Common Bile Duct Stones |
| NCT07064447 | Not specified | NOT_YET_RECRUITING | Spanish Registry of Direct Cholangiopancreatoscopy by Single Operator |
| NCT07130864 | Not specified | RECRUITING | Early vs Late Laparoscopic Cholecystectomy After Common Bile Duct Stones Clearance Through Ercp. |
| NCT07283185 | Not specified | RECRUITING | Prospective Comparison of the Carbon Footprint of EUS vs MRCP for Evaluation of Suspected Choledocholithiasis |
| NCT07329803 | Not specified | NOT_YET_RECRUITING | Pre-cut Versus Intentional Double Guidewire for ERCP Cannulation: Prospective, Randomized Controlled Trial |
| NCT07503964 | Not specified | ACTIVE_NOT_RECRUITING | The Significance of Laparoscopic Transcystic Papilla Vateri Balloon Dilatation in Patients With Choledocholithiasis. |
| NCT00124033 | Not specified | TERMINATED | Management of Common Bile Duct (CBD) Stones at Laparoscopic Cholecystectomy |
| NCT00173368 | Not specified | COMPLETED | Study of Endoscopic Sphincterotomy With Needle Knife Papillotome in Patients of Ampullary Impacted Stone |
| NCT00329888 | Not specified | UNKNOWN | Comparison of Papillary Balloon Dilatation Vs.Sphincterotomy for Lithotripsy in Difficult Sphincterotomy or Distal CBD Tapering |
| NCT00416234 | Not specified | UNKNOWN | Laparoendoscopic Rendez Vous Versus Standard Two Stage Approach for the Management of Cholelithiasis/Choledocholithiasis |
| NCT00451581 | Not specified | UNKNOWN | A Prospective Randomized Study Comparing Different Dilation Durations for Endoscopic Papillary Balloon Dilatation |
| NCT00612846 | Not specified | TERMINATED | Study Investigating the Best Method of Treatment of Bile Duct Stones in Higher Risk Patients |
| NCT01414400 | Not specified | COMPLETED | Prospective Study to Investigate the Frequency of Possible Bacterial Entry Into the Bloodstream (Bacteremia) and Infectious Complications Associated With the Use of the Spyglass Cholangioscopy System During ERCP (Endoscopic Retrograde Cholangiopancreatography). |
| NCT01438385 | Not specified | UNKNOWN | Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders |
| NCT01475864 | Not specified | WITHDRAWN | Prospective Evaluation of the Covered Self-expandable Metal Stents (CSEMS) for Incomplete Biliary Stone Clearance |
| NCT01673269 | Not specified | COMPLETED | Prospective Study of the Risk of Bacteremia in Directed Cholangioscopic Examination of the CBD |
| NCT01683240 | Not specified | COMPLETED | Prospective Multicenter Evaluation of a New Short-access-cholangioscope for Biliary Duct Strictures and Gall Stones |
| NCT01759979 | Not specified | COMPLETED | Laser Versus Mechanical Lithotripsy of Bile Duct Stones |
| NCT01824186 | Not specified | COMPLETED | Trial Comparing Pain in Single-incision Laparoscopic Cholecystectomy Versus Conventional Laparoscopic Cholecystectomy |
| NCT02028845 | Not specified | COMPLETED | Loop-tipped Guidewire in Selective Biliary Cannulation |
| NCT02037958 | Not specified | COMPLETED | Laryngeal Mask Airway Supreme Versus the Tracheal Tube as an Airway Device in Elective Laparoscopic Cholecystectomy |
| NCT02276157 | Not specified | COMPLETED | Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope |
| NCT02461147 | Not specified | COMPLETED | Prospective Validation of Cholecystectomy First Strategy for Gallstone Migration |
| NCT02515474 | Not specified | COMPLETED | Comparison of LCBDE vs ERCP + LC for Choledocholithiasis |
| NCT02554097 | Not specified | UNKNOWN | Chinese Registry Study on Treatment of Cholecysto-Choledocholithiasis |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| MIDAZOLAM | 4 | 2 |
| ETOMIDATE | 4 | 1 |
| MEPERIDINE | 4 | 1 |
| S-ETOMIDATE | -1 | 1 |
Related Atlas pages
- Drugs: Midazolam, Etomidate, Meperidine