Chondrocalcinosis

Summary

Chondrocalcinosis (MONDO:0001314) is a disease and 10 clinical trials. Top therapeutic interventions include hydroxychloroquine and probenecid. A subtype of metabolic disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 10

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	chondrocalcinosis
Mondo ID	MONDO:0001314
MeSH	D002805
DOID	DOID:1156
ICD-11	2041797033
NCIT	C34955
SNOMED CT	239832006
UMLS	C0553730
MedGen	154303
Is cancer (heuristic)	no

Also known as: calcium pyrophosphate deposition disease · pseudogout

Data availability: 1 HPO phenotype.

Disease family

This is a subtype of metabolic disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › metabolic disease › chondrocalcinosis

Related subtypes (36): glutaric aciduria, mineral metabolism disease, xanthinuria, ochronosis disorder, glucose metabolism disease, diabetic kidney disease, xanthoma, diabetic retinopathy, hypertriglyceridemia, gout, lactic acidosis, acquired metabolic disease, lipodystrophy, developmental anomaly of metabolic origin, dopa-responsive dystonia, hypoalphalipoproteinemia, steroid dehydrogenase deficiency-dental anomalies syndrome, inborn errors of metabolism, vitamin B12 deficiency, proteostasis deficiencies, hyperlipidemia, disorder of GPI anchor biosynthesis, bilirubin metabolism disease, hyperlipoproteinemia, carbohydrate metabolism disease, porphyrin metabolism disease, purine metabolism disease, amino acid metabolism disease, pyrimidine metabolism disease, disorder of acid-base balance, disorder of glutamate decarboxylase, tumor lysis syndrome, collagenous sprue, steroid metabolism disease, disorder of organic acid metabolism, skeletal fluorosis

Subtypes (3): chondrocalcinosis 2, chondrocalcinosis due to apatite crystal deposition, chondrocalcinosis 1

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 10.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE2	2
PHASE3	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03128905	PHASE3	COMPLETED	Trial of Colchicine Versus Prednisone for the Treatment of Acute CPPD Arthritis
NCT06768294	PHASE2	NOT_YET_RECRUITING	Baricitinib in CPPD - the BAPTIST Study
NCT07254637	PHASE2	NOT_YET_RECRUITING	Tocilizumab in Chronic Inflammatory CPPD Disease
NCT02243631	EARLY_PHASE1	COMPLETED	Effect of Probenecid on Synovial Fluid ATP Levels in CPPD
NCT04695028	Not specified	RECRUITING	CRYSTALILLE Cohort: Getting the Whole Picture of Crystal-related Arthropathies
NCT07005804	Not specified	NOT_YET_RECRUITING	Calcium Pyrophosphate Deposition (CPPD) Disease
NCT00453128	Not specified	COMPLETED	Diagnostic Rentability of Screening for Associated Conditions in Calcium Pyrophosphate Deposition Disease Patients
NCT00797537	Not specified	COMPLETED	Ultrasound and X-ray in Detecting Articular Cartilage Calcification
NCT01642706	Not specified	UNKNOWN	Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments
NCT01867840	Not specified	UNKNOWN	Role of ASICs in Human Inflammatory Pain

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
HYDROXYCHLOROQUINE	4	1
PROBENECID	4	1