Choriocarcinoma of testis

Summary

Choriocarcinoma of testis (MONDO:0003508) is a disease and 14 clinical trials. Top therapeutic interventions include dactinomycin, etoposide phosphate, and ifosfamide. A subtype of testicular trophoblastic tumor — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 14

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	choriocarcinoma of testis
Mondo ID	MONDO:0003508
EFO	EFO:1000564
DOID	DOID:5551
ICD-11	1972827817
NCIT	C7733
UMLS	C0238449
MedGen	65969
GARD	0023537
Anatomy (UBERON)	UBERON:0000473
Is cancer (heuristic)	no

Also known as: choriocarcinoma · choriocarcinoma of testis · choriocarcinoma of the testis · testicular choriocarcinoma · testis choriocarcinoma (disease)

Data availability: 2 cell lines.

Disease family

An umbrella term covering 2 Mondo subtypes.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › trophoblastic neoplasm › testicular trophoblastic tumor › choriocarcinoma of testis

Subtypes (2): childhood testicular choriocarcinoma, testicular monophasic choriocarcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 2 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Cisplatin	Phase 3 (in late-stage trials)
Etoposide	Phase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 14.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE2	5
PHASE3	2
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02375204	PHASE3	ACTIVE_NOT_RECRUITING	Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients with Relapsed or Refractory Germ Cell Tumors
NCT01535053	PHASE3	COMPLETED	Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia
NCT04684368	PHASE2	RECRUITING	A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT
NCT00190918	PHASE2	COMPLETED	A Trial for Patients With Gestational Trophoblastic Disease
NCT00467051	PHASE2	COMPLETED	Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors
NCT02396511	PHASE2	COMPLETED	TRC105 Combined With Standard-dose Bevacizumab for Two Patients With Metastatic And Refractory Choriocarcinoma
NCT02664961	PHASE2	TERMINATED	Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)
NCT00060372	PHASE1	COMPLETED	Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer
NCT04562558	Not specified	ACTIVE_NOT_RECRUITING	Biweekly Actinomycin-D Treatment or Multi-day Methotrexate Protocol in Low-risk Gestational Trophoblastic Neoplasia
NCT05564026	Not specified	RECRUITING	Molecular Epidemiology of Pediatric Germ Cell Tumors
NCT00294177	Not specified	UNKNOWN	Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma
NCT01267851	Not specified	UNKNOWN	Clinical Database and Biobank of Patients With Gynecologic Neoplasms
NCT01434355	Not specified	COMPLETED	DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
NCT03426865	Not specified	COMPLETED	Role of Axumin PET Scan in Germ Cell Tumor

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DACTINOMYCIN	4	2
ETOPOSIDE PHOSPHATE	4	1
IFOSFAMIDE	4	1
LEUCOVORIN	4	1
CAROTUXIMAB	3	2
CHEMBL4748391	0	2