Choroid plexus cancer

Summary

Choroid plexus cancer (MONDO:0002681) is a cancer and 3 clinical trials. Top therapeutic interventions include onc-206. A subtype of vascular cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 3

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	choroid plexus cancer
Mondo ID	MONDO:0002681
EFO	EFO:0007206
DOID	DOID:3540
NCIT	C4533
UMLS	C0346289
MedGen	138053
GARD	0023212
Anatomy (UBERON)	UBERON:0001886
Is cancer (heuristic)	yes

Also known as: cancer of choroid plexus · choroid plexus cancer · choroid plexus neoplasm · malignant choroid plexus neoplasm · malignant choroid plexus neoplasms · malignant choroid plexus tumor · malignant choroid plexus tumors · malignant choroid plexus tumour · malignant choroid plexus tumours · malignant neoplasm of choroid plexus · malignant neoplasm of the choroid plexus · malignant tumor of choroid plexus · malignant tumor of the choroid plexus · malignant tumour of choroid plexus · malignant tumour of the choroid plexus · tumor of choroid plexus · tumour of choroid plexus · tumour of the choroid plexus

Disease family

This is a subtype of vascular cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › cardiovascular cancer › vascular cancer › choroid plexus cancer

Related subtypes (6): malignant jugulotympanic paraganglioma, adrenal cortex carcinoma, choroid cancer, epithelioid hemangioendothelioma, angiosarcoma, great vessel cancer

Subtypes (2): choroid plexus meningioma, choroid plexus carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE1	2
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04541082	PHASE1	RECRUITING	Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
NCT01975116	PHASE1	COMPLETED	p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors
NCT02162732	Not specified	COMPLETED	Molecular-Guided Therapy for Childhood Cancer

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ONC-206	1	1