Chronic apical periodontitis
diseaseOn this page
Also known as chronic periapical periodontitisperiapical periodontitis, chronic
Summary
Chronic apical periodontitis (MONDO:0001251) is a disease and 17 clinical trials. Top therapeutic interventions include acetylcysteine and calcium hydroxide. A subtype of periapical periodontitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 17
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | chronic apical periodontitis |
| Mondo ID | MONDO:0001251 |
| DOID | DOID:11269 |
| ICD-10-CM | K04.5 |
| ICD-11 | 1079140240 |
| SNOMED CT | 718052004 |
| UMLS | C0392492 |
| MedGen | 581135 |
| Is cancer (heuristic) | no |
Also known as: chronic periapical periodontitis · periapical periodontitis, chronic
Disease family
This is a subtype of periapical periodontitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › periodontal disorder › periodontitis › periapical periodontitis › chronic apical periodontitis
Related subtypes (3): acute apical periodontitis, periapical granuloma, suppurative periapical periodontitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 17.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 15 |
| PHASE4 | 1 |
| PHASE2/PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06860191 | PHASE4 | NOT_YET_RECRUITING | Effect of Different Sealers and Activation Methods on Pain |
| NCT04336709 | PHASE2/PHASE3 | COMPLETED | Comparison of Anti-microbial Efficacy of Calcipex and Metapex in Endodontic Treatment of Chronic Apical Periodontitis |
| NCT07059481 | Not specified | RECRUITING | Effect of Different Root Canal Sealers on Oxidative Stress Markers |
| NCT07069881 | Not specified | RECRUITING | Sonic vs Passive Ultrasonic Irrigation for Chronic Apical Periodontitis |
| NCT07192289 | Not specified | NOT_YET_RECRUITING | Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth |
| NCT07353008 | Not specified | ACTIVE_NOT_RECRUITING | Effect of Different Chelation Protocols on the Healing of Periapical Lesions in Teeth With Chronic Apical Periodontitis |
| NCT07388901 | Not specified | RECRUITING | In Vivo Study on the Material Properties of iRoot SP and nRoot SP Root Canal Sealers |
| NCT07529964 | Not specified | NOT_YET_RECRUITING | MMP-2/3 and Periapical Healing Outcomes |
| NCT07542223 | Not specified | ACTIVE_NOT_RECRUITING | The Aim of This Study is to Evaluate the Relationship Between Genetic Polymorphisms and Periapical Lesion Healing in Individuals With Chronic Apical Periodontitis at Clinical and Radiological Levels. |
| NCT07607314 | Not specified | NOT_YET_RECRUITING | Rotary Versus Manual Degranulation in Alveolar Ridge Preservation |
| NCT04389346 | Not specified | UNKNOWN | A Cone Beam Computed Tomographic Evaluation of Healing of Apicomarginal Defects Using Autologous Platelet Aggregates |
| NCT05744661 | Not specified | COMPLETED | Mechanical Vs Chemomechanical Method For Calcium Hydroxide Removal |
| NCT06834711 | Not specified | COMPLETED | Chlorhexidine Versus N-Asetil Sistein Irrigation in Mandibular Molar Teeth with Chronic Apical Periodontitis |
| NCT07033247 | Not specified | COMPLETED | The Effect of Different Sodium Hypochlorite Concentrations and Activation Techniques on Postoperative Pain |
| NCT07057336 | Not specified | COMPLETED | Evaluation of Post-Operative Pain Following the Use of Nano-Calcium Hydroxide |
| NCT07340944 | Not specified | COMPLETED | Comparison of the Effects of N-acetylcysteine, Calcium Hydroxide, and Double Antibiotic Paste |
| NCT07480226 | Not specified | COMPLETED | Single Versus Multiple Visits Regenerative Endodontics in Mature Teeth |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ACETYLCYSTEINE | 4 | 1 |
| CALCIUM HYDROXIDE | 3 | 1 |
Related Atlas pages
- Drugs: Acetylcysteine, Calcium Hydroxide