Chronic asthma
diseaseOn this page
Also known as adult-onset severe asthmapersistent mild asthmapersistent moderate asthmapersistent severe asthma
Summary
Chronic asthma (MONDO:0850282) is a disease (an umbrella term covering 5 Mondo subtypes) and 36 clinical trials. Top therapeutic interventions include prasugrel and doxofylline. A subtype of asthma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Umbrella term: 5 Mondo subtypes
- Clinical trials: 36
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | chronic asthma |
| Mondo ID | MONDO:0850282 |
| DOID | DOID:0080809 |
| UMLS | C0877430 |
| MedGen | 1843404 |
| Is cancer (heuristic) | no |
Also known as: adult-onset severe asthma · persistent mild asthma · persistent moderate asthma · persistent severe asthma
Disease family
This is a subtype of asthma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › respiratory system disorder › lower respiratory tract disorder › bronchial disorder › asthma › chronic asthma
Related subtypes (7): cough variant asthma, intrinsic asthma, status asthmaticus, allergic asthma, childhood onset asthma, occupational asthma, acute asthma
Subtypes (5): extrinsic asthma, intermittent asthma, T2-high asthma, T2-low asthma, nocturnal asthma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 36.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 30 |
| PHASE2 | 3 |
| PHASE4 | 1 |
| PHASE3 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01305369 | PHASE4 | COMPLETED | The Effect of Prasugrel on Bronchial Hyperreactivity and on Markers of Inflammation in Patients With Chronic Asthma |
| NCT03879590 | PHASE3 | UNKNOWN | Efficacy Of Doxophylline As A Sparing Treatment For Inhaled Corticosteroids In Mexican Children With Asthma |
| NCT06273072 | PHASE2 | RECRUITING | Metformin IN Asthma for Overweight and Obese Individuals (MINA) |
| NCT02227394 | PHASE2 | COMPLETED | Study to Compare the Effects of Z7200 And Symbicort® Turbohaler on Respiratory Imaging Parameters in Asthmatic Patients |
| NCT03736629 | PHASE2 | TERMINATED | Azithromycin Treatment for the Airway Microbiome in Asthma |
| NCT00739297 | PHASE1 | COMPLETED | The Safety and Effectiveness of MK0476 (Montelukast) in Patients With Chronic Asthma (0476-388) |
| NCT04395937 | Not specified | RECRUITING | SAMBA Trial: Towards a Paradigm Shift in Severe Asthma Management: Deep Analysis of the Effect of suBmaximal Aerobic Training |
| NCT05572177 | Not specified | RECRUITING | Feasibility of a Smartphone Application for Asthma Self-management |
| NCT06163807 | Not specified | RECRUITING | Follow-up of Spanish Prospective Asthma and Nasal Polyposis Registry |
| NCT06304207 | Not specified | RECRUITING | Telehealth and Onsite Maintenance Exercise in Chronic Lung Disease |
| NCT06377345 | Not specified | RECRUITING | Remote Patient Monitoring Solution for Chronic Respiratory Disease Management |
| NCT06457009 | Not specified | ACTIVE_NOT_RECRUITING | Impact of Multi-Component Intervention on Suspected Asthma Population |
| NCT06596512 | Not specified | NOT_YET_RECRUITING | Improving the Quality of Care for Asthma Patients at Risk of Exacerbations |
| NCT07512622 | Not specified | NOT_YET_RECRUITING | Asthma Ctrl SMART Trial |
| NCT07611955 | Not specified | NOT_YET_RECRUITING | A Study of Acupuncture for Treating Asthma |
| NCT02283008 | Not specified | UNKNOWN | Inhaler Technique Training |
| NCT02386722 | Not specified | COMPLETED | Intervention to Improve Inhalative Adherence |
| NCT03036267 | Not specified | COMPLETED | Feasibility of the BREATHE Asthma Intervention Trial |
| NCT03498742 | Not specified | COMPLETED | Asthmatic Subjects Could Live Without Short Acting beta2 Agonists |
| NCT03642418 | Not specified | COMPLETED | User-Friendly Spirometer and Mobile App for Self-Management and Home Monitoring of Asthma Patients |
| NCT03788057 | Not specified | COMPLETED | Inflammatory Indices in Predicting the Failure of Inhaled Corticosteroids Reduction in Young Participants With Asthma |
| NCT04438408 | Not specified | UNKNOWN | National Survey on Care Pathway and Quality of Life in Patients With Severe Asthma According to Their Phenotype. |
| NCT04456270 | Not specified | COMPLETED | Asthma Control in a Dutch Primary Care Population |
| NCT04593394 | Not specified | COMPLETED | Inducible Laryngeal Obstruction in Severe Asthma in Severe Asthma |
| NCT04613245 | Not specified | COMPLETED | Health-Related Quality of Life of Patients With Asthma During the Pandemic of COVID-19 |
| NCT04693975 | Not specified | UNKNOWN | Social Distancing During the COVID-19 Pandemic and People Living With Chronic Respiratory Diseases |
| NCT04799678 | Not specified | UNKNOWN | Pilot Voice Sample Collection From People With Asthma |
| NCT05270278 | Not specified | COMPLETED | Characteristics of Type 2- High Inflammatory Endotype of Asthma Using New Biomarkers From Peripheral Blood and Exhaled Air and Its Effect on the Outcome of Therapy |
| NCT05304494 | Not specified | WITHDRAWN | Sentinel - Triaging Acute Breathlessness Using Multi-Modal Biomarkers |
| NCT05432440 | Not specified | UNKNOWN | Evaluation of Pharmacist-guided Digital-based Asthma Education for Indonesian Children With Asthma |
| NCT05609760 | Not specified | TERMINATED | Pictograms to Facilitate Comprehension of Medical Indications |
| NCT05841901 | Not specified | UNKNOWN | Huang-long Zhi-xiao Granule Improves the Control Rate of Chronic Persistent of Asthma |
| NCT06364527 | Not specified | COMPLETED | Use of Aptar Digital Health’s Respiratory Disease Management Platform for Asthma |
| NCT07394127 | Not specified | COMPLETED | Effects of Inspiratory Muscle Training Added to a Swimming Program in Children With Asthma |
| NCT07477080 | Not specified | COMPLETED | Breathing Exercises Effect on Lung Functions and Chest Expansion in Asthmatics |
| NCT07508267 | Not specified | COMPLETED | Thoracic Spine Rotation Stretching and Scapular Retraction in Asthma Patients |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| PRASUGREL | 4 | 1 |
| DOXOFYLLINE | 3 | 1 |
Related Atlas pages
- Drugs: Prasugrel, Doxofylline